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Tpd52l2 TPD52 like 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 296480, updated on 27-Nov-2024

Summary

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Official Symbol
Tpd52l2provided by RGD
Official Full Name
TPD52 like 2provided by RGD
Primary source
RGD:735167
See related
EnsemblRapid:ENSRNOG00000080504 AllianceGenome:RGD:735167
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable protein homodimerization activity. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in cytoplasm. Orthologous to human TPD52L2 (TPD52 like 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 161.8), Muscle (RPKM 155.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tpd52l2 in Genome Data Viewer
Location:
3q43
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (188972321..188995721)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (168598449..168618201)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (176989333..177009425)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene zinc finger and BTB domain containing 46 Neighboring gene RNA, U6 small nuclear 663 Neighboring gene uncharacterized LOC120101834 Neighboring gene uncharacterized LOC102548047 Neighboring gene abhydrolase domain containing 16B Neighboring gene ribosomal protein L34-like2 Neighboring gene DnaJ heat shock protein family (Hsp40) member C5 Neighboring gene uridine-cytidine kinase 1-like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. D53 (TPD52L1) is a cell cycle-regulated protein maximally expressed at the G2-M transition in breast cancer cells. Boutros R, et al. Exp Cell Res, 2005 Oct 15. PMID 16112108
  2. Cytokine-induced down-regulation of zfm1/splicing factor-1 promotes smooth muscle cell proliferation. Cattaruzza M, et al. J Biol Chem, 2002 Feb 22. PMID 11748220
  3. Identification of homo- and heteromeric interactions between members of the breast carcinoma-associated D52 protein family using the yeast two-hybrid system. Byrne JA, et al. Oncogene, 1998 Feb 19. PMID 9484778
  4. Phosphorylation and degradation of tomosyn-2 de-represses insulin secretion. Bhatnagar S, et al. J Biol Chem, 2014 Sep 5. PMID 25002582, Free PMC Article
  5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC73020

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
tumor protein D54
Names
tumor protein D52-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001431560.1 → NP_001418489.1  tumor protein D54 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A6KM05

  2. NM_001431561.1 → NP_001418490.1  tumor protein D54 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

  3. NM_001431562.1 → NP_001418491.1  tumor protein D54 isoform 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

  4. NM_001431563.1 → NP_001418492.1  tumor protein D54 isoform 5

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A6KM07

  5. NM_001431564.1 → NP_001418493.1  tumor protein D54 isoform 6

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

  6. NM_001431565.1 → NP_001418494.1  tumor protein D54 isoform 7

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

  7. NM_001431566.1 → NP_001418495.1  tumor protein D54 isoform 8

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

  8. NM_001431567.1 → NP_001418496.1  tumor protein D54 isoform 9

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A6KM00

  9. NM_001431568.1 → NP_001418497.1  tumor protein D54 isoform 10

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

  10. NM_198744.3 → NP_942039.1  tumor protein D54 isoform 2

    See identical proteins and their annotated locations for NP_942039.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/Swiss-Prot
    Q6PCT3
    UniProtKB/TrEMBL
    A6KM06, A6KM08
    Conserved Domains (1) summary
    pfam04201
    Location:55 → 211
    TPD52; tumor protein D52 family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    188972321..188995721
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006235761.4 → XP_006235823.1  tumor protein D54 isoform X13

    See identical proteins and their annotated locations for XP_006235823.1

    UniProtKB/TrEMBL
    A6KM02, A6KM08
    Conserved Domains (1) summary
    pfam04201
    Location:55 → 177
    TPD52; tumor protein D52 family

  2. XM_006235759.5 → XP_006235821.1  tumor protein D54 isoform X7

    Related
    ENSRNOP00000108826.1, ENSRNOT00000141925.1
    Conserved Domains (1) summary
    pfam04201
    Location:55 → 197
    TPD52; tumor protein D52 family

  3. XM_039104697.2 → XP_038960625.1  tumor protein D54 isoform X1

    Related
    ENSRNOP00000080130.2, ENSRNOT00000114740.2
    Conserved Domains (1) summary
    pfam04201
    Location:55 → 221
    TPD52; tumor protein D52 family

  4. XM_006235754.5 → XP_006235816.1  tumor protein D54 isoform X2

    Conserved Domains (1) summary
    pfam04201
    Location:55 → 220
    TPD52; tumor protein D52 family

  5. XM_039104698.2 → XP_038960626.1  tumor protein D54 isoform X3

  6. XM_063283451.1 → XP_063139521.1  tumor protein D54 isoform X18

  7. XM_063283448.1 → XP_063139518.1  tumor protein D54 isoform X14

  8. XM_063283449.1 → XP_063139519.1  tumor protein D54 isoform X16

  9. XM_017591623.3 → XP_017447112.1  tumor protein D54 isoform X19

  10. XM_039104700.2 → XP_038960628.1  tumor protein D54 isoform X6

    UniProtKB/TrEMBL
    A6KM08
    Conserved Domains (1) summary
    pfam04201
    Location:32 → 198
    TPD52; tumor protein D52 family

  11. XM_063283446.1 → XP_063139516.1  tumor protein D54 isoform X8

    UniProtKB/TrEMBL
    A6KM01

  12. XM_063283447.1 → XP_063139517.1  tumor protein D54 isoform X11

  13. XM_039104699.2 → XP_038960627.1  tumor protein D54 isoform X4

    Conserved Domains (1) summary
    pfam04201
    Location:55 → 201
    TPD52; tumor protein D52 family

  14. XM_039104702.2 → XP_038960630.1  tumor protein D54 isoform X12

    Conserved Domains (1) summary
    pfam04201
    Location:32 → 188
    TPD52; tumor protein D52 family

  15. XM_006235757.5 → XP_006235819.1  tumor protein D54 isoform X5

    See identical proteins and their annotated locations for XP_006235819.1

    UniProtKB/TrEMBL
    A6KM04
    Conserved Domains (1) summary
    pfam04201
    Location:55 → 200
    TPD52; tumor protein D52 family

  16. XM_039104701.2 → XP_038960629.1  tumor protein D54 isoform X9

    Conserved Domains (1) summary
    pfam04201
    Location:55 → 192
    TPD52; tumor protein D52 family

  17. XM_008762500.3 → XP_008760722.1  tumor protein D54 isoform X17

    UniProtKB/TrEMBL
    A6KM08
    Conserved Domains (1) summary
    pfam04201
    Location:32 → 154
    TPD52; Tumour protein D52 family

  18. XM_006235760.5 → XP_006235822.1  tumor protein D54 isoform X10

    See identical proteins and their annotated locations for XP_006235822.1

    UniProtKB/TrEMBL
    A6KM03, A6KM08
    Conserved Domains (1) summary
    pfam04201
    Location:55 → 191
    TPD52; tumor protein D52 family

  19. XM_039104703.2 → XP_038960631.1  tumor protein D54 isoform X15

    Conserved Domains (1) summary
    pfam04201
    Location:32 → 174
    TPD52; tumor protein D52 family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PCT3.1 GenPept UniProtKB/Swiss-Prot:Q6PCT3

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