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Itgb1bp1 integrin subunit beta 1 binding protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 298914, updated on 27-Nov-2024

Summary

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Official Symbol
Itgb1bp1provided by RGD
Official Full Name
integrin subunit beta 1 binding protein 1provided by RGD
Primary source
RGD:1307810
See related
EnsemblRapid:ENSRNOG00000059402 AllianceGenome:RGD:1307810
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable GDP-dissociation inhibitor activity; integrin binding activity; and protein kinase binding activity. Predicted to be involved in several processes, including regulation of cell migration; regulation of cell-substrate adhesion; and regulation of signal transduction. Predicted to be located in several cellular components, including centriolar satellite; nuclear body; and perinuclear region of cytoplasm. Predicted to be active in several cellular components, including cytoskeleton; lamellipodium; and ruffle. Orthologous to human ITGB1BP1 (integrin subunit beta 1 binding protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 133.2), Muscle (RPKM 125.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Itgb1bp1 in Genome Data Viewer
Location:
6q16
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (46549994..46564735, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (40820693..40836074, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (43348927..43363633, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479349 Neighboring gene ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 Neighboring gene U6 spliceosomal RNA Neighboring gene small nucleolar RNA SNORA21 Neighboring gene cleavage and polyadenylation specific factor 3 Neighboring gene isoamyl acetate hydrolyzing esterase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Cell adaptive response to extracellular matrix density is controlled by ICAP-1-dependent beta1-integrin affinity. Millon-Frémillon A, et al. J Cell Biol, 2008 Jan 28. PMID 18227284, Free PMC Article
  2. ICAP-1, a novel beta1 integrin cytoplasmic domain-associated protein, binds to a conserved and functionally important NPXY sequence motif of beta1 integrin. Chang DD, et al. J Cell Biol, 1997 Sep 8. PMID 9281591, Free PMC Article
  3. Integrin Cytoplasmic domain-Associated Protein-1 (ICAP-1) promotes migration of myoblasts and affects focal adhesions. Alvarez B, et al. J Cell Physiol, 2008 Feb. PMID 17654484
  4. Integrin cytoplasmic domain-associated protein-1 (ICAP-1) interacts with the ROCK-I kinase at the plasma membrane. Stroeken PJ, et al. J Cell Physiol, 2006 Sep. PMID 16741948
  5. Disruption of focal adhesions by integrin cytoplasmic domain-associated protein-1 alpha. Bouvard D, et al. J Biol Chem, 2003 Feb 21. PMID 12473654

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GDP-dissociation inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables integrin binding ISO
Inferred from Sequence Orthology
more info
  
enables kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in activation of protein kinase B activity ISO
Inferred from Sequence Orthology
more info
  
involved_in blood vessel diameter maintenance ISO
Inferred from Sequence Orthology
more info
  
involved_in blood vessel endothelial cell proliferation involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to fibroblast growth factor stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to vascular endothelial growth factor stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in integrin activation ISO
Inferred from Sequence Orthology
more info
  
involved_in integrin-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in myoblast migration ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell adhesion involved in substrate-bound cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell migration involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of fibroblast migration ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of focal adhesion assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein targeting to membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of substrate adhesion-dependent cell spreading ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of endothelial cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of focal adhesion assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein targeting to membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of stress fiber assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in receptor clustering ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell adhesion mediated by integrin ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of integrin-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in tube formation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell periphery ISO
Inferred from Sequence Orthology
more info
  
located_in centriolar satellite ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
NOT located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
  
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in ruffle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
integrin beta-1-binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106719.2 → NP_001100189.1  integrin beta-1-binding protein 1

    See identical proteins and their annotated locations for NP_001100189.1

    Status: PROVISIONAL

    Source sequence(s)
    BC169104
    UniProtKB/TrEMBL
    A0A0G2K157, A0A8I6GLU4, A6HAV6, B5DFL3
    Related
    ENSRNOP00000071708.3, ENSRNOT00000092192.3
    Conserved Domains (1) summary
    cl17171
    Location:1 → 199
    PH-like; Pleckstrin homology-like domain

  2. NM_001434252.1 → NP_001421181.1  integrin beta-1-binding protein 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006

  3. NM_001434253.1 → NP_001421182.1  integrin beta-1-binding protein 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006

  4. NM_001434254.1 → NP_001421183.1  integrin beta-1-binding protein 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006

  5. NM_001434255.1 → NP_001421184.1  integrin beta-1-binding protein 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006

  6. NM_001434256.1 → NP_001421185.1  integrin beta-1-binding protein 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006

  7. NM_001434257.1 → NP_001421186.1  integrin beta-1-binding protein 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    46549994..46564735 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006239980.5 → XP_006240042.1  integrin beta-1-binding protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K157, A0A8I6GLU4, A6HAV6, B5DFL3
    Conserved Domains (1) summary
    cl17171
    Location:1 → 199
    PH-like; Pleckstrin homology-like domain

  2. XM_039111953.2 → XP_038967881.1  integrin beta-1-binding protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K157, A0A8I6GLU4, A6HAV6, B5DFL3
    Conserved Domains (1) summary
    cl17171
    Location:1 → 199
    PH-like; Pleckstrin homology-like domain

  3. XM_039111951.2 → XP_038967879.1  integrin beta-1-binding protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K157, A0A8I6GLU4, A6HAV6, B5DFL3
    Conserved Domains (1) summary
    cl17171
    Location:1 → 199
    PH-like; Pleckstrin homology-like domain

  4. XM_006239979.5 → XP_006240041.1  integrin beta-1-binding protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K157, A0A8I6GLU4, A6HAV6, B5DFL3
    Conserved Domains (1) summary
    cl17171
    Location:1 → 199
    PH-like; Pleckstrin homology-like domain

  5. XM_006239981.5 → XP_006240043.1  integrin beta-1-binding protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K157, A0A8I6GLU4, A6HAV6, B5DFL3
    Conserved Domains (1) summary
    cl17171
    Location:1 → 199
    PH-like; Pleckstrin homology-like domain

  6. XM_063261656.1 → XP_063117726.1  integrin beta-1-binding protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6GLU4, A6HAV6, B5DFL3

  7. XM_039111952.2 → XP_038967880.1  integrin beta-1-binding protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K157, A0A8I6GLU4, A6HAV6, B5DFL3
    Conserved Domains (1) summary
    cl17171
    Location:1 → 199
    PH-like; Pleckstrin homology-like domain
Nucleotide Protein Strain
Heading Accession and Version

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