U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Ipp intracisternal A particle-promoted polypeptide [ Rattus norvegicus (Norway rat) ]

Gene ID: 298439, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
Ippprovided by RGD
Official Full Name
intracisternal A particle-promoted polypeptideprovided by RGD
Primary source
RGD:1306299
See related
EnsemblRapid:ENSRNOG00000016183 AllianceGenome:RGD:1306299
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human IPP (intracisternal A particle-promoted polypeptide). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Kidney (RPKM 167.4), Spleen (RPKM 98.8) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Ipp in Genome Data Viewer
Location:
5q35
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (135199198..135237912)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (129962528..130001237)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (135351767..135390363)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene microtubule associated serine/threonine kinase 2 Neighboring gene U6 spliceosomal RNA Neighboring gene U6 spliceosomal RNA Neighboring gene ribosomal protein L7a, pseudogene 20 Neighboring gene GC-rich promoter binding protein 1-like 1 Neighboring gene transmembrane protein 69 Neighboring gene coiled-coil domain containing 17

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin-like ligase-substrate adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of Cul3-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
actin-binding protein IPP
Names
IAP promoted placental

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106679.2 → NP_001100149.2  actin-binding protein IPP

    See identical proteins and their annotated locations for NP_001100149.2

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A0A8I6ACD3, D4A1F4
    Related
    ENSRNOP00000112517.1, ENSRNOT00000148029.1
    Conserved Domains (3) summary
    PHA03098
    Location:34 → 575
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:333 → 376
    Kelch; KELCH repeat [structural motif]
    cd18256
    Location:17 → 141
    BTB_POZ_KLHL27_IPP; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    135199198..135237912
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063287406.1 → XP_063143476.1  actin-binding protein IPP isoform X4

  2. XM_063287405.1 → XP_063143475.1  actin-binding protein IPP isoform X3

    UniProtKB/TrEMBL
    A0A0G2JYR6

  3. XM_006238640.5 → XP_006238702.1  actin-binding protein IPP isoform X1

    See identical proteins and their annotated locations for XP_006238702.1

    UniProtKB/TrEMBL
    A0A8I6ACD3, D4A1F4
    Conserved Domains (3) summary
    PHA03098
    Location:34 → 575
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:333 → 376
    Kelch; KELCH repeat [structural motif]
    cd18256
    Location:17 → 141
    BTB_POZ_KLHL27_IPP; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP)

  4. XM_006238643.5 → XP_006238705.1  actin-binding protein IPP isoform X2

    UniProtKB/TrEMBL
    A0A8I6G2C9
    Related
    ENSRNOP00000078800.2, ENSRNOT00000106880.2
    Conserved Domains (4) summary
    PHA03098
    Location:34 → 540
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:333 → 376
    Kelch; KELCH repeat [structural motif]
    cd18256
    Location:17 → 141
    BTB_POZ_KLHL27_IPP; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP)
    cd18466
    Location:134 → 236
    BACK_KLHL27_IPP; BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide (IPP)

  5. XM_006238644.5 → XP_006238706.1  actin-binding protein IPP isoform X3

    UniProtKB/TrEMBL
    A0A0G2JYR6
    Conserved Domains (5) summary
    smart00612
    Location:486 → 533
    Kelch; Kelch domain
    PHA03098
    Location:34 → 540
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:333 → 376
    Kelch; KELCH repeat [structural motif]
    pfam00651
    Location:27 → 131
    BTB; BTB/POZ domain
    pfam07707
    Location:139 → 241
    BACK; BTB And C-terminal Kelch

  6. XM_006238642.5 → XP_006238704.1  actin-binding protein IPP isoform X1

    See identical proteins and their annotated locations for XP_006238704.1

    UniProtKB/TrEMBL
    A0A8I6ACD3, D4A1F4
    Related
    ENSRNOP00000021850.5, ENSRNOT00000021850.7
    Conserved Domains (3) summary
    PHA03098
    Location:34 → 575
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:333 → 376
    Kelch; KELCH repeat [structural motif]
    cd18256
    Location:17 → 141
    BTB_POZ_KLHL27_IPP; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP)

  7. XM_039109597.2 → XP_038965525.1  actin-binding protein IPP isoform X2

    UniProtKB/TrEMBL
    A0A8I6G2C9
    Conserved Domains (4) summary
    PHA03098
    Location:34 → 540
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:333 → 376
    Kelch; KELCH repeat [structural motif]
    cd18256
    Location:17 → 141
    BTB_POZ_KLHL27_IPP; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP)
    cd18466
    Location:134 → 236
    BACK_KLHL27_IPP; BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide (IPP)

  8. XM_039109598.2 → XP_038965526.1  actin-binding protein IPP isoform X4

    Conserved Domains (4) summary
    smart00612
    Location:392 → 437
    Kelch; Kelch domain
    sd00038
    Location:333 → 377
    Kelch; KELCH repeat [structural motif]
    cd18256
    Location:17 → 141
    BTB_POZ_KLHL27_IPP; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP)
    cd18466
    Location:134 → 236
    BACK_KLHL27_IPP; BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide (IPP)

  9. XM_063287404.1 → XP_063143474.1  actin-binding protein IPP isoform X1

    UniProtKB/TrEMBL
    A0A8I6ACD3, D4A1F4
    Related
    ENSRNOP00000070763.3, ENSRNOT00000082602.3

  10. XM_017593275.3 → XP_017448764.1  actin-binding protein IPP isoform X1

    UniProtKB/TrEMBL
    A0A8I6ACD3, D4A1F4
    Conserved Domains (3) summary
    PHA03098
    Location:34 → 575
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:333 → 376
    Kelch; KELCH repeat [structural motif]
    cd18256
    Location:17 → 141
    BTB_POZ_KLHL27_IPP; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP)

RNA

  1. XR_010066362.1 RNA Sequence

  2. XR_005504404.2 RNA Sequence

  3. XR_005504405.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools