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Utp23 UTP23, small subunit processome component [ Rattus norvegicus (Norway rat) ]

Gene ID: 299900, updated on 4-Jan-2025

Summary

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Official Symbol
Utp23provided by RGD
Official Full Name
UTP23, small subunit processome componentprovided by RGD
Primary source
RGD:1307179
See related
EnsemblRapid:ENSRNOG00000063314 AllianceGenome:RGD:1307179
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1307179
Summary
Predicted to enable mRNA 3'-UTR binding activity and mRNA 5'-UTR binding activity. Predicted to act upstream of or within endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Human ortholog(s) of this gene implicated in colorectal adenocarcinoma. Orthologous to human UTP23 (UTP23 small subunit processome component). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Kidney (RPKM 63.1), Thymus (RPKM 57.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Utp23 in Genome Data Viewer
Location:
7q31
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (85074713..85084766)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (83185187..83196652)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (91384329..91389605)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479728 Neighboring gene eukaryotic translation initiation factor 3, subunit H Neighboring gene ribosomal protein S16, pseudogene 9 Neighboring gene RAD21 cohesin complex component

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Recurrent Coding Sequence Variation Explains Only A Small Fraction of the Genetic Architecture of Colorectal Cancer. Timofeeva MN, et al. Sci Rep, 2015 Nov 10. PMID 26553438, Free PMC Article
  2. Two orthogonal cleavages separate subunit RNAs in mouse ribosome biogenesis. Wang M, et al. Nucleic Acids Res, 2014. PMID 25190460, Free PMC Article
  3. The roles of SSU processome components and surveillance factors in the initial processing of human ribosomal RNA. Sloan KE, et al. RNA, 2014 Apr. PMID 24550520, Free PMC Article
  4. Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin. Takagi M, et al. Cell, 2005 Oct 7. PMID 16213212
  5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables mRNA 3'-UTR binding ISO
Inferred from Sequence Orthology
more info
  
enables mRNA 5'-UTR binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
rRNA-processing protein UTP23 homolog
Names
UTP23, small subunit (SSU) processome component, homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001126266.1 → NP_001119738.1  rRNA-processing protein UTP23 homolog

    See identical proteins and their annotated locations for NP_001119738.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473950
    UniProtKB/TrEMBL
    A0A8I6A8S2, A6HRE2, B1WBU0
    Conserved Domains (1) summary
    cd09866
    Location:19 → 148
    PIN_Fcf1-Utp23-H; VapC-like PIN domain of rRNA-processing protein Fcf1- and Utp23-like homologs found in eukaryotes except fungi; similar to human rRNA-processing protein UTP23

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    85074713..85084766
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063263245.1 → XP_063119315.1  rRNA-processing protein UTP23 homolog isoform X1

    UniProtKB/TrEMBL
    A0A8I6A8S2, A6HRE2, B1WBU0

  2. XM_039078769.2 → XP_038934697.1  rRNA-processing protein UTP23 homolog isoform X1

    UniProtKB/TrEMBL
    A0A8I6A8S2, A6HRE2, B1WBU0
    Related
    ENSRNOP00000088155.2, ENSRNOT00000119001.2
    Conserved Domains (1) summary
    cd09866
    Location:19 → 148
    PIN_Fcf1-Utp23-H; VapC-like PIN domain of rRNA-processing protein Fcf1- and Utp23-like homologs found in eukaryotes except fungi; similar to human rRNA-processing protein UTP23

  3. XM_063263246.1 → XP_063119316.1  rRNA-processing protein UTP23 homolog isoform X2

    UniProtKB/TrEMBL
    A6HRE4
Nucleotide Protein Strain
Heading Accession and Version

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