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Arel1 apoptosis resistant E3 ubiquitin protein ligase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 299197, updated on 27-Nov-2024

Summary

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Official Symbol
Arel1provided by RGD
Official Full Name
apoptosis resistant E3 ubiquitin protein ligase 1provided by RGD
Primary source
RGD:1307597
See related
EnsemblRapid:ENSRNOG00000004382 AllianceGenome:RGD:1307597
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1307597
Summary
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in several processes, including negative regulation of apoptotic process; protein polyubiquitination; and ubiquitin-dependent protein catabolic process. Predicted to be active in cytosol. Orthologous to human AREL1 (apoptosis resistant E3 ubiquitin protein ligase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 94.0), Kidney (RPKM 86.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Arel1 in Genome Data Viewer
Location:
6q31
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (110296072..110348751, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (104560556..104617712, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (108630790..108796096, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene iron-sulfur cluster assembly 2 Neighboring gene latent transforming growth factor beta binding protein 2 Neighboring gene Fcf1 rRNA-processing protein Neighboring gene eukaryotic translation initiation factor 2 subunit 2-like Neighboring gene U6 snRNA-associated Sm-like protein LSm5 Neighboring gene YLP motif containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. KIAA0317 regulates pulmonary inflammation through SOCS2 degradation. Lear TB, et al. JCI Insight, 2019 Oct 3. PMID 31578312, Free PMC Article
  2. Identification of a novel anti-apoptotic E3 ubiquitin ligase that ubiquitinates antagonists of inhibitor of apoptosis proteins SMAC, HtrA2, and ARTS. Kim JB, et al. J Biol Chem, 2013 Apr 26. PMID 23479728, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K11-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K33-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
apoptosis-resistant E3 ubiquitin protein ligase 1
NP_001100214.1
XP_006240395.1
XP_008762976.1
XP_017449586.1
XP_038967965.1
XP_038967966.1
XP_038967967.1
XP_063117810.1
XP_063117812.1
XP_063117813.1
XP_063117814.1
XP_063117815.1
XP_063117816.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106744.1 → NP_001100214.1  apoptosis-resistant E3 ubiquitin protein ligase 1 isoform 1

    See identical proteins and their annotated locations for NP_001100214.1

    Status: VALIDATED

    Source sequence(s)
    CH473982
    UniProtKB/TrEMBL
    A6JDZ1, D3ZVC4
    Related
    ENSRNOP00000006240.5, ENSRNOT00000006240.8
    Conserved Domains (2) summary
    smart00119
    Location:486 → 820
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    pfam00630
    Location:56 → 154
    Filamin; Filamin/ABP280 repeat

  2. NM_001433934.1 → NP_001420863.1  apoptosis-resistant E3 ubiquitin protein ligase 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006

  3. NM_001433935.1 → NP_001420864.1  apoptosis-resistant E3 ubiquitin protein ligase 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006

  4. NM_001433936.1 → NP_001420865.1  apoptosis-resistant E3 ubiquitin protein ligase 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006

  5. NM_001433937.1 → NP_001420866.1  apoptosis-resistant E3 ubiquitin protein ligase 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006

  6. NM_001433938.1 → NP_001420867.1  apoptosis-resistant E3 ubiquitin protein ligase 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006

  7. NM_001433939.1 → NP_001420868.1  apoptosis-resistant E3 ubiquitin protein ligase 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006

  8. NM_001433940.1 → NP_001420869.1  apoptosis-resistant E3 ubiquitin protein ligase 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    110296072..110348751 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017594097.3 → XP_017449586.1  apoptosis-resistant E3 ubiquitin protein ligase 1 isoform X2

    Conserved Domains (3) summary
    smart00119
    Location:476 → 810
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:454 → 811
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00630
    Location:56 → 144
    Filamin; Filamin/ABP280 repeat

  2. XM_008764754.4 → XP_008762976.1  apoptosis-resistant E3 ubiquitin protein ligase 1 isoform X1

    UniProtKB/TrEMBL
    A6JDZ1, D3ZVC4
    Conserved Domains (2) summary
    smart00119
    Location:486 → 820
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    pfam00630
    Location:56 → 154
    Filamin; Filamin/ABP280 repeat

  3. XM_063261743.1 → XP_063117813.1  apoptosis-resistant E3 ubiquitin protein ligase 1 isoform X1

    UniProtKB/TrEMBL
    A6JDZ1, D3ZVC4

  4. XM_063261742.1 → XP_063117812.1  apoptosis-resistant E3 ubiquitin protein ligase 1 isoform X1

    UniProtKB/TrEMBL
    A6JDZ1, D3ZVC4

  5. XM_039112038.2 → XP_038967966.1  apoptosis-resistant E3 ubiquitin protein ligase 1 isoform X1

    UniProtKB/TrEMBL
    A6JDZ1, D3ZVC4
    Conserved Domains (2) summary
    smart00119
    Location:486 → 820
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    pfam00630
    Location:56 → 154
    Filamin; Filamin/ABP280 repeat

  6. XM_039112037.2 → XP_038967965.1  apoptosis-resistant E3 ubiquitin protein ligase 1 isoform X1

    UniProtKB/TrEMBL
    A6JDZ1, D3ZVC4
    Conserved Domains (2) summary
    smart00119
    Location:486 → 820
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    pfam00630
    Location:56 → 154
    Filamin; Filamin/ABP280 repeat

  7. XM_063261744.1 → XP_063117814.1  apoptosis-resistant E3 ubiquitin protein ligase 1 isoform X2

  8. XM_063261740.1 → XP_063117810.1  apoptosis-resistant E3 ubiquitin protein ligase 1 isoform X1

    UniProtKB/TrEMBL
    A6JDZ1, D3ZVC4

  9. XM_039112039.2 → XP_038967967.1  apoptosis-resistant E3 ubiquitin protein ligase 1 isoform X1

    UniProtKB/TrEMBL
    A6JDZ1, D3ZVC4
    Conserved Domains (2) summary
    smart00119
    Location:486 → 820
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    pfam00630
    Location:56 → 154
    Filamin; Filamin/ABP280 repeat

  10. XM_063261745.1 → XP_063117815.1  apoptosis-resistant E3 ubiquitin protein ligase 1 isoform X2

  11. XM_006240333.4 → XP_006240395.1  apoptosis-resistant E3 ubiquitin protein ligase 1 isoform X1

    See identical proteins and their annotated locations for XP_006240395.1

    UniProtKB/TrEMBL
    A6JDZ1, D3ZVC4
    Conserved Domains (2) summary
    smart00119
    Location:486 → 820
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    pfam00630
    Location:56 → 154
    Filamin; Filamin/ABP280 repeat

  12. XM_063261746.1 → XP_063117816.1  apoptosis-resistant E3 ubiquitin protein ligase 1 isoform X2

RNA

  1. XR_010052071.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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