U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Dhdds dehydrodolichyl diphosphate synthase subunit [ Rattus norvegicus (Norway rat) ]

Gene ID: 298541, updated on 27-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Dhddsprovided by RGD
Official Full Name
dehydrodolichyl diphosphate synthase subunitprovided by RGD
Primary source
RGD:1311560
See related
EnsemblRapid:ENSRNOG00000014665 AllianceGenome:RGD:1311560
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to contribute to dehydrodolichyl diphosphate synthase activity and polyprenyltransferase activity. Predicted to be involved in dolichyl diphosphate biosynthetic process and polyprenol biosynthetic process. Predicted to be part of dehydrodolichyl diphosphate synthase complex. Predicted to be active in endoplasmic reticulum. Human ortholog(s) of this gene implicated in developmental delay and seizures with or without movement abnormalities and retinitis pigmentosa 59. Orthologous to human DHDDS (dehydrodolichyl diphosphate synthase subunit). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 153.0), Kidney (RPKM 90.8) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Dhdds in Genome Data Viewer
Location:
5q36
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (151482139..151508248, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (146198359..146224479, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (152200681..152227669, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L37A like 3 Neighboring gene high mobility group nucleosomal binding domain 2 Neighboring gene lin-28 homolog A Neighboring gene uncharacterized LOC134487000 Neighboring gene zinc finger protein 683

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. A conserved C-terminal RXG motif in the NgBR subunit of cis-prenyltransferase is critical for prenyltransferase activity. Grabińska KA, et al. J Biol Chem, 2017 Oct 20. PMID 28842490, Free PMC Article
  2. Mutation of Nogo-B receptor, a subunit of cis-prenyltransferase, causes a congenital disorder of glycosylation. Park EJ, et al. Cell Metab, 2014 Sep 2. PMID 25066056, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
contributes_to dehydrodolichyl diphosphate synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to dehydrodolichyl diphosphate synthase activity ISO
Inferred from Sequence Orthology
more info
  
enables dehydrodolichyl diphosphate synthase activity ISO
Inferred from Sequence Orthology
more info
  
contributes_to polyprenyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in dolichol biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in dolichyl diphosphate biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in polyprenol biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of dehydrodolichyl diphosphate synthase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of dehydrodolichyl diphosphate synthase complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
dehydrodolichyl diphosphate synthase complex subunit DHDDS
NP_001011978.1
XP_063143515.1
XP_063143516.1
XP_063143517.1
XP_063143518.1
XP_063143519.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001011978.1 → NP_001011978.1  dehydrodolichyl diphosphate synthase complex subunit DHDDS

    See identical proteins and their annotated locations for NP_001011978.1

    Status: PROVISIONAL

    Source sequence(s)
    BC085875
    UniProtKB/TrEMBL
    A0A8I6A4U9, F7FA94, Q5U2T2
    Related
    ENSRNOP00000087806.1, ENSRNOT00000118073.2
    Conserved Domains (1) summary
    cd00475
    Location:28 → 248
    Cis_IPPS; Cis (Z)-Isoprenyl Diphosphate Synthases

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    151482139..151508248 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063287449.1 → XP_063143519.1  dehydrodolichyl diphosphate synthase complex subunit DHDDS isoform X5

  2. XM_063287445.1 → XP_063143515.1  dehydrodolichyl diphosphate synthase complex subunit DHDDS isoform X1

    Related
    ENSRNOP00000020051.6, ENSRNOT00000020051.8

  3. XM_063287448.1 → XP_063143518.1  dehydrodolichyl diphosphate synthase complex subunit DHDDS isoform X4

  4. XM_063287446.1 → XP_063143516.1  dehydrodolichyl diphosphate synthase complex subunit DHDDS isoform X2

  5. XM_063287447.1 → XP_063143517.1  dehydrodolichyl diphosphate synthase complex subunit DHDDS isoform X3

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous