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Psma4 proteasome 20S subunit alpha 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29671, updated on 27-Nov-2024

Summary

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Official Symbol
Psma4provided by RGD
Official Full Name
proteasome 20S subunit alpha 4provided by RGD
Primary source
RGD:61846
See related
EnsemblRapid:ENSRNOG00000013493 AllianceGenome:RGD:61846
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in P-body and nucleoplasm. Predicted to be part of proteasome core complex, alpha-subunit complex. Predicted to be active in cytosol and nucleus. Orthologous to human PSMA4 (proteasome 20S subunit alpha 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 746.9), Adrenal (RPKM 705.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Psma4 in Genome Data Viewer
Location:
8q24
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (64236520..64243980)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (55340431..55347893)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (59532456..59539916)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene iron responsive element binding protein 2 Neighboring gene hydroxylysine kinase Neighboring gene cholinergic receptor nicotinic alpha 5 subunit Neighboring gene zinc finger CCCH-type containing 15, pseudogene 2 Neighboring gene uncharacterized LOC120094166 Neighboring gene cholinergic receptor nicotinic alpha 3 subunit

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. cDNA cloning and sequencing of component C9 of proteasomes from rat hepatoma cells. Kumatori A, et al. FEBS Lett, 1990 May 21. PMID 2358075
  2. Molecular cloning of cDNAs for two subunits of rat multicatalytic proteinase. Existence of N-terminal conserved and C-terminal diverged sequences among subunits. Sorimachi H, et al. Eur J Biochem, 1990 Nov 13. PMID 2249692
  3. Parkin interacts with the proteasome subunit alpha4. Dächsel JC, et al. FEBS Lett, 2005 Jul 18. PMID 15987638
  4. PAC1-PAC2 proteasome assembly chaperone retains the core α4-α7 assembly intermediates in the cytoplasm. Wu W, et al. Genes Cells, 2018 Oct. PMID 30133132
  5. A mutually inhibitory feedback loop between the 20S proteasome and its regulator, NQO1. Moscovitz O, et al. Mol Cell, 2012 Jul 13. PMID 22793692

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Parkin interacts with the proteasome subunit alpha4
    Title: Parkin interacts with the proteasome subunit alpha4.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in P-body ISO
Inferred from Sequence Orthology
more info
  
located_in P-body ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of proteasome complex ISO
Inferred from Sequence Orthology
more info
  
part_of proteasome core complex ISO
Inferred from Sequence Orthology
more info
  
part_of proteasome core complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of proteasome core complex, alpha-subunit complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of proteasome core complex, alpha-subunit complex ISO
Inferred from Sequence Orthology
more info
  
part_of proteasome core complex, alpha-subunit complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
proteasome subunit alpha type-4
Names
alpha-3
macropain subunit C9
multicatalytic endopeptidase complex subunit C9
multicatalytic proteinase subunit L
proteasome (prosome, macropain) subunit, alpha type 4
proteasome alpha 4 subunit
proteasome component C9
proteasome subunit L
proteasome subunit alpha 4
proteasome subunit alpha-3
NP_058977.1
XP_038936898.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017281.1 → NP_058977.1  proteasome subunit alpha type-4

    See identical proteins and their annotated locations for NP_058977.1

    Status: PROVISIONAL

    Source sequence(s)
    X53304
    UniProtKB/Swiss-Prot
    P21670
    UniProtKB/TrEMBL
    A6J4N4, Q6P505
    Conserved Domains (1) summary
    cd03752
    Location:3 → 216
    proteasome_alpha_type_4; The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on top of one another forming ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    64236520..64243980
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039080970.2 → XP_038936898.1  proteasome subunit alpha type-4 isoform X1

    UniProtKB/Swiss-Prot
    P21670
    UniProtKB/TrEMBL
    A6J4N4, Q6P505
    Related
    ENSRNOP00000018173.5, ENSRNOT00000018173.8
    Conserved Domains (1) summary
    cd03752
    Location:3 → 216
    proteasome_alpha_type_4; The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on top of one another forming ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P21670.1 GenPept UniProtKB/Swiss-Prot:P21670

Gene LinkOut

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