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Ralgds ral guanine nucleotide dissociation stimulator [ Rattus norvegicus (Norway rat) ]

Gene ID: 29622, updated on 27-Nov-2024

Summary

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Symbol
Ralgdsprovided by RGD
Full Name
ral guanine nucleotide dissociation stimulatorprovided by RGD
Primary source
RGD:3533
See related
EnsemblRapid:ENSRNOG00000010219 AllianceGenome:RGD:3533
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Rgds
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in Ras protein signal transduction. Predicted to be located in brush border; cytosol; and nucleus. Predicted to be active in plasma membrane. Orthologous to human RALGDS (ral guanine nucleotide dissociation stimulator). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 57.0), Spleen (RPKM 45.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ralgds in Genome Data Viewer
Location:
3p12
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (32237644..32278045)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (11839686..11880059)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (7090134..7130548)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene piercer of microtubule wall 1 Neighboring gene mitochondrial ribosomal protein S2 Neighboring gene globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 (FORS blood group) Neighboring gene carboxyl ester lipase Neighboring gene general transcription factor IIIC subunit 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Ral GDP dissociation stimulator and Ral GTPase are involved in myocardial hypertrophy. Kawai M, et al. Hypertension, 2003 Apr. PMID 12642511
  2. Three-dimensional structure of the Ras-interacting domain of RalGDS. Huang L, et al. Nat Struct Biol, 1997 Aug. PMID 9253406
  3. Characterization of a guanine nucleotide dissociation stimulator for a ras-related GTPase. Albright CF, et al. EMBO J, 1993 Jan. PMID 8094051, Free PMC Article
  4. Activated Ras interacts with the Ral guanine nucleotide dissociation stimulator. Hofer F, et al. Proc Natl Acad Sci U S A, 1994 Nov 8. PMID 7972015, Free PMC Article
  5. Rap2A links intestinal cell polarity to brush border formation. Gloerich M, et al. Nat Cell Biol, 2012 Aug. PMID 22797597

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ral GDP dissociation stimulator is involved in myocardial hypertrophy.
    Title: Ral GDP dissociation stimulator and Ral GTPase are involved in myocardial hypertrophy.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTPase regulator activity ISO
Inferred from Sequence Orthology
more info
  
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
enables guanyl-nucleotide exchange factor activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in small GTPase-mediated signal transduction TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in brush border ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ral guanine nucleotide dissociation stimulator
Names
ral guanine nucleotide exchange factor
ralGEF

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001416483.1 → NP_001403412.1  ral guanine nucleotide dissociation stimulator isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    F1LN84

  2. NM_019250.2 → NP_062123.2  ral guanine nucleotide dissociation stimulator isoform 1

    Status: VALIDATED

    Source sequence(s)
    CB775259, CO561927, JAXUCZ010000003, L07925
    UniProtKB/Swiss-Prot
    Q03386
    Related
    ENSRNOP00000013809.8, ENSRNOT00000013809.9
    Conserved Domains (4) summary
    cd00153
    Location:779 → 864
    RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins
    smart00229
    Location:112 → 236
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00155
    Location:363 → 625
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    pfam11679
    Location:193 → 332
    DUF3275; Protein of unknown function (DUF3275)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    32237644..32278045
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006233752.3 → XP_006233814.1  ral guanine nucleotide dissociation stimulator isoform X3

    UniProtKB/TrEMBL
    A0A0G2K7U4, A0A8I6A8C4
    Related
    ENSRNOP00000087735.1, ENSRNOT00000096803.2
    Conserved Domains (4) summary
    cd00153
    Location:736 → 821
    RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins
    smart00229
    Location:57 → 193
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00155
    Location:320 → 582
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    pfam11679
    Location:150 → 289
    DUF3275; Protein of unknown function (DUF3275)

  2. XM_006233753.3 → XP_006233815.1  ral guanine nucleotide dissociation stimulator isoform X5

    UniProtKB/TrEMBL
    A0A0G2K7U4
    Related
    ENSRNOP00000074350.3, ENSRNOT00000084092.3
    Conserved Domains (4) summary
    cd00153
    Location:724 → 809
    RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins
    smart00229
    Location:57 → 181
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00155
    Location:308 → 570
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    pfam11679
    Location:138 → 277
    DUF3275; Protein of unknown function (DUF3275)

  3. XM_006233751.5 → XP_006233813.1  ral guanine nucleotide dissociation stimulator isoform X1

    UniProtKB/TrEMBL
    A0A0G2K7U4
    Conserved Domains (4) summary
    cd00153
    Location:779 → 864
    RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins
    smart00229
    Location:100 → 236
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00155
    Location:363 → 625
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    pfam11679
    Location:193 → 332
    DUF3275; Protein of unknown function (DUF3275)

  4. XM_063283357.1 → XP_063139427.1  ral guanine nucleotide dissociation stimulator isoform X6

  5. XM_063283354.1 → XP_063139424.1  ral guanine nucleotide dissociation stimulator isoform X2

    Related
    ENSRNOP00000111335.1, ENSRNOT00000164313.1

  6. XM_017591589.3 → XP_017447078.1  ral guanine nucleotide dissociation stimulator isoform X4

    UniProtKB/TrEMBL
    A0A0G2K7U4
    Related
    ENSRNOP00000100430.1, ENSRNOT00000142346.1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q03386.1 GenPept UniProtKB/Swiss-Prot:Q03386

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