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Tle2 TLE family member 2, transcriptional corepressor [ Rattus norvegicus (Norway rat) ]

Gene ID: 299636, updated on 4-Jan-2025

Summary

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Official Symbol
Tle2provided by RGD
Official Full Name
TLE family member 2, transcriptional corepressorprovided by RGD
Primary source
RGD:1306665
See related
EnsemblRapid:ENSRNOG00000005874 AllianceGenome:RGD:1306665
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable transcription corepressor activity. Predicted to be involved in negative regulation of DNA-templated transcription and negative regulation of canonical Wnt signaling pathway. Predicted to be located in focal adhesion and nuclear body. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Orthologous to human TLE2 (TLE family member 2, transcriptional corepressor). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Kidney (RPKM 64.4), Adrenal (RPKM 45.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tle2 in Genome Data Viewer
Location:
7q11
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (8769815..8789493, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (8119049..8135385, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (10988536..11003957, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102551996 Neighboring gene TLE family member 6, subcortical maternal complex member Neighboring gene TLE family member 5, transcriptional modulator Neighboring gene G protein subunit alpha 11

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Groucho binds two conserved regions of LEF-1 for HDAC-dependent repression. Arce L, et al. BMC Cancer, 2009 May 21. PMID 19460168, Free PMC Article
  2. Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach. Böhm D, et al. Oncol Rep, 2012 Aug. PMID 22664934, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC124808

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
transducin-like enhancer protein 2
Names
transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)
transducin-like enhancer of split 2 homolog
transducin-like enhancer of split 2, homolog of Drosophila E(spl)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039013.1 → NP_001034102.1  transducin-like enhancer protein 2

    See identical proteins and their annotated locations for NP_001034102.1

    Status: PROVISIONAL

    Source sequence(s)
    BC100652
    UniProtKB/TrEMBL
    A0A8I6A8Q2, Q496Z7
    Related
    ENSRNOP00000057991.2, ENSRNOT00000061279.4
    Conserved Domains (4) summary
    COG2319
    Location:408 → 694
    WD40; WD40 repeat [General function prediction only]
    pfam03920
    Location:1 → 129
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    sd00039
    Location:413 → 452
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:409 → 693
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    8769815..8789493 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039078654.2 → XP_038934582.1  transducin-like enhancer protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K109, A6K868
    Conserved Domains (4) summary
    PHA03247
    Location:269 → 458
    PHA03247; large tegument protein UL36; Provisional
    sd00039
    Location:483 → 522
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:10 → 152
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    cl29593
    Location:479 → 763
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. XM_039078653.2 → XP_038934581.1  transducin-like enhancer protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K109, A6K868
    Conserved Domains (4) summary
    PHA03247
    Location:269 → 458
    PHA03247; large tegument protein UL36; Provisional
    sd00039
    Location:483 → 522
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:10 → 152
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    cl29593
    Location:479 → 763
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  3. XM_039078660.2 → XP_038934588.1  transducin-like enhancer protein 2 isoform X8

    UniProtKB/TrEMBL
    A0A0G2K109
    Conserved Domains (4) summary
    PHA03247
    Location:269 → 344
    PHA03247; large tegument protein UL36; Provisional
    sd00039
    Location:436 → 475
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:10 → 152
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    cl29593
    Location:432 → 716
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  4. XM_039078656.2 → XP_038934584.1  transducin-like enhancer protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K109, A6K868
    Conserved Domains (4) summary
    PHA03247
    Location:269 → 458
    PHA03247; large tegument protein UL36; Provisional
    sd00039
    Location:483 → 522
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:10 → 152
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    cl29593
    Location:479 → 763
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  5. XM_039078657.2 → XP_038934585.1  transducin-like enhancer protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K109, A6K868
    Conserved Domains (4) summary
    PHA03247
    Location:269 → 458
    PHA03247; large tegument protein UL36; Provisional
    sd00039
    Location:483 → 522
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:10 → 152
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    cl29593
    Location:479 → 763
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  6. XM_039078658.2 → XP_038934586.1  transducin-like enhancer protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A0G2K109
    Related
    ENSRNOP00000071657.2, ENSRNOT00000084006.3
    Conserved Domains (4) summary
    PHA03247
    Location:268 → 457
    PHA03247; large tegument protein UL36; Provisional
    sd00039
    Location:482 → 521
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:10 → 151
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    cl29593
    Location:478 → 762
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  7. XM_039078659.2 → XP_038934587.1  transducin-like enhancer protein 2 isoform X3

    UniProtKB/TrEMBL
    A0A0G2K109
    Conserved Domains (4) summary
    PHA03247
    Location:269 → 446
    PHA03247; large tegument protein UL36; Provisional
    sd00039
    Location:471 → 510
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:10 → 152
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    cl29593
    Location:467 → 751
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  8. XM_063263177.1 → XP_063119247.1  transducin-like enhancer protein 2 isoform X4

    UniProtKB/TrEMBL
    A0A0G2K109, A6K867

  9. XM_063263180.1 → XP_063119250.1  transducin-like enhancer protein 2 isoform X6

    UniProtKB/TrEMBL
    A0A0G2K109

  10. XM_063263178.1 → XP_063119248.1  transducin-like enhancer protein 2 isoform X4

    UniProtKB/TrEMBL
    A0A0G2K109, A6K867

  11. XM_063263181.1 → XP_063119251.1  transducin-like enhancer protein 2 isoform X7

    UniProtKB/TrEMBL
    A0A0G2K109

  12. XM_006240893.4 → XP_006240955.1  transducin-like enhancer protein 2 isoform X5

    UniProtKB/TrEMBL
    A0A0G2K109
    Conserved Domains (4) summary
    COG2319
    Location:454 → 740
    WD40; WD40 repeat [General function prediction only]
    pfam03920
    Location:1 → 128
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    sd00039
    Location:459 → 498
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:455 → 739
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  13. XM_006240889.4 → XP_006240951.1  transducin-like enhancer protein 2 isoform X4

    See identical proteins and their annotated locations for XP_006240951.1

    UniProtKB/TrEMBL
    A0A0G2K109, A6K867
    Related
    ENSRNOP00000086408.2, ENSRNOT00000115215.2
    Conserved Domains (4) summary
    COG2319
    Location:455 → 741
    WD40; WD40 repeat [General function prediction only]
    pfam03920
    Location:1 → 129
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    sd00039
    Location:460 → 499
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:456 → 740
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  14. XM_063263179.1 → XP_063119249.1  transducin-like enhancer protein 2 isoform X6

    UniProtKB/TrEMBL
    A0A0G2K109

  15. XM_039078664.2 → XP_038934592.1  transducin-like enhancer protein 2 isoform X10

    Conserved Domains (2) summary
    PHA03307
    Location:224 → 361
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam03920
    Location:10 → 152
    TLE_N; Groucho/TLE N-terminal Q-rich domain

  16. XM_039078661.2 → XP_038934589.1  transducin-like enhancer protein 2 isoform X9

    Conserved Domains (2) summary
    PHA03307
    Location:224 → 361
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam03920
    Location:10 → 152
    TLE_N; Groucho/TLE N-terminal Q-rich domain

RNA

  1. XR_005486568.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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