Gem GTP binding protein overexpressed in skeletal muscle [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gemprovided by RGD
Official Full Name: GTP binding protein overexpressed in skeletal muscleprovided by RGD
Primary source: RGD:1307386
See related: EnsemblRapid:ENSRNOG00000015160 AllianceGenome:RGD:1307386
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including calcium channel regulator activity; guanyl ribonucleotide binding activity; and magnesium ion binding activity. Predicted to be involved in chromosome organization; metaphase chromosome alignment; and mitotic cell cycle. Predicted to be located in several cellular components, including cytoplasmic side of plasma membrane; midbody; and spindle. Predicted to be active in plasma membrane. Biomarker of glaucoma. Orthologous to human GEM (GTP binding protein overexpressed in skeletal muscle). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Adrenal (RPKM 126.4), Uterus (RPKM 117.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q13

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (30011641..30022554)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (25214309..25225222)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (25339479..25353661)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest that GTP-binding protein Gem might play a crucial role in retinal ganglion cells (RGCs) apoptosis after nerve crush (ONC).
Title: Upregulation of Gem relates to retinal ganglion cells apoptosis after optic nerve crush in adult rats.
The results of tjis study suggested that Gem may be implicated in the proliferation of microglia and astrocytes after spinal cord injury.
Title: Spatiotemporal patterns of Gem expression after rat spinal cord injury.
Increased expression of Gem after rat sciatic nerve injury.
Title: Increased expression of Gem after rat sciatic nerve injury.
binding of 14-3-3, calmodulin and calcium channel beta-subunits to Kir/Gem is mutually exclusive
Title: 14-3-3 and calmodulin control subcellular distribution of Kir/Gem and its regulation of cell shape and calcium channel activity.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GDP binding	ISO Inferred from Sequence Orthology more info
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	ISO Inferred from Sequence Orthology more info
enables GTPase activity	ISO Inferred from Sequence Orthology more info
enables calcium channel regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in chromosome organization	ISO Inferred from Sequence Orthology more info
involved_in metaphase chromosome alignment	ISO Inferred from Sequence Orthology more info
involved_in mitotic cell cycle	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasmic side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in midbody	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info
located_in spindle midzone	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: GTP-binding protein GEM

Names: GTP binding protein (gene overexpressed in skeletal muscle)

NP_001100107.1

EC 3.6.5.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106637.1 → NP_001100107.1 GTP-binding protein GEM

See identical proteins and their annotated locations for NP_001100107.1

Status: PROVISIONAL

Source sequence(s)

CH473962

UniProtKB/TrEMBL

A0A9K3Y811, B5DFA6, E9PT99

Related

ENSRNOP00000020826.6, ENSRNOT00000020826.7

Conserved Domains (2) summary

smart00010
Location:75 → 241

small_GTPase; Small GTPase of the Ras superfamily; ill-defined subfamily

cd04148
Location:75 → 295

RGK; Rem, Rem2, Rad, Gem/Kir (RGK) subfamily of Ras GTPases