Slc35d1 solute carrier family 35 member D1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc35d1provided by RGD
Official Full Name: solute carrier family 35 member D1provided by RGD
Primary source: RGD:1309843
See related: EnsemblRapid:ENSRNOG00000022967 AllianceGenome:RGD:1309843
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable antiporter activity and pyrimidine nucleotide-sugar transmembrane transporter activity. Predicted to be involved in nucleotide-sugar transmembrane transport. Predicted to act upstream of or within chondroitin sulfate biosynthetic process; embryonic skeletal system development; and pyrimidine nucleotide-sugar transmembrane transport. Predicted to be located in endoplasmic reticulum. Predicted to be active in Golgi apparatus. Human ortholog(s) of this gene implicated in schneckenbecken dysplasia. Orthologous to human SLC35D1 (solute carrier family 35 member D1). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Kidney (RPKM 43.3), Spleen (RPKM 25.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q33

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (123157739..123210350, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (117928628..117981289, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (122700396..122746815, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH132024 (e-PCR)
- UniSTS:215307

NoName (e-PCR)
- UniSTS:547090

Slc35d1 (e-PCR), detects polymorphism
- UniSTS:547090

UniSTS:502442 (e-PCR)
- UniSTS:502442

BE113550 (e-PCR)
- UniSTS:246703

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables UDP-N-acetylgalactosamine transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables UDP-N-acetylglucosamine transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables UDP-glucuronic acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables antiporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables antiporter activity	ISO Inferred from Sequence Orthology more info
enables pyrimidine nucleotide-sugar transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in UDP-N-acetylgalactosamine transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in UDP-N-acetylglucosamine transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in UDP-glucuronic acid transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chondroitin sulfate biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic skeletal system development	ISO Inferred from Sequence Orthology more info
involved_in nucleotide-sugar transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within pyrimidine nucleotide-sugar transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in pyrimidine nucleotide-sugar transmembrane transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: nucleotide sugar transporter SLC35D1

Names: UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter; solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1; solute carrier family 35 (UDP-glucuronic acid/UDP-N-acetylgalactosamine dual transporter), member D1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106668.2 → NP_001100138.1 nucleotide sugar transporter SLC35D1

See identical proteins and their annotated locations for NP_001100138.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/TrEMBL

A6JRS5, D3ZVG2

Related

ENSRNOP00000079911.1, ENSRNOT00000094233.2

Conserved Domains (1) summary

COG5070
Location:19 → 299

VRG4; Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

123157739..123210350 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039109539.2 → XP_038965467.1 nucleotide sugar transporter SLC35D1 isoform X1

UniProtKB/TrEMBL

A0A8I5ZPC4

Conserved Domains (1) summary

COG5070
Location:49 → 327

VRG4; Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]