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Ltbr lymphotoxin beta receptor [ Rattus norvegicus (Norway rat) ]

Gene ID: 297604, updated on 4-Jan-2025

Summary

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Official Symbol
Ltbrprovided by RGD
Official Full Name
lymphotoxin beta receptorprovided by RGD
Primary source
RGD:1309448
See related
EnsemblRapid:ENSRNOG00000019264 AllianceGenome:RGD:1309448
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable identical protein binding activity and ubiquitin protein ligase binding activity. Predicted to be involved in cellular response to mechanical stimulus and positive regulation of signal transduction. Predicted to act upstream of or within myeloid dendritic cell differentiation. Predicted to be located in Golgi apparatus. Orthologous to human LTBR (lymphotoxin beta receptor). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Liver (RPKM 279.1), Lung (RPKM 262.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ltbr in Genome Data Viewer
Location:
4q42
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (159795115..159801571, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (158108884..158115339, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (157822838..157829291, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA70 Neighboring gene uncharacterized LOC102555545 Neighboring gene tubulin, alpha 3A Neighboring gene sodium channel epithelial 1 subunit alpha Neighboring gene TNF receptor superfamily member 1A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The MYND domain-containing protein BRAM1 inhibits lymphotoxin beta receptor-mediated signaling through affecting receptor oligomerization. Liu HP, et al. Cell Signal, 2011 Jan. PMID 20732415
  2. Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens. Satpathy AT, et al. Nat Immunol, 2013 Sep. PMID 23913046, Free PMC Article
  3. A diverse family of proteins containing tumor necrosis factor receptor-associated factor domains. Zapata JM, et al. J Biol Chem, 2001 Jun 29. PMID 11279055
  4. Expression of the Bcl-2 protein BAD promotes prostate cancer growth. Smith AJ, et al. PLoS One, 2009 Jul 13. PMID 19593445, Free PMC Article
  5. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. Matsuda A, et al. Oncogene, 2003 May 22. PMID 12761501

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC94657

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cellular response to mechanical stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in hematopoietic or lymphoid organ development IEA
Inferred from Electronic Annotation
more info
  
involved_in immune response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within myeloid dendritic cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of canonical NF-kappaB signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
tumor necrosis factor receptor superfamily member 3
Names
lymphotoxin B receptor
lymphotoxin beta receptor (TNFR superfamily, member 3)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008315.1 → NP_001008316.1  tumor necrosis factor receptor superfamily member 3 precursor

    See identical proteins and their annotated locations for NP_001008316.1

    Status: PROVISIONAL

    Source sequence(s)
    BC085880
    UniProtKB/TrEMBL
    F7FAR8, Q5U2S8
    Related
    ENSRNOP00000026184.5, ENSRNOT00000026184.6
    Conserved Domains (3) summary
    cd00185
    Location:172 → 212
    TNFRSF; CRD2 [structural motif]
    cd10578
    Location:11 → 170
    TNFRSF3; Tumor necrosis factor receptor superfamily member 3 (TNFRSF3), also known as lymphotoxin beta receptor (LTBR)
    cl22855
    Location:148 → 212
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    159795115..159801571 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006237351.2 → XP_006237413.1  tumor necrosis factor receptor superfamily member 3 isoform X1

    UniProtKB/TrEMBL
    F7FAR8
    Conserved Domains (3) summary
    cd00185
    Location:172 → 212
    TNFRSF; CRD2 [structural motif]
    cd10578
    Location:11 → 170
    TNFRSF3; Tumor necrosis factor receptor superfamily member 3 (TNFRSF3), also known as lymphotoxin beta receptor (LTBR)
    cl22855
    Location:148 → 212
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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