Ubox5 U-box domain containing 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ubox5provided by RGD
Official Full Name: U-box domain containing 5provided by RGD
Primary source: RGD:1305440
See related: EnsemblRapid:ENSRNOG00000021230 AllianceGenome:RGD:1305440
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1305440
Summary: Predicted to enable ubiquitin protein ligase binding activity and ubiquitin-ubiquitin ligase activity. Predicted to be involved in protein polyubiquitination. Predicted to be located in focal adhesion and nuclear body. Predicted to be active in nucleus. Orthologous to human UBOX5 (U-box domain containing 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Heart (RPKM 45.6), Thymus (RPKM 38.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q36

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (138259311..138300807, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (117806212..117847711, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (123130249..123171875, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

BF403969 (e-PCR)
- UniSTS:246538

RH143755 (e-PCR)
- UniSTS:233001

RH127430 (e-PCR)
- UniSTS:210740

AA944524 (e-PCR)
- UniSTS:250245

AW531771 (e-PCR)
- UniSTS:260508

MARC_7301-7302:996687747:1 (e-PCR)
- UniSTS:269764

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin-ubiquitin ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin-ubiquitin ligase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in protein polyubiquitination	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein polyubiquitination	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in focal adhesion	IEA Inferred from Electronic Annotation more info
located_in focal adhesion	ISO Inferred from Sequence Orthology more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: RING finger protein 37

NP_001029169.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033997.1 → NP_001029169.1 RING finger protein 37

See identical proteins and their annotated locations for NP_001029169.1

Status: PROVISIONAL

Source sequence(s)

BC101912

UniProtKB/TrEMBL

A0A8I5ZXT6, Q3T1H9

Related

ENSRNOP00000028834.5, ENSRNOT00000028834.6

Conserved Domains (2) summary

cd16537
Location:479 → 525

RING-HC_RNF37; RING finger, HC subclass, found in RING finger protein 37 (RNF37)

cd16660
Location:260 → 312

RING-Ubox_RNF37; U-box domain, a modified RING finger, found in RING finger protein 37 (RNF37)