Ptprj protein tyrosine phosphatase, receptor type, J [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ptprjprovided by RGD
Official Full Name: protein tyrosine phosphatase, receptor type, Jprovided by RGD
Primary source: RGD:3454
See related: EnsemblRapid:ENSRNOG00000034025 AllianceGenome:RGD:3454
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: DEP-1
Summary: Predicted to enable several functions, including beta-catenin binding activity; delta-catenin binding activity; and gamma-catenin binding activity. Predicted to be involved in several processes, including hemopoiesis; regulation of protein phosphorylation; and regulation of signal transduction. Predicted to act upstream of or within heart development; oligodendrocyte differentiation; and vasculogenesis. Predicted to be located in several cellular components, including cell surface; immunological synapse; and ruffle membrane. Used to study hypertension. Human ortholog(s) of this gene implicated in colorectal cancer; lung adenocarcinoma; lung squamous cell carcinoma; and thrombocytopenia. Orthologous to human PTPRJ (protein tyrosine phosphatase receptor type J). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Spleen (RPKM 340.0), Kidney (RPKM 290.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q24

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (96861785..97017702, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (76405917..76561842, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (79233519..79390956, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

rat tyrosine phosphatase eta increases cell adhesion by activating c-Src through dephosphorylation of its inhibitory phosphotyrosine residue
Title: The rat tyrosine phosphatase eta increases cell adhesion by activating c-Src through dephosphorylation of its inhibitory phosphotyrosine residue.
propose that the expression and activation of DEP-1/PTPeta is required for somatostatin inhibition of glioma proliferation
Title: The expression of the phosphotyrosine phosphatase DEP-1/PTPeta dictates the responsivity of glioma cells to somatostatin inhibition of cell proliferation.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AU046820 (e-PCR)
- UniSTS:111104

AI407676 (e-PCR)
- UniSTS:250121

D3Rat226 (e-PCR), detects polymorphism
- UniSTS:227612

PMC151692P1 (e-PCR)
- UniSTS:271164

RH135437 (e-PCR)
- UniSTS:218714

D3Wox33 (e-PCR)
- UniSTS:240530

BE101606 (e-PCR)
- UniSTS:243656

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables beta-catenin binding	ISO Inferred from Sequence Orthology more info
enables cadherin binding	ISO Inferred from Sequence Orthology more info
enables delta-catenin binding	ISO Inferred from Sequence Orthology more info
enables gamma-catenin binding	ISO Inferred from Sequence Orthology more info
enables histone H2AXY142 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables mitogen-activated protein kinase binding	ISO Inferred from Sequence Orthology more info
enables non-membrane spanning protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphatase activity	ISO Inferred from Sequence Orthology more info
enables platelet-derived growth factor receptor binding	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine phosphatase activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine phosphatase activity, metal-dependent	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in B cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in blood coagulation	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in glucose homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heart development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of MAP kinase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of epidermal growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of insulin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of platelet-derived growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of signaling receptor activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of vascular permeability	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within oligodendrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-tyrosine dephosphorylation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity	ISO Inferred from Sequence Orthology more info
involved_in platelet formation	ISO Inferred from Sequence Orthology more info
involved_in platelet-derived growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Fc receptor mediated stimulatory signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of calcium-mediated signaling	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of calcium-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of focal adhesion assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of macrophage chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phagocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of platelet activation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within vasculogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in immunological synapse	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in ruffle membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: receptor-type tyrosine-protein phosphatase eta

Names: density enhanced phosphatase-1

NP_001386049.1

EC 3.1.3.48

NP_058965.3

EC 3.1.3.48

XP_038960584.1

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001399120.1 → NP_001386049.1 receptor-type tyrosine-protein phosphatase eta isoform 2 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003
NM_017269.4 → NP_058965.3 receptor-type tyrosine-protein phosphatase eta isoform 1 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

Related

ENSRNOP00000044688.6, ENSRNOT00000049832.7

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

96861785..97017702 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039104656.2 → XP_038960584.1 receptor-type tyrosine-protein phosphatase eta isoform X1

UniProtKB/TrEMBL

A0A0G2JXZ9, A0A8I6GK94, A6HN64

Related

ENSRNOP00000070464.3, ENSRNOT00000077943.3

Conserved Domains (5) summary

smart00060
Location:557 → 631

FN3; Fibronectin type 3 domain

cd00063
Location:470 → 554

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14615
Location:1084 → 1312

R-PTPc-J; catalytic domain of receptor-type tyrosine-protein phosphatase J

pfam00041
Location:642 → 719

fn3; Fibronectin type III domain

pfam18861
Location:850 → 1015

PTP_tm; Transmembrane domain of protein tyrosine phosphatase, receptor type J