Pcolce procollagen C-endopeptidase enhancer [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pcolceprovided by RGD
Official Full Name: procollagen C-endopeptidase enhancerprovided by RGD
Primary source: RGD:3270
See related: EnsemblRapid:ENSRNOG00000025001 AllianceGenome:RGD:3270
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: PCPE
Summary: Predicted to enable collagen binding activity; heparin binding activity; and peptidase activator activity. Predicted to be involved in proteolysis. Predicted to act upstream of or within cellular response to leukemia inhibitory factor. Predicted to be located in extracellular region. Orthologous to human PCOLCE (procollagen C-endopeptidase enhancer). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Adrenal (RPKM 761.6), Muscle (RPKM 411.4) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12q12

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (24720972..24727287)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (19084191..19090508)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (22153995..22160311)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results establish aldosterone as a physiological stimulator of PCPE-1 expression in the remodeling myocardium after infarction.
Title: Expression of procollagen C-proteinase enhancer-1 in the remodeling rat heart is stimulated by aldosterone.
role in stabilization of RNA in noncollagenous protein synthesis as well as collagen synthesis in hepatic stellate cells
Title: Stabilization of RNA strands in protein synthesis by type I procollagen C-proteinase enhancer protein, a potential RNA-binding protein, in hepatic stellate cells.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables collagen binding	IBA Inferred from Biological aspect of Ancestor more info
enables collagen binding	IEA Inferred from Electronic Annotation more info
enables collagen binding	ISO Inferred from Sequence Orthology more info
enables heparin binding	IEA Inferred from Electronic Annotation more info
enables heparin binding	ISO Inferred from Sequence Orthology more info
enables peptidase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptidase activator activity	IEA Inferred from Electronic Annotation more info
enables peptidase activator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to leukemia inhibitory factor	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within proteolysis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: procollagen C-endopeptidase enhancer 1

Names: PCPE-1; procollagen C-endopeptidase enhancer protein; procollagen C-proteinase enhancer 1; procollagen C-proteinase enhancer protein; procollagen COOH-terminal proteinase enhancer 1; type 1 procollagen C-proteinase enhancer protein; type I procollagen COOH-terminal proteinase enhancer

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019237.1 → NP_062110.1 procollagen C-endopeptidase enhancer 1 precursor

Status: PROVISIONAL

Source sequence(s)

U94710

UniProtKB/Swiss-Prot

O08628

UniProtKB/TrEMBL

A6J011, Q5RJN2

Related

ENSRNOP00000073700.1, ENSRNOT00000080775.3

Conserved Domains (2) summary

cd00041
Location:36 → 146

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd03576
Location:334 → 460

NTR_PCOLCE; NTR domain, PCOLCE subfamily; Procollagen C-endopeptidase enhancers (PCOLCEs) are extracellular matrix proteins that enhance the activity of procollagen C-proteases, by binding to the procollagen I C-peptide. They contain a C-terminal NTR domain, which ...