U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Abhd17a abhydrolase domain containing 17A, depalmitoylase [ Rattus norvegicus (Norway rat) ]

Gene ID: 299617, updated on 27-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Abhd17aprovided by RGD
Official Full Name
abhydrolase domain containing 17A, depalmitoylaseprovided by RGD
Primary source
RGD:1359682
See related
AllianceGenome:RGD:1359682
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Fam108a; upf0227; Fam108a1; RGD1359682
Summary
Enables palmitoyl-(protein) hydrolase activity. Involved in protein depalmitoylation; regulation of postsynapse organization; and regulation of protein localization. Located in plasma membrane; postsynaptic density; and recycling endosome membrane. Is active in glutamatergic synapse; postsynaptic density membrane; and postsynaptic recycling endosome membrane. Orthologous to human ABHD17A (abhydrolase domain containing 17A, depalmitoylase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 94.8), Adrenal (RPKM 79.0) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Abhd17a in Genome Data Viewer
Location:
7q11
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (9775016..9781447)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (9124332..9132762)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (11992543..12000978)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene secretory carrier membrane protein 4 Neighboring gene large ribosomal subunit protein eL31-like Neighboring gene adenosine deaminase, tRNA-specific 3 Neighboring gene KLF transcription factor 16 Neighboring gene uncharacterized LOC120093775 Neighboring gene RNA exonuclease 1 homolog

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. ABHD17 proteins are novel protein depalmitoylases that regulate N-Ras palmitate turnover and subcellular localization. Lin DT, et al. Elife, 2015 Dec 23. PMID 26701913, Free PMC Article
  2. Dynamic Palmitoylation Targets MAP6 to the Axon to Promote Microtubule Stabilization during Neuronal Polarization. Tortosa E, et al. Neuron, 2017 May 17. PMID 28521134
  3. Identification of PSD-95 Depalmitoylating Enzymes. Yokoi N, et al. J Neurosci, 2016 Jun 15. PMID 27307232, Free PMC Article
  4. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article
  5. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC94549

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables palmitoyl-(protein) hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables palmitoyl-(protein) hydrolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables palmitoyl-(protein) hydrolase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of NLRP3 inflammasome complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein localization to microtubule IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein localization to endosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein depalmitoylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein depalmitoylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of postsynapse organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of postsynapse organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of postsynapse organization IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in regulation of postsynapse organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in dendritic spine IEA
Inferred from Electronic Annotation
more info
  
is_active_in endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endosome membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic density membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic density membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in postsynaptic recycling endosome membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic recycling endosome membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in recycling endosome membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
alpha/beta hydrolase domain-containing protein 17A
Names
abhydrolase domain-containing protein 17A
abhydrolase domain-containing protein FAM108A
family with sequence similarity 108, member A1
protein ABHD17A
NP_001006984.1
XP_008763312.1
XP_063119243.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001006983.1 → NP_001006984.1  alpha/beta hydrolase domain-containing protein 17A

    See identical proteins and their annotated locations for NP_001006984.1

    Status: PROVISIONAL

    Source sequence(s)
    BC083686
    UniProtKB/Swiss-Prot
    Q5XIJ5
    UniProtKB/TrEMBL
    A6K8J3, A6K8J4
    Conserved Domains (1) summary
    COG1073
    Location:113 → 305
    FrsA; Fermentation-respiration switch protein FrsA, has esterase activity, DUF1100 family [Signal transduction mechanisms]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    9775016..9781447
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008765090.4 → XP_008763312.1  alpha/beta hydrolase domain-containing protein 17A isoform X1

    See identical proteins and their annotated locations for XP_008763312.1

    UniProtKB/Swiss-Prot
    Q5XIJ5
    UniProtKB/TrEMBL
    A6K8J3, A6K8J4
    Conserved Domains (1) summary
    COG1073
    Location:113 → 305
    FrsA; Fermentation-respiration switch protein FrsA, has esterase activity, DUF1100 family [Signal transduction mechanisms]

  2. XM_063263173.1 → XP_063119243.1  alpha/beta hydrolase domain-containing protein 17A isoform X1

    UniProtKB/Swiss-Prot
    Q5XIJ5
    UniProtKB/TrEMBL
    A6K8J3
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5XIJ5.1 GenPept UniProtKB/Swiss-Prot:Q5XIJ5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous