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Ccnl2 cyclin L2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 298686, updated on 27-Nov-2024

Summary

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Official Symbol
Ccnl2provided by RGD
Official Full Name
cyclin L2provided by RGD
Primary source
RGD:1309149
See related
EnsemblRapid:ENSRNOG00000018691 AllianceGenome:RGD:1309149
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Predicted to be involved in regulation of RNA splicing. Predicted to be located in nucleoplasm. Predicted to be part of cyclin-dependent protein kinase holoenzyme complex. Predicted to be active in nucleus. Orthologous to human CCNL2 (cyclin L2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 300.9), Thymus (RPKM 292.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ccnl2 in Genome Data Viewer
Location:
5q36
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (171698951..171711037)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (166416940..166428997)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (173256301..173268279)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 65 Neighboring gene mitochondrial ribosomal protein L20 Neighboring gene uncharacterized LOC134487049 Neighboring gene uncharacterized LOC134487050 Neighboring gene aurora kinase A interacting protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification and characterization of the CDK12/cyclin L1 complex involved in alternative splicing regulation. Chen HH, et al. Mol Cell Biol, 2006 Apr. PMID 16537916, Free PMC Article
  2. Characterization of cyclin L1 as an immobile component of the splicing factor compartment. Herrmann A, et al. FASEB J, 2007 Oct. PMID 17494991
  3. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Gibbs RA, et al. Nature, 2004 Apr 1. PMID 15057822
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cyclin-dependent protein serine/threonine kinase regulator activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of RNA splicing ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of cyclin-dependent protein kinase holoenzyme complex IEA
Inferred from Electronic Annotation
more info
  
part_of cyclin-dependent protein kinase holoenzyme complex ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cyclin-L2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001401305.2 → NP_001388234.1  cyclin-L2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/Swiss-Prot
    Q5I0H5

  2. NM_001401307.2 → NP_001388236.1  cyclin-L2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    Related
    ENSRNOP00000025531.5, ENSRNOT00000025531.8

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    171698951..171711037
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006239544.5 → XP_006239606.1  cyclin-L2 isoform X1

    UniProtKB/TrEMBL
    A6IUS7
    Related
    ENSRNOP00000068952.3, ENSRNOT00000089936.3
    Conserved Domains (2) summary
    cd20590
    Location:33 → 188
    CYCLIN_CCNL2_rpt1; first cyclin box found in cyclin-2 (CCNL2) and similar proteins
    cd20593
    Location:193 → 315
    CYCLIN_CCNL2_rpt2; second cyclin box found in cyclin-2 (CCNL2) and similar proteins

  2. XM_039109721.2 → XP_038965649.1  cyclin-L2 isoform X2

    UniProtKB/TrEMBL
    A0A8I5Y5M3
    Related
    ENSRNOP00000077305.2, ENSRNOT00000096422.2
    Conserved Domains (2) summary
    cd20593
    Location:168 → 290
    CYCLIN_CCNL2_rpt2; second cyclin box found in cyclin-2 (CCNL2) and similar proteins
    cl40454
    Location:33 → 163
    CYCLIN_SF; Cyclin box fold superfamily

  3. XM_063287498.1 → XP_063143568.1  cyclin-L2 isoform X3

  4. XM_063287500.1 → XP_063143570.1  cyclin-L2 isoform X5

  5. XM_063287499.1 → XP_063143569.1  cyclin-L2 isoform X4

RNA

  1. XR_005504417.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5I0H5.2 GenPept UniProtKB/Swiss-Prot:Q5I0H5

Gene LinkOut

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