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C8g complement C8 gamma chain [ Rattus norvegicus (Norway rat) ]

Gene ID: 296545, updated on 4-Jan-2025

Summary

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Official Symbol
C8gprovided by RGD
Official Full Name
complement C8 gamma chainprovided by RGD
Primary source
RGD:1309074
See related
AllianceGenome:RGD:1309074
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables complement binding activity. Predicted to be involved in complement activation. Located in extracellular space. Orthologous to human C8G (complement C8 gamma chain). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Liver (RPKM 922.2) and Kidney (RPKM 46.9) See more
Orthologs
human mouse all
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Genomic context

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See C8g in Genome Data Viewer
Location:
3p13
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (28718648..28720232, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (8320503..8322087, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (2724616..2727616, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA48 Neighboring gene lipocalin 12 Neighboring gene F-box and WD repeat domain containing 5 Neighboring gene Tnf receptor-associated factor 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Biosynthesis of C8 by hepatocytes. Differential expression and intracellular association of the alpha-gamma- and beta-subunits. Ng SC, et al. J Immunol, 1987 Nov 1. PMID 3312411
  2. Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability. Bastos-Amador P, et al. J Proteomics, 2012 Jun 27. PMID 22516433
  3. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article
  4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables complement binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in complement activation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
part_of membrane attack complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
complement component C8 gamma chain
Names
complement component 8, gamma polypeptide
complement component 8, gamma subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001399303.1 → NP_001386232.1  complement component C8 gamma chain isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A0A8I5ZP72, A6JT75

  2. NM_001399304.1 → NP_001386233.1  complement component C8 gamma chain isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    28718648..28720232 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001106555.1: Suppressed sequence

    Description
    NM_001106555.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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