Sh3bgrl3 SH3 domain binding glutamate-rich protein like 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sh3bgrl3provided by RGD
Official Full Name: SH3 domain binding glutamate-rich protein like 3provided by RGD
Primary source: RGD:1308118
See related: AllianceGenome:RGD:1308118
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: TIP-B1
Summary: Predicted to be involved in cytoskeleton organization. Located in cytosol. Orthologous to human SH3BGRL3 (SH3 domain binding glutamate rich protein like 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 297.2), Spleen (RPKM 275.0) and 9 other tissues See more
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 5q36

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (151637897..151639270, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (146354152..146355525, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (152357270..152358643, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Nickel(II) treatment down-regulated Sh3bgrl3 expression.
Title: Differential gene expression in nickel(II)-treated normal rat kidney cells.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

NoName (e-PCR)
- UniSTS:235062

AI173504 (e-PCR)
- UniSTS:159306

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
NOT enables glutathione transferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in cytoskeleton organization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nuclear body	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in ruffle membrane	IEA Inferred from Electronic Annotation more info
located_in ruffle membrane	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: SH3 domain-binding glutamic acid-rich-like protein 3

Names: SH3 domain binding glutamic acid-rich protein-like 3; TNF inhibitory protein B1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106688.1 → NP_001100158.1 SH3 domain-binding glutamic acid-rich-like protein 3

See identical proteins and their annotated locations for NP_001100158.1

Status: PROVISIONAL

Source sequence(s)

CH473968

UniProtKB/Swiss-Prot

B2RZ27

UniProtKB/TrEMBL

A6IT06

Conserved Domains (1) summary

pfam04908
Location:2 → 93

SH3BGR; SH3-binding, glutamic acid-rich protein