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Rhoj ras homolog family member J [ Rattus norvegicus (Norway rat) ]

Gene ID: 299145, updated on 4-Jan-2025

Summary

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Official Symbol
Rhojprovided by RGD
Official Full Name
ras homolog family member Jprovided by RGD
Primary source
RGD:1310528
See related
EnsemblRapid:ENSRNOG00000021919 AllianceGenome:RGD:1310528
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable GTP binding activity; GTPase activity; and protein kinase binding activity. Predicted to be involved in several processes, including Cdc42 protein signal transduction; positive regulation of cell migration involved in sprouting angiogenesis; and regulation of sprouting angiogenesis. Predicted to act upstream of or within several processes, including Rho protein signal transduction; regulation of cell shape; and retina vasculature morphogenesis in camera-type eye. Predicted to be active in plasma membrane. Orthologous to human RHOJ (ras homolog family member J). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Uterus (RPKM 201.0), Lung (RPKM 180.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rhoj in Genome Data Viewer
Location:
6q24
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (99771104..99853366)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (94035307..94117642)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (98284361..98367122)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102550910 Neighboring gene synaptotagmin 16 Neighboring gene potassium voltage-gated channel subfamily H member 5 Neighboring gene protein phosphatase 2 regulatory subunit B', epsilon Neighboring gene glycoprotein hormone subunit beta 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. TCL/RhoJ Plasma Membrane Localization and Nucleotide Exchange Is Coordinately Regulated by Amino Acids within the N Terminus and a Distal Loop Region. Ackermann KL, et al. J Biol Chem, 2016 Nov 4. PMID 27660391, Free PMC Article
  2. RhoJ is an endothelial cell-restricted Rho GTPase that mediates vascular morphogenesis and is regulated by the transcription factor ERG. Yuan L, et al. Blood, 2011 Jul 28. PMID 21628409, Free PMC Article
  3. High-fat diet alters PP2A, TC10, and CIP4 expression in visceral adipose tissue of rats. Jun HS, et al. Obesity (Silver Spring), 2008 Jun. PMID 18388891
  4. Dysregulation of endothelial colony-forming cell function by a negative feedback loop of circulating miR-146a and -146b in cardiovascular disease patients. Chang TY, et al. PLoS One, 2017. PMID 28727754, Free PMC Article
  5. Role of glutamine synthetase in angiogenesis beyond glutamine synthesis. Eelen G, et al. Nature, 2018 Sep. PMID 30158707

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC106003

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding ISO
Inferred from Sequence Orthology
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in Cdc42 protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within Rho protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in establishment of cell polarity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cell migration involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of cell shape ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of endothelial cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within retina vasculature morphogenesis in camera-type eye ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
rho-related GTP-binding protein RhoJ
Names
TC10-like Rho GTPase
ras homolog gene family, member J

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008320.1 → NP_001008321.1  rho-related GTP-binding protein RhoJ

    See identical proteins and their annotated locations for NP_001008321.1

    Status: PROVISIONAL

    Source sequence(s)
    BC086525
    UniProtKB/TrEMBL
    A0A8I5ZTS1, Q5RJS2
    Related
    ENSRNOP00000030536.3, ENSRNOT00000031979.6
    Conserved Domains (1) summary
    cl38936
    Location:22 → 195
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    99771104..99853366
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039112008.2 → XP_038967936.1  rho-related GTP-binding protein RhoJ isoform X1

    UniProtKB/TrEMBL
    A0A8I6AJ60
    Related
    ENSRNOP00000095177.1, ENSRNOT00000099066.2
    Conserved Domains (1) summary
    cl38936
    Location:22 → 167
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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