U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Atg101 autophagy related 101 [ Rattus norvegicus (Norway rat) ]

Gene ID: 300240, updated on 27-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Atg101provided by RGD
Official Full Name
autophagy related 101provided by RGD
Primary source
RGD:1359310
See related
EnsemblRapid:ENSRNOG00000007756 AllianceGenome:RGD:1359310
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1359310
Summary
Predicted to enable identical protein binding activity and protein kinase binding activity. Predicted to be involved in several processes, including autophagosome assembly; positive regulation of autophagy; and regulation of protein lipidation. Predicted to be part of Atg1/ULK1 kinase complex. Predicted to be active in phagophore assembly site. Orthologous to human ATG101 (autophagy related 101). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Muscle (RPKM 167.3), Adrenal (RPKM 131.0) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Atg101 in Genome Data Viewer
Location:
7q36
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (134277223..134286387)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (132398477..132407643)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (142929381..142938559)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479787 Neighboring gene uncharacterized LOC134479786 Neighboring gene nuclear receptor subfamily 4, group A, member 1 Neighboring gene small integral membrane protein 41 Neighboring gene keratin 80

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Comprehensive Analysis of the Potential Immune-Related Biomarker ATG101 that Regulates Apoptosis of Cholangiocarcinoma Cells After Photodynamic Therapy. Zhang ZJ, et al. Front Pharmacol, 2022. PMID 35592424, Free PMC Article
  2. Development and validation of prognostic model based on the analysis of autophagy-related genes in colon cancer. Wang Y, et al. Aging (Albany NY), 2021 Jul 27. PMID 34315829, Free PMC Article
  3. Atg101, a novel mammalian autophagy protein interacting with Atg13. Hosokawa N, et al. Autophagy, 2009 Oct. PMID 19597335
  4. Network organization of the human autophagy system. Behrends C, et al. Nature, 2010 Jul 1. PMID 20562859, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC94201

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in autophagosome assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in autophagosome assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in autophagy IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of autophagy IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of autophagy ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein lipidation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of protein lipidation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of Atg1/ULK1 kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Atg1/ULK1 kinase complex IEA
Inferred from Electronic Annotation
more info
  
part_of Atg1/ULK1 kinase complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in phagophore assembly site IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in phagophore assembly site IEA
Inferred from Electronic Annotation
more info
  
located_in phagophore assembly site ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
autophagy-related protein 101

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007659.2 → NP_001007660.2  autophagy-related protein 101 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC079170, JAXUCZ010000007
    UniProtKB/TrEMBL
    A0A8L2Q495, A0A8L2R4A7
    Related
    ENSRNOP00000010195.3, ENSRNOT00000010194.5
    Conserved Domains (1) summary
    pfam07855
    Location:54 → 217
    DUF1649; Protein of unknown function (DUF1649)

  2. NM_001271114.1 → NP_001258043.1  autophagy-related protein 101 isoform 2

    See identical proteins and their annotated locations for NP_001258043.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks a portion of the 5' coding region compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (2) with a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    BU670996, JAXUCZ010000007
    UniProtKB/Swiss-Prot
    Q6AY69
    UniProtKB/TrEMBL
    A0A8L2R4A7, A6KCP1
    Conserved Domains (1) summary
    pfam07855
    Location:9 → 172
    ATG101; Autophagy-related protein 101

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    134277223..134286387
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006242324.5 → XP_006242386.1  autophagy-related protein 101 isoform X1

    See identical proteins and their annotated locations for XP_006242386.1

    UniProtKB/Swiss-Prot
    Q6AY69
    UniProtKB/TrEMBL
    A0A8L2R4A7, A6KCP1
    Conserved Domains (1) summary
    pfam07855
    Location:9 → 172
    ATG101; Autophagy-related protein 101
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6AY69.1 GenPept UniProtKB/Swiss-Prot:Q6AY69

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous