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Fmnl3 formin-like 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 300225, updated on 27-Nov-2024

Summary

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Official Symbol
Fmnl3provided by RGD
Official Full Name
formin-like 3provided by RGD
Primary source
RGD:1583854
See related
EnsemblRapid:ENSRNOG00000056297 AllianceGenome:RGD:1583854
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable GTPase activating protein binding activity and actin filament binding activity. Predicted to be involved in several processes, including cortical actin cytoskeleton organization; filopodium assembly; and regulation of cell shape. Predicted to be located in Golgi apparatus and plasma membrane. Predicted to be active in cytosol. Orthologous to human FMNL3 (formin like 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 187.5), Lung (RPKM 179.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Fmnl3 in Genome Data Viewer
Location:
7q36
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (132333130..132384483, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (130454270..130505626, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (140981801..141033318, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA70 Neighboring gene pre-mRNA processing factor 40 homolog B Neighboring gene family with sequence similarity 186, member B Neighboring gene transmembrane BAX inhibitor motif containing 6 Neighboring gene NCK-associated protein 5-like Neighboring gene uncharacterized LOC134479570

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Bi-modal regulation of a formin by srGAP2. Mason FM, et al. J Biol Chem, 2011 Feb 25. PMID 21148482, Free PMC Article
  2. Identification and characterization of a set of conserved and new regulators of cytoskeletal organization, cell morphology and migration. Bai SW, et al. BMC Biol, 2011 Aug 11. PMID 21834987, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTPase activating protein binding ISO
Inferred from Sequence Orthology
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in cortical actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in filopodium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell shape IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cell shape ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
formin-like protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001399766.1 → NP_001386695.1  formin-like protein 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    A0A8I6A3S6
    Related
    ENSRNOP00000085382.1, ENSRNOT00000101420.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    132333130..132384483 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063263386.1 → XP_063119456.1  formin-like protein 3 isoform X2

    UniProtKB/TrEMBL
    A0A8I6ART4
    Related
    ENSRNOP00000097005.1, ENSRNOT00000106042.2

  2. XM_039080568.2 → XP_038936496.1  formin-like protein 3 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZLE1
    Conserved Domains (3) summary
    pfam06367
    Location:237 → 434
    Drf_FH3; Diaphanous FH3 Domain
    pfam02181
    Location:518 → 883
    FH2; Formin Homology 2 Domain
    pfam06371
    Location:1 → 234
    Drf_GBD; Diaphanous GTPase-binding Domain

  3. XM_039080569.1 → XP_038936497.1  formin-like protein 3 isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZLE1
    Conserved Domains (3) summary
    pfam06367
    Location:135 → 332
    Drf_FH3; Diaphanous FH3 Domain
    pfam02181
    Location:416 → 781
    FH2; Formin Homology 2 Domain
    pfam06371
    Location:66 → 132
    Drf_GBD; Diaphanous GTPase-binding Domain

  4. XM_003752125.6 → XP_003752173.1  formin-like protein 3 isoform X2

    See identical proteins and their annotated locations for XP_003752173.1

    UniProtKB/TrEMBL
    A0A0G2JXC2, A0A8I6ART4
    Related
    ENSRNOP00000078509.2, ENSRNOT00000105112.2
    Conserved Domains (3) summary
    pfam02181
    Location:562 → 927
    FH2; Formin Homology 2 Domain
    pfam06367
    Location:281 → 478
    Drf_FH3; Diaphanous FH3 Domain
    pfam06371
    Location:26 → 278
    Drf_GBD; Diaphanous GTPase-binding Domain
Nucleotide Protein Strain
Heading Accession and Version

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