U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Prkcsh PRKCSH beta subunit of glucosidase II [ Rattus norvegicus (Norway rat) ]

Gene ID: 300445, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
Prkcshprovided by RGD
Official Full Name
PRKCSH beta subunit of glucosidase IIprovided by RGD
Primary source
RGD:1309628
See related
EnsemblRapid:ENSRNOG00000013360 AllianceGenome:RGD:1309628
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable several functions, including calcium ion binding activity; protein kinase C binding activity; and transmembrane transporter binding activity. Predicted to be involved in N-glycan processing and liver development. Predicted to act upstream of or within in utero embryonic development; negative regulation of neuron projection development; and nitrogen cycle metabolic process. Predicted to be located in endoplasmic reticulum. Predicted to be part of glucosidase II complex. Human ortholog(s) of this gene implicated in liver disease and polycystic liver disease 1. Orthologous to human PRKCSH (PRKCSH beta subunit of glucosidase II). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Kidney (RPKM 427.8), Adrenal (RPKM 359.1) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Prkcsh in Genome Data Viewer
Location:
8q13
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (28810836..28822503)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (20534787..20546493)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (23014802..23026507)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene ral guanine nucleotide dissociation stimulator like 3 Neighboring gene uncharacterized LOC134480147 Neighboring gene outer dynein arm docking complex subunit 3 Neighboring gene ELAV like RNA binding protein 3 Neighboring gene zinc finger protein 653 Neighboring gene uncharacterized LOC120094091

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Hepatocystin contributes to interferon-mediated antiviral response to hepatitis B virus by regulating hepatocyte nuclear factor 4α. Shin GC, et al. Biochim Biophys Acta, 2014 Sep. PMID 24769044
  2. Abnormal hepatocystin caused by truncating PRKCSH mutations leads to autosomal dominant polycystic liver disease. Drenth JP, et al. Hepatology, 2004 Apr. PMID 15057895
  3. Domain-specific gene activation by parathyroid hormone in osteoblastic ROS17/2.8 cells. Hollnagel A, et al. J Biol Chem, 1996 Sep 6. PMID 8702988
  4. A novel RNA binding protein that interacts with NMDA R1 mRNA: regulation by ethanol. Anji A, et al. Eur J Neurosci, 2006 May. PMID 16706842
  5. Mutations in PRKCSH cause isolated autosomal dominant polycystic liver disease. Li A, et al. Am J Hum Genet, 2003 Mar. PMID 12529853, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphoprotein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase C binding ISO
Inferred from Sequence Orthology
more info
  
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transmembrane transporter binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in N-glycan processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in N-glycan processing ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within in utero embryonic development ISO
Inferred from Sequence Orthology
more info
  
involved_in liver development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within liver development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
  
involved_in nitrogen cycle metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within nitrogen cycle metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
part_of glucosidase II complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of glucosidase II complex ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

Go to the top of the page Help
Preferred Names
glucosidase 2 subunit beta
Names
protein kinase C substrate 80K-H
NP_001100276.1
XP_006242695.1
XP_006242696.1
XP_063121136.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106806.2 → NP_001100276.1  glucosidase 2 subunit beta precursor

    See identical proteins and their annotated locations for NP_001100276.1

    Status: PROVISIONAL

    Source sequence(s)
    BC161987
    UniProtKB/TrEMBL
    A0A8I6ADW9, B1WC34, F7EM53
    Related
    ENSRNOP00000101711.1, ENSRNOT00000166669.1
    Conserved Domains (3) summary
    smart00192
    Location:36 → 63
    LDLa; Low-density lipoprotein receptor domain class A
    cl06793
    Location:377 → 505
    PRKCSH; Glucosidase II beta subunit-like protein
    cl21478
    Location:113 → 255
    ATP-synt_B; ATP synthase B/B' CF(0)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    28810836..28822503
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006242634.2 → XP_006242696.1  glucosidase 2 subunit beta isoform X2

    UniProtKB/TrEMBL
    A6JNX3
    Related
    ENSRNOP00000018009.6, ENSRNOT00000018009.8
    Conserved Domains (3) summary
    pfam12999
    Location:20 → 162
    PRKCSH-like; Glucosidase II beta subunit-like
    cl06793
    Location:370 → 498
    PRKCSH; Glucosidase II beta subunit-like protein
    cl21478
    Location:113 → 255
    ATP-synt_B; ATP synthase B/B' CF(0)

  2. XM_063265066.1 → XP_063121136.1  glucosidase 2 subunit beta isoform X1

    UniProtKB/TrEMBL
    A0A8I6ADW9, B1WC34, F7EM53
    Related
    ENSRNOP00000086800.2, ENSRNOT00000103948.2

  3. XM_006242633.5 → XP_006242695.1  glucosidase 2 subunit beta isoform X1

    See identical proteins and their annotated locations for XP_006242695.1

    UniProtKB/TrEMBL
    A0A8I6ADW9, B1WC34, F7EM53
    Conserved Domains (3) summary
    smart00192
    Location:36 → 63
    LDLa; Low-density lipoprotein receptor domain class A
    cl06793
    Location:377 → 505
    PRKCSH; Glucosidase II beta subunit-like protein
    cl21478
    Location:113 → 255
    ATP-synt_B; ATP synthase B/B' CF(0)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous