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Rhpn1 rhophilin, Rho GTPase binding protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 300030, updated on 27-Nov-2024

Summary

Official Symbol
Rhpn1provided by RGD
Official Full Name
rhophilin, Rho GTPase binding protein 1provided by RGD
Primary source
RGD:1305688
See related
EnsemblRapid:ENSRNOG00000007597 AllianceGenome:RGD:1305688
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in negative regulation of stress fiber assembly. Predicted to act upstream of or within several processes, including focal adhesion assembly; glomerular filtration; and renal albumin absorption. Predicted to be located in plasma membrane. Orthologous to human RHPN1 (rhophilin Rho GTPase binding protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 153.4), Testes (RPKM 27.6) and 3 other tissues See more
Orthologs
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Genomic context

See Rhpn1 in Genome Data Viewer
Location:
7q34
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (109272676..109283444)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (107391948..107402713)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (116738999..116749791)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene GLI family zinc finger 4 Neighboring gene DNA topoisomerase I mitochondrial Neighboring gene uncharacterized LOC134479926 Neighboring gene U6 spliceosomal RNA Neighboring gene MAF bZIP transcription factor A

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001305237.1NP_001292166.1  rhophilin-1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    A0A096MIZ0, A6HS15
    Conserved Domains (3) summary
    cd09248
    Location:116498
    BRO1_Rhophilin_1; Protein-interacting Bro1-like domain of RhoA-binding protein Rhophilin-1
    cd00992
    Location:519593
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl00087
    Location:28112
    HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    109272676..109283444
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006241901.5XP_006241963.1  rhophilin-1 isoform X2

    See identical proteins and their annotated locations for XP_006241963.1

    UniProtKB/TrEMBL
    A6HS15
    Conserved Domains (3) summary
    cd09248
    Location:116499
    BRO1_Rhophilin_1; Protein-interacting Bro1-like domain of RhoA-binding protein Rhophilin-1
    cd00992
    Location:520594
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl00087
    Location:28112
    HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
  2. XM_006241900.5XP_006241962.1  rhophilin-1 isoform X1

    See identical proteins and their annotated locations for XP_006241962.1

    UniProtKB/TrEMBL
    A6HS15
    Related
    ENSRNOP00000067928.3, ENSRNOT00000075837.4
    Conserved Domains (3) summary
    cd09248
    Location:116499
    BRO1_Rhophilin_1; Protein-interacting Bro1-like domain of RhoA-binding protein Rhophilin-1
    cd00992
    Location:520594
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl00087
    Location:28112
    HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
  3. XM_063263274.1XP_063119344.1  rhophilin-1 isoform X3

  4. XM_039078808.2XP_038934736.1  rhophilin-1 isoform X4

    Conserved Domains (2) summary
    cd00992
    Location:290364
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl14649
    Location:3269
    BRO1_Alix_like; Protein-interacting Bro1-like domain of mammalian Alix and related domains