Mfsd2a MFSD2 lysolipid transporter A, lysophospholipid [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mfsd2aprovided by RGD
Official Full Name: MFSD2 lysolipid transporter A, lysophospholipidprovided by RGD
Primary source: RGD:1310174
See related: EnsemblRapid:ENSRNOG00000014008 AllianceGenome:RGD:1310174
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Mfsd2; RGD1310174
Summary: Predicted to enable lysophosphatidylcholine flippase activity; lysophospholipid:sodium symporter activity; and oleate transmembrane transporter activity. Predicted to be involved in several processes, including central nervous system development; lipid transport across blood-brain barrier; and lysophospholipid translocation. Predicted to act upstream of or within several processes, including photoreceptor cell development; regulation of lipid metabolic process; and retina development in camera-type eye. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 15. Orthologous to human MFSD2A (MFSD2 lysolipid transporter A, lysophospholipid). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Liver (RPKM 146.6), Brain (RPKM 50.1) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (140510933..140525828, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (135225801..135240744, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (140642865..140657759, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hypertension depresses but exercise training restores both Mfsd2a expression and blood-brain barrier function within PVN capillaries.
Title: Hypertension depresses but exercise training restores both Mfsd2a expression and blood-brain barrier function within PVN capillaries.
Porphyromonas gingivalis bacteremia increases the permeability of the blood-brain barrier via the Mfsd2a/Caveolin-1 mediated transcytosis pathway.
Title: Porphyromonas gingivalis bacteremia increases the permeability of the blood-brain barrier via the Mfsd2a/Caveolin-1 mediated transcytosis pathway.
Mfsd2a Attenuates Blood-Brain Barrier Disruption After Sub-arachnoid Hemorrhage by Inhibiting Caveolae-Mediated Transcellular Transport in Rats.
Title: Mfsd2a Attenuates Blood-Brain Barrier Disruption After Sub-arachnoid Hemorrhage by Inhibiting Caveolae-Mediated Transcellular Transport in Rats.

Submit: New GeneRIF Correction

General gene information

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Markers

BF387250 (e-PCR)
- UniSTS:244266

BF404032 (e-PCR)
- UniSTS:246866

BF400287 (e-PCR)
- UniSTS:244912

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables fatty acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables fatty acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables long-chain fatty acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables lysophosphatidylcholine flippase activity	ISO Inferred from Sequence Orthology more info
enables lysophospholipid:sodium symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables lysophospholipid:sodium symporter activity	ISO Inferred from Sequence Orthology more info
enables oleate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables symporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of brain development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within brain development	ISO Inferred from Sequence Orthology more info
involved_in carbohydrate transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to starvation	ISO Inferred from Sequence Orthology more info
acts_upstream_of cognition	ISO Inferred from Sequence Orthology more info
NOT involved_in embryonic brain development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within energy homeostasis	ISO Inferred from Sequence Orthology more info
NOT involved_in establishment of blood-brain barrier	ISO Inferred from Sequence Orthology more info
involved_in establishment of blood-brain barrier	ISO Inferred from Sequence Orthology more info
NOT involved_in establishment of blood-retinal barrier	ISO Inferred from Sequence Orthology more info
involved_in fatty acid transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid transport	ISO Inferred from Sequence Orthology more info
involved_in hippocampus development	ISO Inferred from Sequence Orthology more info
involved_in lipid transport across blood-brain barrier	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipid transport across blood-brain barrier	ISO Inferred from Sequence Orthology more info
involved_in long-chain fatty acid transport	ISO Inferred from Sequence Orthology more info
involved_in lysophospholipid translocation	IBA Inferred from Biological aspect of Ancestor more info
involved_in lysophospholipid translocation	ISO Inferred from Sequence Orthology more info
involved_in lysophospholipid transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within maintenance of blood-brain barrier	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within motor behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of fatty acid beta-oxidation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within photoreceptor cell morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within photoreceptor cell outer segment organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cell growth	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of triglyceride biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of regulation of dendrite development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of multicellular organism growth	ISO Inferred from Sequence Orthology more info
acts_upstream_of regulation of neuron projection arborization	ISO Inferred from Sequence Orthology more info
acts_upstream_of regulation of phosphatidylcholine metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of regulation of phosphatidylethanolamine metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of regulation of phosphatidylserine metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within retina morphogenesis in camera-type eye	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within retinal pigment epithelium development	ISO Inferred from Sequence Orthology more info
involved_in transcytosis	ISO Inferred from Sequence Orthology more info
involved_in transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within very-low-density lipoprotein particle assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: sodium-dependent lysophosphatidylcholine symporter 1

Names: major facilitator superfamily domain containing 2; major facilitator superfamily domain containing 2A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106683.1 → NP_001100153.1 sodium-dependent lysophosphatidylcholine symporter 1

See identical proteins and their annotated locations for NP_001100153.1

Status: PROVISIONAL

Source sequence(s)

CH473968

UniProtKB/TrEMBL

B1WBW6, F7F9H0

Conserved Domains (2) summary

pfam13347
Location:45 → 500

MFS_2; MFS/sugar transport protein

cl21472
Location:39 → 502

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

140510933..140525828 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039109607.2 → XP_038965535.1 sodium-dependent lysophosphatidylcholine symporter 1 isoform X2

Conserved Domains (1) summary

cl28910
Location:43 → 498

MFS; Major Facilitator Superfamily
XM_006238792.5 → XP_006238854.1 sodium-dependent lysophosphatidylcholine symporter 1 isoform X1

Related

ENSRNOP00000019080.5, ENSRNOT00000019080.9

Conserved Domains (2) summary

pfam13347
Location:44 → 499

MFS_2; MFS/sugar transport protein

cl21472
Location:38 → 501

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
XM_039109609.2 → XP_038965537.1 sodium-dependent lysophosphatidylcholine symporter 1 isoform X3

Conserved Domains (1) summary

cl28910
Location:45 → 212

MFS; Major Facilitator Superfamily