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Ecsit ECSIT signaling integrator [ Rattus norvegicus (Norway rat) ]

Gene ID: 300447, updated on 4-Jan-2025

Summary

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Official Symbol
Ecsitprovided by RGD
Official Full Name
ECSIT signaling integratorprovided by RGD
Primary source
RGD:1359488
See related
EnsemblRapid:ENSRNOG00000014128 AllianceGenome:RGD:1359488
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable DNA-binding transcription factor activity; chromatin binding activity; and molecular adaptor activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; innate immune response; and regulation of protein complex stability. Predicted to act upstream of or within BMP signaling pathway; mesoderm formation; and regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of transcription regulator complex. Predicted to be active in mitochondrion. Orthologous to human ECSIT (ECSIT signaling integrator). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Heart (RPKM 551.4), Muscle (RPKM 452.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ecsit in Genome Data Viewer
Location:
8q13
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (28881594..28894443, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (20605583..20618453, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (23085598..23099064, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene ELAV like RNA binding protein 3 Neighboring gene zinc finger protein 653 Neighboring gene uncharacterized LOC120094091 Neighboring gene calponin 1 Neighboring gene elongation factor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Cytosolic signaling protein Ecsit also localizes to mitochondria where it interacts with chaperone NDUFAF1 and functions in complex I assembly. Vogel RO, et al. Genes Dev, 2007 Mar 1. PMID 17344420, Free PMC Article
  2. TRIM59 interacts with ECSIT and negatively regulates NF-κB and IRF-3/7-mediated signal pathways. Kondo T, et al. Biochem Biophys Res Commun, 2012 Jun 8. PMID 22588174
  3. Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis. Xiao C, et al. Genes Dev, 2003 Dec 1. PMID 14633973, Free PMC Article
  4. ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway. Kopp E, et al. Genes Dev, 1999 Aug 15. PMID 10465784, Free PMC Article
  5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Clone Names

  • MGC94704

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in cell surface receptor protein serine/threonine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell surface receptor protein serine/threonine kinase signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mesoderm formation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of oxidoreductase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of oxidoreductase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of protein complex stability ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein complex stability ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in toll-like receptor 4 signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of transcription regulator complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial
Names
ECSIT homolog
ECSIT signalling integrator

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001006986.1 → NP_001006987.1  evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial precursor

    See identical proteins and their annotated locations for NP_001006987.1

    Status: PROVISIONAL

    Source sequence(s)
    BC083762
    UniProtKB/Swiss-Prot
    Q5XIC2
    UniProtKB/TrEMBL
    A0A8I5ZQV7, A6JNY0
    Related
    ENSRNOP00000019115.3, ENSRNOT00000019115.7
    Conserved Domains (3) summary
    sd00004
    Location:125 → 170
    PPR; PPR repeat [structural motif]
    pfam06239
    Location:49 → 265
    ECSIT; Evolutionarily conserved signalling intermediate in Toll pathway
    pfam14784
    Location:268 → 392
    ECSIT_C; C-terminal domain of the ECSIT protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    28881594..28894443 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006242636.5 → XP_006242698.1  evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006242698.1

    UniProtKB/TrEMBL
    A0A8I5ZQV7
    Conserved Domains (3) summary
    sd00004
    Location:125 → 170
    PPR; PPR repeat [structural motif]
    pfam06239
    Location:49 → 271
    ECSIT; Evolutionarily conserved signalling intermediate in Toll pathway
    pfam14784
    Location:274 → 398
    ECSIT_C; C-terminal domain of the ECSIT protein

  2. XM_006242637.5 → XP_006242699.1  evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006242699.1

    UniProtKB/TrEMBL
    A0A8I5ZQV7
    Conserved Domains (3) summary
    sd00004
    Location:125 → 170
    PPR; PPR repeat [structural motif]
    pfam06239
    Location:49 → 271
    ECSIT; Evolutionarily conserved signalling intermediate in Toll pathway
    pfam14784
    Location:274 → 398
    ECSIT_C; C-terminal domain of the ECSIT protein

  3. XM_006242638.5 → XP_006242700.1  evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial isoform X2

    See identical proteins and their annotated locations for XP_006242700.1

    UniProtKB/Swiss-Prot
    Q5XIC2
    UniProtKB/TrEMBL
    A0A8I5ZQV7, A6JNY0
    Conserved Domains (3) summary
    sd00004
    Location:125 → 170
    PPR; PPR repeat [structural motif]
    pfam06239
    Location:49 → 265
    ECSIT; Evolutionarily conserved signalling intermediate in Toll pathway
    pfam14784
    Location:268 → 392
    ECSIT_C; C-terminal domain of the ECSIT protein

  4. XM_039081013.2 → XP_038936941.1  evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial isoform X2

    UniProtKB/Swiss-Prot
    Q5XIC2
    UniProtKB/TrEMBL
    A0A8I5ZQV7, A6JNY0
    Conserved Domains (3) summary
    sd00004
    Location:125 → 170
    PPR; PPR repeat [structural motif]
    pfam06239
    Location:49 → 265
    ECSIT; Evolutionarily conserved signalling intermediate in Toll pathway
    pfam14784
    Location:268 → 392
    ECSIT_C; C-terminal domain of the ECSIT protein

  5. XM_039081012.2 → XP_038936940.1  evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZQV7
    Conserved Domains (3) summary
    sd00004
    Location:125 → 170
    PPR; PPR repeat [structural motif]
    pfam06239
    Location:49 → 271
    ECSIT; Evolutionarily conserved signalling intermediate in Toll pathway
    pfam14784
    Location:274 → 398
    ECSIT_C; C-terminal domain of the ECSIT protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5XIC2.1 GenPept UniProtKB/Swiss-Prot:Q5XIC2

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