Ctnna2 catenin alpha 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ctnna2provided by RGD
Official Full Name: catenin alpha 2provided by RGD
Primary source: RGD:1305060
See related: EnsemblRapid:ENSRNOG00000006003 AllianceGenome:RGD:1305060
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Catna2
Summary: Predicted to enable actin filament binding activity and identical protein binding activity. Predicted to be involved in several processes, including modification of postsynaptic actin cytoskeleton; negative regulation of Arp2/3 complex-mediated actin nucleation; and nervous system development. Predicted to be located in several cellular components, including adherens junction; basolateral plasma membrane; and postsynaptic density. Predicted to be active in several cellular components, including hippocampal mossy fiber to CA3 synapse; parallel fiber to Purkinje cell synapse; and postsynaptic density, intracellular component. Predicted to be extrinsic component of postsynaptic membrane and extrinsic component of presynaptic membrane. Human ortholog(s) of this gene implicated in complex cortical dysplasia with other brain malformations. Orthologous to human CTNNA2 (catenin alpha 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 205.3) and Testes (RPKM 103.8) See more
Orthologs: human mouse all
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Genomic context

Location:: 4q33

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (110852265..112001351, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (109294249..110443409, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (107880611..109042724, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AU049796 (e-PCR)
- UniSTS:146242

D10Got117 (e-PCR)
- UniSTS:115797

AU026689 (e-PCR)
- UniSTS:114034

RH132643 (e-PCR)
- UniSTS:215926

d4mit28 (e-PCR)
- UniSTS:120445

Ctnna2 (e-PCR), detects polymorphism
- UniSTS:498318

RH130885 (e-PCR)
- UniSTS:214169

d4rat97 (e-PCR)
- UniSTS:122050

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	ISO Inferred from Sequence Orthology more info
enables beta-catenin binding	IBA Inferred from Biological aspect of Ancestor more info
enables cadherin binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables structural molecule activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in axonogenesis	ISO Inferred from Sequence Orthology more info
involved_in brain morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in dendrite morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in modification of postsynaptic actin cytoskeleton	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of Arp2/3 complex-mediated actin nucleation	ISO Inferred from Sequence Orthology more info
involved_in prepulse inhibition	ISO Inferred from Sequence Orthology more info
involved_in radial glia guided migration of Purkinje cell	ISO Inferred from Sequence Orthology more info
involved_in regulation of neuron migration	ISO Inferred from Sequence Orthology more info
involved_in regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in regulation of synapse structural plasticity	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in actin cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in adherens junction	IBA Inferred from Biological aspect of Ancestor more info
located_in adherens junction	ISO Inferred from Sequence Orthology more info
located_in axon	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
part_of catenin complex	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in extrinsic component of postsynaptic membrane	ISO Inferred from Sequence Orthology more info
is_active_in extrinsic component of presynaptic membrane	ISO Inferred from Sequence Orthology more info
is_active_in hippocampal mossy fiber to CA3 synapse	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in parallel fiber to Purkinje cell synapse	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density, intracellular component	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic active zone cytoplasmic component	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: catenin alpha-2

Names: catenin (cadherin associated protein), alpha 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.