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Kcnab2 potassium voltage-gated channel subfamily A regulatory beta subunit 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29738, updated on 27-Nov-2024

Summary

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Official Symbol
Kcnab2provided by RGD
Official Full Name
potassium voltage-gated channel subfamily A regulatory beta subunit 2provided by RGD
Primary source
RGD:61828
See related
EnsemblRapid:ENSRNOG00000011550 AllianceGenome:RGD:61828
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables aldo-keto reductase (NADPH) activity; potassium channel regulator activity; and transmembrane transporter binding activity. Involved in several processes, including NADPH oxidation; myoblast differentiation; and regulation of protein localization to cell surface. Located in several cellular components, including axon; cytoplasmic side of plasma membrane; and microtubule. Part of potassium channel complex. Is active in glutamatergic synapse and postsynaptic density membrane. Orthologous to human KCNAB2 (potassium voltage-gated channel subfamily A regulatory beta subunit 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 249.8), Thymus (RPKM 121.4) and 3 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Kcnab2 in Genome Data Viewer
Location:
5q36
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (168182228..168270760, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (162899511..162988057, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (169570327..169658875, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120103139 Neighboring gene ribosomal protein L22 Neighboring gene chromodomain helicase DNA binding protein 5 Neighboring gene small ribosomal subunit protein eS27-like Neighboring gene nephrocystin 4 Neighboring gene uncharacterized LOC134479049 Neighboring gene uncharacterized LOC102549399

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. New inhibitors of the Kvβ2 subunit from mammalian Kv1 potassium channels. Alka K, et al. Int J Biochem Cell Biol, 2014 Oct. PMID 25066316
  2. A defined heteromeric KV1 channel stabilizes the intrinsic pacemaking and regulates the output of deep cerebellar nuclear neurons to thalamic targets. Ovsepian SV, et al. J Physiol, 2013 Apr 1. PMID 23318870, Free PMC Article
  3. Separable effects of human Kvbeta1.2 N- and C-termini on inactivation and expression of human Kv1.4. Accili EA, et al. J Physiol, 1998 Oct 15. PMID 9763623, Free PMC Article
  4. Catalytic reduction of carbonyl groups in oxidized PAPC by Kvβ2 (AKR6). Xie Z, et al. Chem Biol Interact, 2011 May 30. PMID 21296056, Free PMC Article
  5. Catalytic mechanism and substrate specificity of the beta-subunit of the voltage-gated potassium channel. Tipparaju SM, et al. Biochemistry, 2008 Aug 26. PMID 18672894, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data suggest that potassium channel Kvbeta2 inhibitors could serve as tools to decipher the role of Kvbeta2 in vivo and, eventually, inform the development of novel therapeutics.
    Title: New inhibitors of the Kvβ2 subunit from mammalian Kv1 potassium channels.
  2. Article reports a newly identified protein-protein interaction between the PSD-protein ProSAP2/Shank3 and the voltage-gated potassium channel subunit Kvbeta2
    Title: The Kvβ2 subunit of voltage-gated potassium channels is interacting with ProSAP2/Shank3 in the PSD.
  3. Kvbeta2 catalyzed the NADPH-dependent reduction of several products of oxPAPC
    Title: Catalytic reduction of carbonyl groups in oxidized PAPC by Kvβ2 (AKR6).
  4. ZIP3 formed dimers with ZIP1-3 and interacted with PKC-zeta and the shaker-type potassium channel subunit Kv beta 2
    Title: ZIP3, a new splice variant of the PKC-zeta-interacting protein family, binds to GABAC receptors, PKC-zeta, and Kv beta 2.
  5. identification of Kvbeta2 substrates and the demonstration that Kvbeta2 is a functional aldo-keto reductase
    Title: Modulation of voltage-dependent Shaker family potassium channels by an aldo-keto reductase.
  6. There is a possibility that the K+ voltage-gated channel function is modulated by its beta-subunit.
    Title: Conformational changes in the C terminus of Shaker K+ channel bound to the rat Kvbeta2-subunit.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables aldo-keto reductase (NADPH) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aldo-keto reductase (NADPH) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables methylglyoxal reductase (NADPH) (acetol producing) activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables potassium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables potassium channel regulator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables potassium channel regulator activity IEA
Inferred from Electronic Annotation
more info
  
enables potassium channel regulator activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transmembrane transporter binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables voltage-gated potassium channel activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in NADPH oxidation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within hematopoietic progenitor cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in myoblast differentiation IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in neuromuscular process ISO
Inferred from Sequence Orthology
more info
  
involved_in potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of potassium ion transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein localization to cell surface IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
located_in axon IEA
Inferred from Electronic Annotation
more info
  
located_in axon ISO
Inferred from Sequence Orthology
more info
  
is_active_in axon initial segment ISO
Inferred from Sequence Orthology
more info
  
located_in axon terminus ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in juxtaparanode region of axon IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in juxtaparanode region of axon IDA
Inferred from Direct Assay
more info
 PubMed 
located_in juxtaparanode region of axon IEA
Inferred from Electronic Annotation
more info
  
located_in juxtaparanode region of axon ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in neuron projection IDA
Inferred from Direct Assay
more info
 PubMed 
located_in pinceau fiber IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic density membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic density membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
part_of potassium channel complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
  
part_of voltage-gated potassium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of voltage-gated potassium channel complex IEA
Inferred from Electronic Annotation
more info
  
part_of voltage-gated potassium channel complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
voltage-gated potassium channel subunit beta-2
Names
K(+) channel subunit beta-2
kv-beta-2
potassium channel, voltage gated shaker-related subfamily A regulatory beta subunit 2
potassium channel, voltage gated subfamily A regulatory beta subunit 2
potassium voltage-gated channel, shaker-related subfamily, beta member 2
NP_059000.1
XP_017448703.1
XP_017448704.1
XP_038965314.1
XP_063143337.1
XP_063143338.1
XP_063143339.1
XP_063143340.1
XP_063143341.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001429742.1 → NP_001416671.1  voltage-gated potassium channel subunit beta-2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005

  2. NM_001429743.1 → NP_001416672.1  voltage-gated potassium channel subunit beta-2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005

  3. NM_001429744.1 → NP_001416673.1  voltage-gated potassium channel subunit beta-2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A0A8L2Q7L3

  4. NM_001429745.1 → NP_001416674.1  voltage-gated potassium channel subunit beta-2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005

  5. NM_001429746.1 → NP_001416675.1  voltage-gated potassium channel subunit beta-2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/Swiss-Prot
    P62483
    UniProtKB/TrEMBL
    A6IUI6

  6. NM_001429747.1 → NP_001416676.1  voltage-gated potassium channel subunit beta-2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A0A8I6GCY0

  7. NM_001429748.1 → NP_001416677.1  voltage-gated potassium channel subunit beta-2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A0A8I6GCY0

  8. NM_017304.3 → NP_059000.1  voltage-gated potassium channel subunit beta-2 isoform 5

    See identical proteins and their annotated locations for NP_059000.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/Swiss-Prot
    P62483
    UniProtKB/TrEMBL
    A0A8I5ZVX6, A6IUI6
    Related
    ENSRNOP00000085478.2, ENSRNOT00000101700.2
    Conserved Domains (1) summary
    cd19141
    Location:38 → 347
    Aldo_ket_red_shaker; Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    168182228..168270760 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017593214.3 → XP_017448703.1  voltage-gated potassium channel subunit beta-2 isoform X1

    Related
    ENSRNOP00000015840.3, ENSRNOT00000015840.5
    Conserved Domains (1) summary
    cd19141
    Location:38 → 363
    Aldo_ket_red_shaker; Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR)

  2. XM_039109386.2 → XP_038965314.1  voltage-gated potassium channel subunit beta-2 isoform X6

    UniProtKB/TrEMBL
    A0A8I5ZVX6
    Conserved Domains (1) summary
    cl00470
    Location:1 → 296
    AKR_SF; Aldo-keto reductase (AKR) superfamily

  3. XM_063287270.1 → XP_063143340.1  voltage-gated potassium channel subunit beta-2 isoform X5

    Related
    ENSRNOP00000082892.2, ENSRNOT00000111948.2

  4. XM_063287268.1 → XP_063143338.1  voltage-gated potassium channel subunit beta-2 isoform X3

    Related
    ENSRNOP00000081886.1, ENSRNOT00000113173.2

  5. XM_063287269.1 → XP_063143339.1  voltage-gated potassium channel subunit beta-2 isoform X4

  6. XM_063287267.1 → XP_063143337.1  voltage-gated potassium channel subunit beta-2 isoform X2

  7. XM_017593215.3 → XP_017448704.1  voltage-gated potassium channel subunit beta-2 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZVX6, A0A8L2Q7L3
    Conserved Domains (1) summary
    cd19141
    Location:38 → 363
    Aldo_ket_red_shaker; Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR)

  8. XM_063287271.1 → XP_063143341.1  voltage-gated potassium channel subunit beta-2 isoform X7

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P62483.1 GenPept UniProtKB/Swiss-Prot:P62483

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