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SERTAD3 SERTA domain containing 3 [ Homo sapiens (human) ]

Gene ID: 29946, updated on 27-Nov-2024

Summary

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Official Symbol
SERTAD3provided by HGNC
Official Full Name
SERTA domain containing 3provided by HGNC
Primary source
HGNC:HGNC:17931
See related
Ensembl:ENSG00000167565 MIM:612125; AllianceGenome:HGNC:17931
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RBT1
Summary
The protein encoded by this gene was identified in a yeast two-hybrid assay employing the second subunit of human replication protein A as bait. It is localized to the nucleus and its expression is significantly higher in cancer cell lines compared to normal cell lines. This protein has also been shown to be a strong transcriptional co-activator. Alternative splicing has been observed at this locus and two variants, both encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in placenta (RPKM 11.9), prostate (RPKM 10.6) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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See SERTAD3 in Genome Data Viewer
Location:
19q13.2
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (40440844..40444335, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (43261506..43264994, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (40946751..40950242, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene periaxin Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10621 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14650 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10622 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14651 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:40915393-40915986 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:40915987-40916578 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:40920095-40920743 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:40926600-40927100 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10623 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:40930422-40931224 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10624 Neighboring gene SERTA domain containing 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:40939147-40939975 Neighboring gene CRISPRi-validated cis-regulatory element chr19.4185 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10626 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10627 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10628 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10629 Neighboring gene SERTAD3 antisense RNA 1 Neighboring gene biliverdin reductase B Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14655

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Overexpression of SERTAD3, a putative oncogene located within the 19q13 amplicon, induces E2F activity and promotes tumor growth. Darwish H, et al. Oncogene, 2007 Jun 21. PMID 17260023
  2. Type-IInterferon-Inducible SERTAD3 Inhibits Influenza A Virus Replication by Blocking the Assembly of Viral RNA Polymerase Complex. Sun N, et al. Cell Rep, 2020 Nov 3. PMID 33147462
  3. RBT1, a novel transcriptional co-activator, binds the second subunit of replication protein A. Cho JM, et al. Nucleic Acids Res, 2000 Sep 15. PMID 10982866, Free PMC Article
  4. SEI family of nuclear factors regulates p53-dependent transcriptional activation. Watanabe-Fukunaga R, et al. Genes Cells, 2005 Aug. PMID 16098148
  5. TRIP-Br: a novel family of PHD zinc finger- and bromodomain-interacting proteins that regulate the transcriptional activity of E2F-1/DP-1. Hsu SI, et al. EMBO J, 2001 May 1. PMID 11331592, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Type-IInterferon-Inducible SERTAD3 Inhibits Influenza A Virus Replication by Blocking the Assembly of Viral RNA Polymerase Complex.
    Title: Type-IInterferon-Inducible SERTAD3 Inhibits Influenza A Virus Replication by Blocking the Assembly of Viral RNA Polymerase Complex.
  2. Transduction of stably expressed human SERTAD3 induces cell transformation in vitro and tumor formation in mice via a transcription factor E2F-dependent mechanism.
    Title: Overexpression of SERTAD3, a putative oncogene located within the 19q13 amplicon, induces E2F activity and promotes tumor growth.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of cell growth IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
SERTA domain-containing protein 3
Names
RPA-binding trans-activator
replication protein-binding trans-activator

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013368.4 → NP_037500.2  SERTA domain-containing protein 3

    See identical proteins and their annotated locations for NP_037500.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AC010271, AF192529, AW242302, BC014061
    Consensus CDS
    CCDS12558.1
    UniProtKB/Swiss-Prot
    B3KQB3, Q96CQ2, Q9UJW9
    UniProtKB/TrEMBL
    M0QXL4
    Related
    ENSP00000375882.3, ENST00000392028.8
    Conserved Domains (1) summary
    pfam06031
    Location:33 → 66
    SERTA; SERTA motif

  2. NM_203344.3 → NP_976219.1  SERTA domain-containing protein 3

    See identical proteins and their annotated locations for NP_976219.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AW242302, BC050643
    Consensus CDS
    CCDS12558.1
    UniProtKB/Swiss-Prot
    B3KQB3, Q96CQ2, Q9UJW9
    UniProtKB/TrEMBL
    M0QXL4
    Related
    ENSP00000325414.2, ENST00000322354.4
    Conserved Domains (1) summary
    pfam06031
    Location:33 → 66
    SERTA; SERTA motif

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    40440844..40444335 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047438716.1 → XP_047294672.1  SERTA domain-containing protein 3 isoform X1

  2. XM_006723179.4 → XP_006723242.1  SERTA domain-containing protein 3 isoform X2

    See identical proteins and their annotated locations for XP_006723242.1

    UniProtKB/Swiss-Prot
    B3KQB3, Q96CQ2, Q9UJW9
    UniProtKB/TrEMBL
    M0QXL4
    Related
    ENSP00000469245.1, ENST00000599706.1
    Conserved Domains (1) summary
    pfam06031
    Location:33 → 66
    SERTA; SERTA motif

  3. XM_047438717.1 → XP_047294673.1  SERTA domain-containing protein 3 isoform X1

  4. XM_047438718.1 → XP_047294674.1  SERTA domain-containing protein 3 isoform X2

    UniProtKB/Swiss-Prot
    B3KQB3, Q96CQ2, Q9UJW9

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    43261506..43264994 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054320771.1 → XP_054176746.1  SERTA domain-containing protein 3 isoform X1

  2. XM_054320774.1 → XP_054176749.1  SERTA domain-containing protein 3 isoform X2

    UniProtKB/Swiss-Prot
    B3KQB3, Q96CQ2, Q9UJW9

  3. XM_054320772.1 → XP_054176747.1  SERTA domain-containing protein 3 isoform X1

  4. XM_054320773.1 → XP_054176748.1  SERTA domain-containing protein 3 isoform X2

    UniProtKB/Swiss-Prot
    B3KQB3, Q96CQ2, Q9UJW9
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UJW9.2 GenPept UniProtKB/Swiss-Prot:Q9UJW9

Gene LinkOut

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