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Gns glucosamine (N-acetyl)-6-sulfatase [ Rattus norvegicus (Norway rat) ]

Gene ID: 299825, updated on 27-Nov-2024

Summary

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Symbol
Gnsprovided by RGD
Full Name
glucosamine (N-acetyl)-6-sulfataseprovided by RGD
Primary source
RGD:1305877
See related
EnsemblRapid:ENSRNOG00000046159 AllianceGenome:RGD:1305877
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables N-acetylglucosamine-6-sulfatase activity; glycosaminoglycan binding activity; and sulfate binding activity. Involved in keratan sulfate catabolic process. Predicted to be located in lysosome. Human ortholog(s) of this gene implicated in mucopolysaccharidosis III and mucopolysaccharidosis type IIID. Orthologous to human GNS (glucosamine (N-acetyl)-6-sulfatase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 895.1), Spleen (RPKM 395.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Gns in Genome Data Viewer
Location:
7q22
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (58774625..58808650)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (56889148..56923173)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (63467027..63501054)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene TBC1 domain family, member 30 Neighboring gene uncharacterized LOC120093619 Neighboring gene Ras association domain family member 3 Neighboring gene uncharacterized LOC134479702

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Intralysosomal formation and metabolic fate of N-acetylglucosamine 6-sulfate from keratan sulfate. Fuchs W, et al. Eur J Biochem, 1985 Sep 16. PMID 3161730
  2. Genomic basis of mucopolysaccharidosis type IIID (MIM 252940) revealed by sequencing of GNS encoding N-acetylglucosamine-6-sulfatase. Mok A, et al. Genomics, 2003 Jan. PMID 12573255
  3. Sulphatase activities are regulated by the interaction of sulphatase-modifying factor 1 with SUMF2. Zito E, et al. EMBO Rep, 2005 Jul. PMID 15962010, Free PMC Article
  4. Sulfatases and sulfatase modifying factors: an exclusive and promiscuous relationship. Sardiello M, et al. Hum Mol Genet, 2005 Nov 1. PMID 16174644
  5. Loss of CLN7 results in depletion of soluble lysosomal proteins and impaired mTOR reactivation. Danyukova T, et al. Hum Mol Genet, 2018 May 15. PMID 29514215, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables N-acetylglucosamine-6-sulfatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables N-acetylglucosamine-6-sulfatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glycosaminoglycan binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glycosaminoglycan binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables sulfate binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sulfuric ester hydrolase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in keratan sulfate catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in lysosome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
N-acetylglucosamine-6-sulfatase
Names
N-acetylglucosamine-6-sulfatase-like
NP_001011989.1
NP_001401851.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001011989.2 → NP_001011989.1  N-acetylglucosamine-6-sulfatase isoform 2 precursor

    See identical proteins and their annotated locations for NP_001011989.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    A0A8J8YF65, Q5M918
    Conserved Domains (2) summary
    COG3119
    Location:35 → 496
    AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]
    cd16147
    Location:38 → 487
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)

  2. NM_001414922.1 → NP_001401851.1  N-acetylglucosamine-6-sulfatase isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    F7EQ81, F7F393, Q32KJ5
    Related
    ENSRNOP00000062823.4, ENSRNOT00000064349.5

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    58774625..58808650
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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