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Akap8l A-kinase anchoring protein 8 like [ Rattus norvegicus (Norway rat) ]

Gene ID: 299569, updated on 27-Nov-2024

Summary

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Official Symbol
Akap8lprovided by RGD
Official Full Name
A-kinase anchoring protein 8 likeprovided by RGD
Primary source
RGD:1359200
See related
EnsemblRapid:ENSRNOG00000006355 AllianceGenome:RGD:1359200
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable histone deacetylase binding activity; lamin binding activity; and protein kinase A regulatory subunit binding activity. Predicted to be involved in several processes, including cell cycle G2/M phase transition; mitotic chromosome condensation; and regulation of mRNA export from nucleus. Predicted to be located in chromatin; cytoplasm; and nuclear speck. Predicted to be part of ribonucleoprotein complex. Predicted to be active in nuclear matrix. Orthologous to human AKAP8L (A-kinase anchoring protein 8 like). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 171.9), Lung (RPKM 156.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Akap8l in Genome Data Viewer
Location:
7q11
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (11983215..12012843, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (11332671..11362287, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (14340168..14369835, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene bromodomain containing 4 Neighboring gene uncharacterized LOC134479823 Neighboring gene A-kinase anchoring protein 8 Neighboring gene uncharacterized LOC134479821 Neighboring gene WIZ zinc finger

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Protein kinase A associates with HA95 and affects transcriptional coactivation by Epstein-Barr virus nuclear proteins. Han I, et al. Mol Cell Biol, 2002 Apr. PMID 11884601, Free PMC Article
  2. Mapping the functional domains of HAP95, a protein that binds RNA helicase A and activates the constitutive transport element of type D retroviruses. Yang JP, et al. J Biol Chem, 2001 Aug 17. PMID 11402034
  3. Involvement of the catalytic subunit of protein kinase A and of HA95 in pre-mRNA splicing. Kvissel AK, et al. Exp Cell Res, 2007 Aug 1. PMID 17594903
  4. HA95 is a protein of the chromatin and nuclear matrix regulating nuclear envelope dynamics. Martins SB, et al. J Cell Sci, 2000 Nov. PMID 11034899
  5. Interaction of the nuclear matrix protein NAKAP with HypA and huntingtin: implications for nuclear toxicity in Huntington's disease pathogenesis. Sayer JA, et al. Neuromolecular Med, 2005. PMID 16391387

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables histone deacetylase binding ISO
Inferred from Sequence Orthology
more info
  
enables lamin binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase A regulatory subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cell cycle G2/M phase transition ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA processing ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic chromosome condensation ISO
Inferred from Sequence Orthology
more info
  
involved_in nuclear membrane disassembly ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mRNA export from nucleus ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in chromatin ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nuclear matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear matrix ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
A-kinase anchor protein 8-like
Names
A kinase (PRKA) anchor protein 8-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013946.1 → NP_001013968.1  A-kinase anchor protein 8-like

    See identical proteins and their annotated locations for NP_001013968.1

    Status: PROVISIONAL

    Source sequence(s)
    BC085785
    UniProtKB/TrEMBL
    A0A0G2K0P0, A0A9K3Y6N0, F1LP74, Q5U306
    Related
    ENSRNOP00000092015.1, ENSRNOT00000110147.2
    Conserved Domains (1) summary
    pfam04988
    Location:390 → 554
    AKAP95; A-kinase anchoring protein 95 (AKAP95)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    11983215..12012843 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006241054.3 → XP_006241116.1  A-kinase anchor protein 8-like isoform X1

    UniProtKB/TrEMBL
    A0A0G2K0P0
    Related
    ENSRNOP00000008560.7, ENSRNOT00000008560.9
    Conserved Domains (1) summary
    pfam04988
    Location:356 → 520
    AKAP95; A-kinase anchoring protein 95 (AKAP95)

  2. XM_063263156.1 → XP_063119226.1  A-kinase anchor protein 8-like isoform X3

  3. XM_006241055.4 → XP_006241117.1  A-kinase anchor protein 8-like isoform X2

    Conserved Domains (1) summary
    pfam04988
    Location:390 → 513
    AKAP95; A-kinase anchoring protein 95 (AKAP95)

  4. XM_039078627.2 → XP_038934555.1  A-kinase anchor protein 8-like isoform X5

  5. XM_063263158.1 → XP_063119228.1  A-kinase anchor protein 8-like isoform X5

  6. XM_063263159.1 → XP_063119229.1  A-kinase anchor protein 8-like isoform X7

  7. XM_039078629.2 → XP_038934557.1  A-kinase anchor protein 8-like isoform X6

  8. XM_063263157.1 → XP_063119227.1  A-kinase anchor protein 8-like isoform X4

RNA

  1. XR_001838673.2 RNA Sequence

  2. XR_005486554.2 RNA Sequence

  3. XR_010052950.1 RNA Sequence

  4. XR_010052949.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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