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Plin2 perilipin 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 298199, updated on 27-Nov-2024

Summary

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Official Symbol
Plin2provided by RGD
Official Full Name
perilipin 2provided by RGD
Primary source
RGD:728889
See related
EnsemblRapid:ENSRNOG00000007060 AllianceGenome:RGD:728889
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Adfp; Adrp
Summary
Involved in response to organic cyclic compound and response to xenobiotic stimulus. Located in lipid droplet. Orthologous to human PLIN2 (perilipin 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Liver (RPKM 987.2), Adrenal (RPKM 733.7) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Plin2 in Genome Data Viewer
Location:
5q32
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (106202634..106258748, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (101156648..101211738, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (104984413..105010863, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene Ras-related GTP binding A Neighboring gene HAUS augmin like complex subunit 6 Neighboring gene small Cajal body-specific RNA 8 Neighboring gene uncharacterized LOC102547623 Neighboring gene uncharacterized LOC134486947 Neighboring gene DENN domain containing 4C

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Induction of the adipose differentiation-related protein in liver of etomoxir-treated rats. Steiner S, et al. Biochem Biophys Res Commun, 1996 Jan 26. PMID 8579590
  2. New insight into the mechanisms of ectopic fat deposition improvement after bariatric surgery. Angelini G, et al. Sci Rep, 2019 Nov 21. PMID 31754142, Free PMC Article
  3. Palmitate mediated diacylglycerol accumulation causes endoplasmic reticulum stress, Plin2 degradation, and cell death in H9C2 cardiomyoblasts. Akoumi A, et al. Exp Cell Res, 2017 May 15. PMID 28336294
  4. Evidence for decreased lipofibroblast expression in hypoplastic rat lungs with congenital diaphragmatic hernia. Friedmacher F, et al. Pediatr Surg Int, 2014 Oct. PMID 25023943
  5. Prenatal retinoic acid increases lipofibroblast expression in hypoplastic rat lungs with experimental congenital diaphragmatic hernia. Friedmacher F, et al. J Pediatr Surg, 2014 Jun. PMID 24888826

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TRIM21-mediated ubiquitination of PLIN2 regulates neuronal lipid droplet accumulation after acute spinal cord injury.
    Title: TRIM21-mediated ubiquitination of PLIN2 regulates neuronal lipid droplet accumulation after acute spinal cord injury.
  2. Inhibition of perilipin 2 attenuates cerebral ischemia/reperfusion injury by blocking NLRP3 inflammasome activation both in vivo and in vitro.
    Title: Inhibition of perilipin 2 attenuates cerebral ischemia/reperfusion injury by blocking NLRP3 inflammasome activation both in vivo and in vitro.
  3. Perilipin 2 downregulation in beta cells impairs insulin secretion under nutritional stress and damages mitochondria.
    Title: Perilipin 2 downregulation in β cells impairs insulin secretion under nutritional stress and damages mitochondria.
  4. New insight into the mechanisms of ectopic fat deposition improvement after bariatric surgery.
    Title: New insight into the mechanisms of ectopic fat deposition improvement after bariatric surgery.
  5. Endoplasmic reticulum stress induced by either palmitate, tunicamycin, or thapsigargin led to the degradation of Plin2, an important lipid droplet binding protein.
    Title: Palmitate mediated diacylglycerol accumulation causes endoplasmic reticulum stress, Plin2 degradation, and cell death in H9C2 cardiomyoblasts.
  6. It has been demonstrated that ADRP is critically important during fetal lung maturation as it regulates the alveolar lipid homeostasis.
    Title: Evidence for decreased lipofibroblast expression in hypoplastic rat lungs with congenital diaphragmatic hernia.
  7. Increased LIF expression after prenatal treatment with ATRA in nitrofen-induced PH suggests that ATRA may have a therapeutic potential in attenuating CDH-associated PH by stimulating alveolar development.
    Title: Prenatal retinoic acid increases lipofibroblast expression in hypoplastic rat lungs with experimental congenital diaphragmatic hernia.
  8. This study demonstrates, for the first time, the presence of OXPAT and TIP47 transcripts in rat hepatocytes, as well as their up-regulation with lipid accumulation.
    Title: PAT protein mRNA expression in primary rat hepatocytes: Effects of exposure to fatty acids.
  9. Results indicate involvement of OXPAT and ADRP in muscular lipid accumulation and type 2 diabetes.
    Title: Adipocyte differentiation-related protein and OXPAT in rat and human skeletal muscle: involvement in lipid accumulation and type 2 diabetes mellitus.
  10. In steatotic hepatocytes ADRP selectively stains the surface of macrovesicular and microvesicular lipid droplets.
    Title: Adipose differentiation-related protein is a reliable lipid droplet marker in alcoholic fatty liver of rats.
Submit: New GeneRIF Correction See all GeneRIFs (13)

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC94591

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in cellular response to glucose starvation ISO
Inferred from Sequence Orthology
more info
  
involved_in lipid droplet disassembly ISO
Inferred from Sequence Orthology
more info
  
involved_in lipid storage IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within lipid storage ISO
Inferred from Sequence Orthology
more info
  
involved_in lipid storage ISO
Inferred from Sequence Orthology
more info
  
involved_in lipid storage TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within long-chain fatty acid transport ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of sequestering of triglyceride IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in lipid droplet IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lipid droplet IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lipid droplet ISO
Inferred from Sequence Orthology
more info
  
located_in lipid droplet TAS
Traceable Author Statement
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
perilipin-2
Names
adipose differentiation related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007144.3 → NP_001007145.1  perilipin-2 isoform 1

    See identical proteins and their annotated locations for NP_001007145.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A6J875, Q5U2U5
    Conserved Domains (1) summary
    pfam03036
    Location:5 → 404
    Perilipin; Perilipin family

  2. NM_001399043.2 → NP_001385972.1  perilipin-2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A0A8I5ZQJ5
    Conserved Domains (1) summary
    pfam03036
    Location:5 → 402
    Perilipin; Perilipin family

  3. NM_001400551.1 → NP_001387480.1  perilipin-2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    Q5U2U5

  4. NM_001400552.1 → NP_001387481.1  perilipin-2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A0A8I5ZQJ5
    Related
    ENSRNOP00000079287.1, ENSRNOT00000115133.2

  5. NM_001400553.1 → NP_001387482.1  perilipin-2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    Conserved Domains (1) summary
    pfam03036
    Location:5 → 398
    Perilipin; Perilipin family

  6. NM_001400554.1 → NP_001387483.1  perilipin-2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005

  7. NM_001400555.1 → NP_001387484.1  perilipin-2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    Related
    ENSRNOP00000093929.1, ENSRNOT00000105644.2

  8. NM_001400556.1 → NP_001387485.1  perilipin-2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    106202634..106258748 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039109519.2 → XP_038965447.2  perilipin-2 isoform X2

    Related
    ENSRNOP00000093118.2, ENSRNOT00000097668.2

  2. XM_063287370.1 → XP_063143440.1  perilipin-2 isoform X7

  3. XM_063287369.1 → XP_063143439.1  perilipin-2 isoform X6

  4. XM_063287367.1 → XP_063143437.1  perilipin-2 isoform X4

    UniProtKB/TrEMBL
    A0A8I5ZQJ5

  5. XM_039109518.2 → XP_038965446.2  perilipin-2 isoform X1

  6. XM_063287368.1 → XP_063143438.1  perilipin-2 isoform X5

    Related
    ENSRNOP00000104576.1, ENSRNOT00000135688.1

  7. XM_039109521.2 → XP_038965449.1  perilipin-2 isoform X3

    UniProtKB/TrEMBL
    A6J875, Q5U2U5
    Conserved Domains (1) summary
    pfam03036
    Location:5 → 404
    Perilipin; Perilipin family
Nucleotide Protein Strain
Heading Accession and Version

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