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Mtg2 mitochondrial ribosome-associated GTPase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 296462, updated on 9-Dec-2024

Summary

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Official Symbol
Mtg2provided by RGD
Official Full Name
mitochondrial ribosome-associated GTPase 2provided by RGD
Primary source
RGD:1359243
See related
EnsemblRapid:ENSRNOG00000059919 AllianceGenome:RGD:1359243
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Gtpbp5
Summary
Predicted to enable GTPase activity. Predicted to be involved in regulation of mitochondrial translation and regulation of respiratory system process. Predicted to be located in mitochondrial inner membrane and mitochondrial ribosome. Orthologous to human MTG2 (mitochondrial ribosome associated GTPase 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Thymus (RPKM 83.1), Muscle (RPKM 66.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mtg2 in Genome Data Viewer
Location:
3q43
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (187543166..187558973)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (167165542..167181358)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (175448214..175464109)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene proteasome 20S subunit alpha 7 Neighboring gene SS18L1 subunit of BAF chromatin remodeling complex Neighboring gene histamine receptor H3 Neighboring gene oxysterol binding protein-like 2 Neighboring gene uncharacterized LOC120101831

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Human G-proteins, ObgH1 and Mtg1, associate with the large mitochondrial ribosome subunit and are involved in translation and assembly of respiratory complexes. Kotani T, et al. Nucleic Acids Res, 2013 Apr 1. PMID 23396448, Free PMC Article
  2. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
  3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of mitochondrial translation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of respiratory system process ISO
Inferred from Sequence Orthology
more info
  
involved_in ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial ribosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
mitochondrial ribosome-associated GTPase 2
Names
GTP-binding protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013924.2 → NP_001013946.2  mitochondrial ribosome-associated GTPase 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A0A8I6AA18, A6KMC2, Q5XIH5
    Related
    ENSRNOP00000088561.1, ENSRNOT00000119776.2

  2. NM_001430335.1 → NP_001417264.1  mitochondrial ribosome-associated GTPase 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A0A8I6AA18, A6KMC2, Q5XIH5

  3. NM_001430336.1 → NP_001417265.1  mitochondrial ribosome-associated GTPase 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    Q5XIH5

  4. NM_001430337.1 → NP_001417266.1  mitochondrial ribosome-associated GTPase 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

  5. NM_001430338.1 → NP_001417267.1  mitochondrial ribosome-associated GTPase 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A0A8I6AA18, A6KMC2, Q5XIH5

  6. NM_001430339.1 → NP_001417268.1  mitochondrial ribosome-associated GTPase 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    Q5XIH5

  7. NM_001430340.1 → NP_001417269.1  mitochondrial ribosome-associated GTPase 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

  8. NM_001430341.1 → NP_001417270.1  mitochondrial ribosome-associated GTPase 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A0A8I6AA18, A6KMC2, Q5XIH5

  9. NM_001430342.1 → NP_001417271.1  mitochondrial ribosome-associated GTPase 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A0A8I6AA18, A6KMC2, Q5XIH5

  10. NM_001430343.1 → NP_001417272.1  mitochondrial ribosome-associated GTPase 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

  11. NM_001430345.1 → NP_001417274.1  mitochondrial ribosome-associated GTPase 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A0A8I6AA18, A6KMC2, Q5XIH5

  12. NM_001430346.1 → NP_001417275.1  mitochondrial ribosome-associated GTPase 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

  13. NM_001430347.1 → NP_001417276.1  mitochondrial ribosome-associated GTPase 2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

  14. NM_001430348.1 → NP_001417277.1  mitochondrial ribosome-associated GTPase 2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    Q5XIH5

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    187543166..187558973
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063283429.1 → XP_063139499.1  mitochondrial ribosome-associated GTPase 2 isoform X1

    UniProtKB/TrEMBL
    Q5XIH5

  2. XM_063283424.1 → XP_063139494.1  mitochondrial ribosome-associated GTPase 2 isoform X1

    UniProtKB/TrEMBL
    Q5XIH5

  3. XM_063283437.1 → XP_063139507.1  mitochondrial ribosome-associated GTPase 2 isoform X5

  4. XM_006235818.5 → XP_006235880.1  mitochondrial ribosome-associated GTPase 2 isoform X1

    Related
    ENSRNOP00000110209.1, ENSRNOT00000172091.1
    Conserved Domains (1) summary
    TIGR02729
    Location:131 → 403
    Obg_CgtA; Obg family GTPase CgtA

  5. XM_063283436.1 → XP_063139506.1  mitochondrial ribosome-associated GTPase 2 isoform X5

  6. XM_063283435.1 → XP_063139505.1  mitochondrial ribosome-associated GTPase 2 isoform X5

  7. XM_063283426.1 → XP_063139496.1  mitochondrial ribosome-associated GTPase 2 isoform X1

    UniProtKB/TrEMBL
    Q5XIH5

  8. XM_063283434.1 → XP_063139504.1  mitochondrial ribosome-associated GTPase 2 isoform X3

  9. XM_063283425.1 → XP_063139495.1  mitochondrial ribosome-associated GTPase 2 isoform X1

  10. XM_063283430.1 → XP_063139500.1  mitochondrial ribosome-associated GTPase 2 isoform X2

    Related
    ENSRNOP00000073234.1, ENSRNOT00000089716.3

  11. XM_063283438.1 → XP_063139508.1  mitochondrial ribosome-associated GTPase 2 isoform X6

  12. XM_063283432.1 → XP_063139502.1  mitochondrial ribosome-associated GTPase 2 isoform X2

    UniProtKB/TrEMBL
    Q5XIH5

  13. XM_006235820.5 → XP_006235882.1  mitochondrial ribosome-associated GTPase 2 isoform X3

    Conserved Domains (1) summary
    TIGR02729
    Location:113 → 385
    Obg_CgtA; Obg family GTPase CgtA

  14. XM_063283427.1 → XP_063139497.1  mitochondrial ribosome-associated GTPase 2 isoform X1

    UniProtKB/TrEMBL
    Q5XIH5

  15. XM_063283439.1 → XP_063139509.1  mitochondrial ribosome-associated GTPase 2 isoform X7

  16. XM_017591618.3 → XP_017447107.1  mitochondrial ribosome-associated GTPase 2 isoform X4

    UniProtKB/TrEMBL
    Q5XIH5

  17. XM_063283431.1 → XP_063139501.1  mitochondrial ribosome-associated GTPase 2 isoform X2

    UniProtKB/TrEMBL
    Q5XIH5

  18. XM_063283433.1 → XP_063139503.1  mitochondrial ribosome-associated GTPase 2 isoform X3

    UniProtKB/TrEMBL
    A0A8I6AA18, A6KMC2, Q5XIH5

  19. XM_063283428.1 → XP_063139498.1  mitochondrial ribosome-associated GTPase 2 isoform X1

    UniProtKB/TrEMBL
    Q5XIH5
Nucleotide Protein Strain
Heading Accession and Version

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