Klrc1 killer cell lectin like receptor C1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Klrc1provided by RGD
Official Full Name: killer cell lectin like receptor C1provided by RGD
Primary source: RGD:2976
See related: EnsemblRapid:ENSRNOG00000055196 AllianceGenome:RGD:2976
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: rNKG2A
Summary: Predicted to enable HLA-E specific inhibitory MHC class Ib receptor activity and MHC class I protein complex binding activity. Predicted to be involved in CD8-positive, gamma-delta intraepithelial T cell differentiation; immune response-regulating cell surface receptor signaling pathway; and regulation of leukocyte mediated cytotoxicity. Predicted to be located in plasma membrane. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Orthologous to several human genes including KLRC1 (killer cell lectin like receptor C1). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Spleen (RPKM 66.0), Lung (RPKM 35.9) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4q42

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (164828163..164838446, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (163142142..163152425, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (163453435..163463718, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables HLA-E specific inhibitory MHC class Ib receptor activity	ISO Inferred from Sequence Orthology more info
enables MHC class I protein complex binding	ISO Inferred from Sequence Orthology more info
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables inhibitory MHC class Ib receptor activity	ISO Inferred from Sequence Orthology more info
NOT enables protein antigen binding	ISO Inferred from Sequence Orthology more info
enables transmembrane signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in CD8-positive, gamma-delta intraepithelial T cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
involved_in natural killer cell inhibitory signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of natural killer cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of natural killer cell mediated cytotoxicity	IBA Inferred from Biological aspect of Ancestor more info
involved_in stimulatory C-type lectin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: killer cell lectin-like receptor subfamily C, member 1

Names: natural killer cell protein group 2-A (NKG2A)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001037441.2 → NP_001032518.1 killer cell lectin-like receptor subfamily C, member 1

See identical proteins and their annotated locations for NP_001032518.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004

UniProtKB/TrEMBL

A6IM76, O54872

Related

ENSRNOP00000069271.2, ENSRNOT00000085671.3

Conserved Domains (1) summary

cd03593
Location:120 → 232

CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)