Htr2a 5-hydroxytryptamine receptor 2A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Htr2aprovided by RGD
Official Full Name: 5-hydroxytryptamine receptor 2Aprovided by RGD
Primary source: RGD:61800
See related: EnsemblRapid:ENSRNOG00000010063 AllianceGenome:RGD:61800
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: 5Ht-2; 5-HT2A
Summary: Predicted to enable several functions, including 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding activity; serotonin binding activity; and transmembrane signaling receptor activity. Involved in several processes, including detection of stimulus involved in sensory perception of pain; learning or memory; and positive regulation of MAPK cascade. Located in several cellular components, including cell body fiber; dendritic shaft; and neurofilament. Is active in glutamatergic synapse; postsynaptic membrane; and presynaptic membrane. Used to study several diseases, including alcohol dependence; alcohol use disorder; cocaine abuse; cocaine dependence; and nicotine dependence. Biomarker of several diseases, including alcohol dependence; alcohol use disorder; bladder neck obstruction; cocaine abuse; and congenital diaphragmatic hernia. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; alcoholic psychosis; cocaine dependence; nicotine dependence; and obsessive-compulsive disorder. Orthologous to human HTR2A (5-hydroxytryptamine receptor 2A). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Brain (RPKM 49.5), Heart (RPKM 14.5) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15q11

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (56360647..56428703)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (49950035..50022188)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (56666152..56732469)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The serotonin(5-HT)2A receptor is involved in the hypersensitivity of bladder afferent neurons in cyclophosphamide-induced cystitis.
Title: The serotonin(5-HT)2A receptor is involved in the hypersensitivity of bladder afferent neurons in cyclophosphamide-induced cystitis.
5-HT1A and 5-HT2A receptor effects on recognition memory, motor/exploratory behaviors, emotionality and regional dopamine transporter binding in the rat.
Title: 5-HT(1A) and 5-HT(2A) receptor effects on recognition memory, motor/exploratory behaviors, emotionality and regional dopamine transporter binding in the rat.
Intranasal delivery of shRNA to knockdown the 5HT-2A receptor enhances memory and alleviates anxiety.
Title: Intranasal delivery of shRNA to knockdown the 5HT-2A receptor enhances memory and alleviates anxiety.
The 5-HT2A, 5-HT5A, and 5-HT6 serotonergic receptors in the medial prefrontal cortex behave differently in extinction learning: Does social support play a role?
Title: The 5-HT2A, 5-HT5A, and 5-HT6 serotonergic receptors in the medial prefrontal cortex behave differently in extinction learning: Does social support play a role?
Reduced Expression of the Htr2a, Grin1, and Bdnf Genes and Cognitive Inflexibility in a Model of High Compulsive Rats.
Title: Reduced Expression of the Htr2a, Grin1, and Bdnf Genes and Cognitive Inflexibility in a Model of High Compulsive Rats.
5-HT2A/B receptor expression in the phrenic motor nucleus in a rat model of ALS (SOD1(G93A)).
Title: 5-HT2A/B receptor expression in the phrenic motor nucleus in a rat model of ALS (SOD1(G93A)).
HTR2A promotes the development of cardiac hypertrophy by activating PI3K-PDK1-AKT-mTOR signaling.
Title: HTR2A promotes the development of cardiac hypertrophy by activating PI3K-PDK1-AKT-mTOR signaling.
Unusual Quadrupedal Locomotion in Rat during Recovery from Lumbar Spinal Blockade of 5-HT7 Receptors.
Title: Unusual Quadrupedal Locomotion in Rat during Recovery from Lumbar Spinal Blockade of 5-HT(7) Receptors.
Contribution of 5-HT2 Receptors to the Control of the Spinal Locomotor System in Intact Rats.
Title: Contribution of 5-HT(2) Receptors to the Control of the Spinal Locomotor System in Intact Rats.
Serotonin 5-HT2A and 5-HT2C receptors regulate rat maternal behavior through distinct behavioral and neural mechanisms.
Title: Serotonin 5-HT(2A) and 5-HT(2C) receptors regulate rat maternal behavior through distinct behavioral and neural mechanisms.

Submit: New GeneRIF Correction See all GeneRIFs (151)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Htr2a (e-PCR), detects polymorphism
- UniSTS:143421

Htr2a (e-PCR), detects polymorphism
- UniSTS:143422

HTR2A-2 (e-PCR)
- UniSTS:31941

HTR2A-112F (e-PCR)
- UniSTS:31941

G45129 (e-PCR)
- UniSTS:105931

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding	ISO Inferred from Sequence Orthology more info
enables G protein-coupled serotonin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled serotonin receptor activity	ISO Inferred from Sequence Orthology more info
enables Gq/11-coupled serotonin receptor activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables neurotransmitter receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein tyrosine kinase activator activity	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables serotonin binding	ISO Inferred from Sequence Orthology more info
enables serotonin receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled serotonin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in artery smooth muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in behavioral response to cocaine	IDA Inferred from Direct Assay more info	PubMed
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in detection of mechanical stimulus involved in sensory perception of pain	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in detection of temperature stimulus involved in sensory perception of pain	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of glycolytic process	ISO Inferred from Sequence Orthology more info
involved_in intracellular calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of potassium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of synaptic transmission, glutamatergic	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in phospholipase C-activating serotonin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipase C-activating serotonin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in phospholipase C-activating serotonin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAP kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytokine production involved in immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of execution phase of apoptosis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of fat cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of glycolytic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of heat generation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of platelet aggregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of vasoconstriction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in presynaptic modulation of chemical synaptic transmission	EXP Inferred from Experiment more info	PubMed
involved_in presynaptic modulation of chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein localization to cytoskeleton	ISO Inferred from Sequence Orthology more info
involved_in regulation of dopamine secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in release of sequestered calcium ion into cytosol	IBA Inferred from Biological aspect of Ancestor more info
involved_in release of sequestered calcium ion into cytosol	ISO Inferred from Sequence Orthology more info
involved_in response to cocaine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to xenobiotic stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
involved_in sensitization	IEP Inferred from Expression Pattern more info	PubMed
involved_in sensitization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory perception of temperature stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in serotonin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in temperature homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in urinary bladder smooth muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of G protein-coupled serotonin receptor complex	ISO Inferred from Sequence Orthology more info
located_in axon	IEA Inferred from Electronic Annotation more info
located_in caveola	IEA Inferred from Electronic Annotation more info
located_in cell body fiber	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendritic shaft	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in neurofilament	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: 5-hydroxytryptamine receptor 2A

Names: 5-HT-2; 5-HT-2A; 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled; serotonin 5HT-2 receptor; serotonin receptor 2A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017254.1 → NP_058950.1 5-hydroxytryptamine receptor 2A

See identical proteins and their annotated locations for NP_058950.1

Status: PROVISIONAL

Source sequence(s)

M30705

UniProtKB/Swiss-Prot

P14842

UniProtKB/TrEMBL

A6HTR4

Related

ENSRNOP00000013408.4, ENSRNOT00000013408.8

Conserved Domains (1) summary

cd15304
Location:75 → 391

7tmA_5-HT2A; serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors