Nudt2 nudix hydrolase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nudt2provided by RGD
Official Full Name: nudix hydrolase 2provided by RGD
Primary source: RGD:1303023
See related: AllianceGenome:RGD:1303023
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity. Predicted to be involved in AMP biosynthetic process and ATP biosynthetic process. Orthologous to human NUDT2 (nudix hydrolase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 194.3), Muscle (RPKM 172.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q22

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (61424176..61439018)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (56628265..56643104)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (57845819..57860658)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

evidence provided that Ap(4)A hydrolase is responsible for Ap(4)A degradation following immunologic activation of mast cells; observations show involvement of Ap(4)A hydrolase in gene regulation can also occur in activated cardiac cells.
Title: Diadenosine tetraphosphate hydrolase is part of the transcriptional regulation network in immunologically activated mast cells.

Submit: New GeneRIF Correction

General gene information

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Markers

BF284944 (e-PCR)
- UniSTS:261419

RH136690 (e-PCR)
- UniSTS:218779

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity	IBA Inferred from Biological aspect of Ancestor more info
enables bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity	ISO Inferred from Sequence Orthology more info
enables bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity	ISS Inferred from Sequence or Structural Similarity more info
enables hydrolase activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in AMP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ATP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]

Names: ap4A hydrolase; ap4Aase; bis(5'-nucleosyl)-tetraphosphatase; diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical hydrolase; diadenosine tetraphosphatase; nucleoside diphosphate-linked moiety X motif 2; nudix (nucleoside diphosphate linked moiety X)-type motif 2; nudix motif 2

NP_997479.1

EC 3.6.1.17

XP_063143372.1

EC 3.6.1.17

XP_063143373.1

EC 3.6.1.17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_207596.2 → NP_997479.1 bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]

See identical proteins and their annotated locations for NP_997479.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

Q6PEC0

UniProtKB/TrEMBL

A6IIV0

Conserved Domains (1) summary

cd03428
Location:2 → 140

Ap4A_hydrolase_human_like; Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

61424176..61439018

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063287303.1 → XP_063143373.1 bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] isoform X1

UniProtKB/Swiss-Prot

Q6PEC0

UniProtKB/TrEMBL

A6IIV0
XM_063287302.1 → XP_063143372.1 bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] isoform X1

UniProtKB/Swiss-Prot

Q6PEC0

UniProtKB/TrEMBL

A6IIV0