U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Trmo tRNA methyltransferase O [ Rattus norvegicus (Norway rat) ]

Gene ID: 298072, updated on 27-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Trmoprovided by RGD
Official Full Name
tRNA methyltransferase Oprovided by RGD
Primary source
RGD:1305420
See related
EnsemblRapid:ENSRNOG00000009492 AllianceGenome:RGD:1305420
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Nap1; RGD1305420
Summary
Predicted to enable tRNA (L-threonylcarbamoyladenosine(37)-C2) methyltransferase activity. Predicted to be involved in tRNA methylation. Orthologous to human TRMO (tRNA methyltransferase O). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 49.8), Adrenal (RPKM 27.3) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Trmo in Genome Data Viewer
Location:
5q22
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (65461489..65472019, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (60663106..60676423, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (61992507..62001065, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene sorbitol dehydrogenase, pseudogene 4 Neighboring gene forkhead box E1 Neighboring gene uncharacterized LOC120102868 Neighboring gene hemogen Neighboring gene prefoldin subunit 6, pseudogene 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Discovery of the β-barrel-type RNA methyltransferase responsible for N6-methylation of N6-threonylcarbamoyladenosine in tRNAs. Kimura S, et al. Nucleic Acids Res, 2014 Aug. PMID 25063302, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC116115

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables tRNA (L-threonylcarbamoyladenosine(37)-C2) methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables tRNA (L-threonylcarbamoyladenosine(37)-C2) methyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in tRNA methylation ISO
Inferred from Sequence Orthology
more info
  
involved_in tRNA methylation ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

Go to the top of the page Help
Preferred Names
tRNA (adenine(37)-N6)-methyltransferase
Names
nef-associated protein 1
thioesterase NAP1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025652.1 → NP_001020823.1  tRNA (adenine(37)-N6)-methyltransferase

    See identical proteins and their annotated locations for NP_001020823.1

    Status: PROVISIONAL

    Source sequence(s)
    BC097981
    UniProtKB/Swiss-Prot
    Q4V7E0
    UniProtKB/TrEMBL
    A6IJB6, A6IJB7
    Related
    ENSRNOP00000012602.6, ENSRNOT00000012602.9
    Conserved Domains (2) summary
    pfam01980
    Location:45 → 164
    UPF0066; Uncharacterized protein family UPF0066
    pfam18389
    Location:325 → 387
    TrmO_C; TrmO C-terminal domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    65461489..65472019 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039109455.2 → XP_038965383.1  tRNA (adenine(37)-N6)-methyltransferase isoform X2

    UniProtKB/TrEMBL
    A6IJB6
    Conserved Domains (2) summary
    pfam01980
    Location:2 → 90
    UPF0066; Uncharacterized protein family UPF0066
    pfam18389
    Location:251 → 313
    TrmO_C; TrmO C-terminal domain

  2. XM_039109454.2 → XP_038965382.1  tRNA (adenine(37)-N6)-methyltransferase isoform X1

    UniProtKB/TrEMBL
    A6IJB6
    Related
    ENSRNOP00000110752.1, ENSRNOT00000147188.1
    Conserved Domains (2) summary
    pfam01980
    Location:56 → 175
    UPF0066; Uncharacterized protein family UPF0066
    pfam18389
    Location:336 → 398
    TrmO_C; TrmO C-terminal domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4V7E0.1 GenPept UniProtKB/Swiss-Prot:Q4V7E0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools