Dazap2 DAZ associated protein 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dazap2provided by RGD
Official Full Name: DAZ associated protein 2provided by RGD
Primary source: RGD:1307407
See related: EnsemblRapid:ENSRNOG00000004628 AllianceGenome:RGD:1307407
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including WW domain binding activity; enzyme binding activity; and p53 binding activity. Predicted to be involved in protein destabilization and stress granule assembly. Predicted to be located in cytoplasmic stress granule and nuclear speck. Predicted to be part of protein-containing complex. Orthologous to human DAZAP2 (DAZ associated protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 1223.0), Heart (RPKM 1012.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q36

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (133593503..133599044)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (131714749..131720266)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (142238780..142244301)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

RH127546 (e-PCR)
- UniSTS:210856

RH134787 (e-PCR)
- UniSTS:218065

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables WW domain binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables mitogen-activated protein kinase kinase kinase binding	ISO Inferred from Sequence Orthology more info
enables p53 binding	ISO Inferred from Sequence Orthology more info
enables p53 binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein serine/threonine kinase activator activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase binding	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase binding	ISS Inferred from Sequence or Structural Similarity more info
enables receptor tyrosine kinase binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in protein destabilization	ISO Inferred from Sequence Orthology more info
involved_in protein destabilization	ISS Inferred from Sequence or Structural Similarity more info
involved_in stress granule assembly	ISO Inferred from Sequence Orthology more info
involved_in stress granule assembly	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasmic stress granule	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic stress granule	ISS Inferred from Sequence or Structural Similarity more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nuclear body	ISS Inferred from Sequence or Structural Similarity more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: DAZ-associated protein 2

Names: deleted in azoospermia-associated protein 2; proline-rich transcript in brain protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001395672.1 → NP_001382601.1 DAZ-associated protein 2 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

JAXUCZ010000007

UniProtKB/Swiss-Prot

A0A0H2UHD1, P60486

Conserved Domains (1) summary

pfam11029
Location:35 → 168

DAZAP2; DAZ associated protein 2 (DAZAP2)
NM_001395673.1 → NP_001382602.1 DAZ-associated protein 2 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

Conserved Domains (1) summary

pfam11029
Location:1 → 108

DAZAP2; DAZ associated protein 2 (DAZAP2)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

133593503..133599044

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039078934.2 → XP_038934862.1 DAZ-associated protein 2 isoform X1

UniProtKB/Swiss-Prot

A0A0H2UHD1, P60486

Related

ENSRNOP00000006239.6, ENSRNOT00000006239.9

Conserved Domains (1) summary

pfam11029
Location:35 → 168

DAZAP2; DAZ associated protein 2 (DAZAP2)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001013107.1: Suppressed sequence

Description

NM_001013107.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.