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Gramd1b GRAM domain containing 1B [ Rattus norvegicus (Norway rat) ]

Gene ID: 300644, updated on 27-Nov-2024

Summary

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Symbol
Gramd1bprovided by RGD
Full Name
GRAM domain containing 1Bprovided by RGD
Primary source
RGD:1305443
See related
EnsemblRapid:ENSRNOG00000053577 AllianceGenome:RGD:1305443
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1305443
Summary
Predicted to enable cholesterol binding activity; cholesterol transfer activity; and phospholipid binding activity. Predicted to be involved in cellular response to cholesterol; cholesterol homeostasis; and intracellular sterol transport. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum membrane; endoplasmic reticulum-plasma membrane contact site; and plasma membrane. Orthologous to human GRAMD1B (GRAM domain containing 1B). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 464.1), Kidney (RPKM 85.4) and 4 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Gramd1b in Genome Data Viewer
Location:
8q22
Exon count:
37
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (49551642..49790965, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (40654492..40893869, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (44160634..44399110, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120094120 Neighboring gene zinc finger protein 202 Neighboring gene sodium voltage-gated channel beta subunit 3 Neighboring gene uncharacterized LOC134480034 Neighboring gene uncharacterized LOC134480035 Neighboring gene uncharacterized LOC134480138

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Aster Proteins Facilitate Nonvesicular Plasma Membrane to ER Cholesterol Transport in Mammalian Cells. Sandhu J, et al. Cell, 2018 Oct 4. PMID 30220461, Free PMC Article
  2. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cholesterol binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cholesterol binding ISO
Inferred from Sequence Orthology
more info
  
enables cholesterol transfer activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cholesterol transfer activity ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidic acid binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylserine binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in cellular response to cholesterol ISO
Inferred from Sequence Orthology
more info
  
involved_in cholesterol homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular sterol transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum-plasma membrane contact site IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum-plasma membrane contact site ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein Aster-B
Names
GRAM domain-containing protein 1B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191616.1 → NP_001178545.1  protein Aster-B

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A0A8I5ZLB1
    Related
    ENSRNOP00000110666.1, ENSRNOT00000172877.1
    Conserved Domains (2) summary
    cd13220
    Location:251 → 344
    PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
    pfam16016
    Location:519 → 663
    DUF4782; Domain of unknown function (DUF4782)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    49551642..49790965 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063265091.1 → XP_063121161.1  protein Aster-B isoform X9

    UniProtKB/TrEMBL
    A0A8I6A3S5
    Related
    ENSRNOP00000086431.1, ENSRNOT00000098747.2

  2. XM_063265090.1 → XP_063121160.1  protein Aster-B isoform X8

    Related
    ENSRNOP00000084513.2, ENSRNOT00000119190.2

  3. XM_063265084.1 → XP_063121154.1  protein Aster-B isoform X1

  4. XM_063265086.1 → XP_063121156.1  protein Aster-B isoform X4

  5. XM_039081030.2 → XP_038936958.1  protein Aster-B isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZLB1, A0A8I6A887
    Related
    ENSRNOP00000088511.1, ENSRNOT00000099621.2
    Conserved Domains (2) summary
    cd13220
    Location:250 → 343
    PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
    pfam16016
    Location:518 → 666
    DUF4782; Domain of unknown function (DUF4782)

  6. XM_063265085.1 → XP_063121155.1  protein Aster-B isoform X2

  7. XM_063265089.1 → XP_063121159.1  protein Aster-B isoform X7

  8. XM_063265099.1 → XP_063121169.1  protein Aster-B isoform X6

  9. XM_063265088.1 → XP_063121158.1  protein Aster-B isoform X6

    Related
    ENSRNOP00000094998.2, ENSRNOT00000097795.2

  10. XM_063265098.1 → XP_063121168.1  protein Aster-B isoform X6

  11. XM_063265092.1 → XP_063121162.1  protein Aster-B isoform X10

    UniProtKB/TrEMBL
    A0A8I6AAR1
    Related
    ENSRNOP00000093680.2, ENSRNOT00000107338.2

  12. XM_063265093.1 → XP_063121163.1  protein Aster-B isoform X11

  13. XM_063265094.1 → XP_063121164.1  protein Aster-B isoform X6

  14. XM_063265095.1 → XP_063121165.1  protein Aster-B isoform X6

  15. XM_063265097.1 → XP_063121167.1  protein Aster-B isoform X6

  16. XM_063265096.1 → XP_063121166.1  protein Aster-B isoform X6

  17. XM_039081042.2 → XP_038936970.1  protein Aster-B isoform X12

    UniProtKB/TrEMBL
    A0A8I5ZZR8, A0A8I6GLE8
    Conserved Domains (2) summary
    cd13220
    Location:71 → 164
    PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
    pfam16016
    Location:339 → 487
    DUF4782; Domain of unknown function (DUF4782)

  18. XM_063265087.1 → XP_063121157.1  protein Aster-B isoform X5

  19. XM_063265100.1 → XP_063121170.1  protein Aster-B isoform X13

  20. XM_063265101.1 → XP_063121171.1  protein Aster-B isoform X14

RNA

  1. XR_010053942.1 RNA Sequence

  2. XR_010053943.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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