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Iftap intraflagellar transport associated protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 295952, updated on 4-Jan-2025

Summary

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Official Symbol
Iftapprovided by RGD
Official Full Name
intraflagellar transport associated proteinprovided by RGD
Primary source
RGD:1309730
See related
EnsemblRapid:ENSRNOG00000037567 AllianceGenome:RGD:1309730
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1309730
Summary
Predicted to enable intraciliary transport particle A binding activity. Predicted to be involved in acrosome reaction and spermatogenesis. Predicted to act upstream of or within fertilization. Predicted to be active in 9+0 non-motile cilium and cytosol. Orthologous to human IFTAP (intraflagellar transport associated protein). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Heart (RPKM 126.3), Muscle (RPKM 118.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Iftap in Genome Data Viewer
Location:
3q31
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (108242105..108361607, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (87812068..87906517, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (91086186..91195981, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486296 Neighboring gene uncharacterized LOC103691849 Neighboring gene recombination activating 2 Neighboring gene recombination activating 1 Neighboring gene TNF receptor associated factor 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Lack of NWC protein (c11orf74 homolog) in murine spermatogenesis results in reduced sperm competitiveness and impaired ability to fertilize egg cells in vitro. Majkowski M, et al. PLoS One, 2018. PMID 30521625, Free PMC Article
  2. Search for the Function of NWC, Third Gene Within RAG Locus: Generation and Characterization of NWC-Deficient Mice. Kasztura M, et al. Arch Immunol Ther Exp (Warsz), 2016 Aug. PMID 26703212, Free PMC Article
  3. C11ORF74 interacts with the IFT-A complex and participates in ciliary BBSome localization. Takahara M, et al. J Biochem, 2019 Mar 1. PMID 30476139
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables intraciliary transport particle A binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables intraciliary transport particle A binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in acrosome reaction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within acrosome reaction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within fertilization ISO
Inferred from Sequence Orthology
more info
  
involved_in spermatogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within spermatogenesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in 9+0 non-motile cilium IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in 9+0 non-motile cilium ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
intraflagellar transport-associated protein
Names
uncharacterized protein C11orf74 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106491.3 → NP_001099961.3  intraflagellar transport-associated protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A6HNM0, B2RYT8
    Related
    ENSRNOP00000107731.1, ENSRNOT00000160521.1

  2. NM_001429176.1 → NP_001416105.1  intraflagellar transport-associated protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A6HNM0, B2RYT8

  3. NM_001429177.1 → NP_001416106.1  intraflagellar transport-associated protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    B2RYT8

  4. NM_001429178.1 → NP_001416107.1  intraflagellar transport-associated protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

  5. NM_001429179.1 → NP_001416108.1  intraflagellar transport-associated protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    108242105..108361607 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063283301.1 → XP_063139371.1  intraflagellar transport-associated protein isoform X3

    UniProtKB/TrEMBL
    F1LQ29

  2. XM_063283300.1 → XP_063139370.1  intraflagellar transport-associated protein isoform X2

  3. XM_063283304.1 → XP_063139374.1  intraflagellar transport-associated protein isoform X6

  4. XM_063283305.1 → XP_063139375.1  intraflagellar transport-associated protein isoform X7

    UniProtKB/TrEMBL
    A6HNM1

  5. XM_063283299.1 → XP_063139369.1  intraflagellar transport-associated protein isoform X1

    UniProtKB/TrEMBL
    B2RYT8
    Related
    ENSRNOP00000099641.1, ENSRNOT00000140635.1

  6. XM_063283302.1 → XP_063139372.1  intraflagellar transport-associated protein isoform X4

    UniProtKB/TrEMBL
    F1LQ29

  7. XM_063283303.1 → XP_063139373.1  intraflagellar transport-associated protein isoform X5

    UniProtKB/TrEMBL
    F1LQ29
Nucleotide Protein Strain
Heading Accession and Version

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