U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Cpa2 carboxypeptidase A2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 296959, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
Cpa2provided by RGD
Official Full Name
carboxypeptidase A2provided by RGD
Primary source
RGD:1305563
See related
EnsemblRapid:ENSRNOG00000010463 AllianceGenome:RGD:1305563
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
CPA2(S)
Summary
Predicted to enable metallocarboxypeptidase activity and zinc ion binding activity. Predicted to be involved in proteolysis. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to human CPA2 (carboxypeptidase A2). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Spleen (RPKM 4786.0) and Liver (RPKM 1290.3) See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Cpa2 in Genome Data Viewer
Location:
4q22
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (60125297..60151066)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (59160357..59183677)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (57855416..57879239)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 209 Neighboring gene serine-rich single-pass membrane protein 1 Neighboring gene uncharacterized LOC120102251 Neighboring gene carboxypeptidase A4 Neighboring gene uncharacterized LOC102553416 Neighboring gene carboxypeptidase A5

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Carboxypeptidase A isoforms produced by distinct genes or alternative splicing in brain and other extrapancreatic tissues. Normant E, et al. J Biol Chem, 1995 Sep 1. PMID 7657630
  2. A novel rat carboxypeptidase, CPA2: characterization, molecular cloning, and evolutionary implications on substrate specificity in the carboxypeptidase gene family. Gardell SJ, et al. J Biol Chem, 1988 Nov 25. PMID 3182871
  3. Structural evolution of an enzyme specificity. The structure of rat carboxypeptidase A2 at 1.9-A resolution. Faming Z, et al. J Biol Chem, 1991 Dec 25. PMID 1761558
  4. Carboxypeptidases A1 and A2 from the perfusate of rat mesenteric arterial bed differentially process angiotensin peptides. Pereira HJ, et al. Peptides, 2012 Jan. PMID 22178042
  5. Procarboxypeptidase in rat pancreas. Overall characterization and comparison of the activation processes. Oppezzo O, et al. Eur J Biochem, 1994 May 15. PMID 8200353

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables carboxypeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables metallocarboxypeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metallocarboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metallocarboxypeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables metallocarboxypeptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
carboxypeptidase A2
Names
carboxypeptidase A2 (pancreatic)
NP_001013101.2
XP_038963208.1
XP_063141810.1
XP_063141811.1
XP_063141812.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013083.2 → NP_001013101.2  carboxypeptidase A2 precursor

    See identical proteins and their annotated locations for NP_001013101.2

    Status: VALIDATED

    Source sequence(s)
    CF249031, CF249075, CF249156, CF249511
    UniProtKB/Swiss-Prot
    P19222, Q6LD54
    UniProtKB/TrEMBL
    A6IEG7, G3V976
    Related
    ENSRNOP00000038495.3, ENSRNOT00000029608.4
    Conserved Domains (2) summary
    cd03870
    Location:116 → 415
    M14_CPA; Peptidase M14 carboxypeptidase subfamily A/B-like; Carboxypeptidase A subgroup
    pfam02244
    Location:33 → 100
    Propep_M14; Carboxypeptidase activation peptide

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    60125297..60151066
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063285740.1 → XP_063141810.1  carboxypeptidase A2 isoform X1

    UniProtKB/Swiss-Prot
    P19222, Q6LD54
    UniProtKB/TrEMBL
    A6IEG7, G3V976

  2. XM_063285741.1 → XP_063141811.1  carboxypeptidase A2 isoform X1

    UniProtKB/Swiss-Prot
    P19222, Q6LD54
    UniProtKB/TrEMBL
    A6IEG7, G3V976

  3. XM_063285742.1 → XP_063141812.1  carboxypeptidase A2 isoform X2

    UniProtKB/TrEMBL
    A6IEG8

  4. XM_039107280.2 → XP_038963208.1  carboxypeptidase A2 isoform X3

    UniProtKB/TrEMBL
    A6IEG8
    Conserved Domains (1) summary
    cd03870
    Location:1 → 285
    M14_CPA; Peptidase M14 carboxypeptidase subfamily A/B-like; Carboxypeptidase A subgroup
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P19222.1 GenPept UniProtKB/Swiss-Prot:P19222

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools