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Ift46 intraflagellar transport 46 [ Rattus norvegicus (Norway rat) ]

Gene ID: 300675, updated on 27-Nov-2024

Summary

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Official Symbol
Ift46provided by RGD
Official Full Name
intraflagellar transport 46provided by RGD
Primary source
RGD:1307682
See related
EnsemblRapid:ENSRNOG00000013919 AllianceGenome:RGD:1307682
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1307682
Summary
Predicted to be involved in cilium assembly and intraciliary transport. Predicted to act upstream of or within smoothened signaling pathway. Predicted to be located in centrosome; cilium; and cytoplasm. Predicted to be part of intraciliary transport particle B. Predicted to be active in microtubule organizing center and motile cilium. Orthologous to human IFT46 (intraflagellar transport 46). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Testes (RPKM 195.5), Kidney (RPKM 118.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ift46 in Genome Data Viewer
Location:
8q22
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (53975085..54000837)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (45081593..45104052)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (49075978..49097689)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120094134 Neighboring gene pleckstrin homology-like domain, family B, member 1 Neighboring gene uncharacterized LOC134480161 Neighboring gene archain 1 Neighboring gene transmembrane protein 25 Neighboring gene tetratricopeptide repeat domain 36

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Knockdown of the intraflagellar transport protein IFT46 stimulates selective gene expression in mouse chondrocytes and affects early development in zebrafish. Gouttenoire J, et al. J Biol Chem, 2007 Oct 19. PMID 17720815
  2. Functional analysis of an individual IFT protein: IFT46 is required for transport of outer dynein arms into flagella. Hou Y, et al. J Cell Biol, 2007 Feb 26. PMID 17312020, Free PMC Article
  3. Functional characterization of putative cilia genes by high-content analysis. Lai CK, et al. Mol Biol Cell, 2011 Apr. PMID 21289087, Free PMC Article
  4. The intraflagellar transport protein IFT27 promotes BBSome exit from cilia through the GTPase ARL6/BBS3. Liew GM, et al. Dev Cell, 2014 Nov 10. PMID 25443296, Free PMC Article
  5. TTC26/DYF13 is an intraflagellar transport protein required for transport of motility-related proteins into flagella. Ishikawa H, et al. Elife, 2014 Jan 1. PMID 24596149, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Characterization of a similar gene in mouse and zebrafish.
    Title: Knockdown of the intraflagellar transport protein IFT46 stimulates selective gene expression in mouse chondrocytes and affects early development in zebrafish.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in intraciliary transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intraciliary transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within smoothened signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cilium IEA
Inferred from Electronic Annotation
more info
  
located_in cilium ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
part_of intraciliary transport particle B IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of intraciliary transport particle B IEA
Inferred from Electronic Annotation
more info
  
part_of intraciliary transport particle B ISO
Inferred from Sequence Orthology
more info
  
part_of intraciliary transport particle B ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in microtubule organizing center IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in motile cilium IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in motile cilium ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
intraflagellar transport protein 46 homolog
Names
intraflagellar transport 46 homolog
intraflagellar transport protein IFT46

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024760.1 → NP_001019931.1  intraflagellar transport protein 46 homolog

    See identical proteins and their annotated locations for NP_001019931.1

    Status: PROVISIONAL

    Source sequence(s)
    BC097954
    UniProtKB/Swiss-Prot
    Q4V7E9, Q6AXQ9
    UniProtKB/TrEMBL
    A0A8I6A7T4, A6J410
    Related
    ENSRNOP00000109736.1, ENSRNOT00000154047.1
    Conserved Domains (1) summary
    pfam12317
    Location:62 → 264
    IFT46_B_C; Intraflagellar transport complex B protein 46 C terminal

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    53975085..54000837
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039081057.2 → XP_038936985.1  intraflagellar transport protein 46 homolog isoform X2

    UniProtKB/Swiss-Prot
    Q4V7E9, Q6AXQ9
    UniProtKB/TrEMBL
    A0A8I6A7T4, A6J410
    Conserved Domains (1) summary
    pfam12317
    Location:62 → 264
    IFT46_B_C; Intraflagellar transport complex B protein 46 C terminal

  2. XM_006242930.5 → XP_006242992.1  intraflagellar transport protein 46 homolog isoform X2

    See identical proteins and their annotated locations for XP_006242992.1

    UniProtKB/Swiss-Prot
    Q4V7E9, Q6AXQ9
    UniProtKB/TrEMBL
    A0A8I6A7T4, A6J410
    Conserved Domains (1) summary
    pfam12317
    Location:62 → 264
    IFT46_B_C; Intraflagellar transport complex B protein 46 C terminal

  3. XM_017595553.3 → XP_017451042.3  intraflagellar transport protein 46 homolog isoform X1

    UniProtKB/TrEMBL
    A0A8L2R0P7
    Related
    ENSRNOP00000069445.2, ENSRNOT00000087922.3
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6AXQ9.2 GenPept UniProtKB/Swiss-Prot:Q6AXQ9

Gene LinkOut

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