Pigk phosphatidylinositol glycan anchor biosynthesis, class K [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pigkprovided by RGD
Official Full Name: phosphatidylinositol glycan anchor biosynthesis, class Kprovided by RGD
Primary source: RGD:1306753
See related: EnsemblRapid:ENSRNOG00000042359 AllianceGenome:RGD:1306753
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable GPI-anchor transamidase activity. Predicted to be involved in attachment of GPI anchor to protein. Predicted to be part of GPI-anchor transamidase complex. Orthologous to human PIGK (phosphatidylinositol glycan anchor biosynthesis class K). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 173.8), Liver (RPKM 164.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q45

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (244289928..244375394)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (241630021..241715493)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (257911099..257997735)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GPI-anchor transamidase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in GPI anchor biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of GPI-anchor transamidase complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: GPI-anchor transamidase

Names: phosphatidylinositol glycan, class K

NP_001011953.1

EC 3.-.-.-

XP_008759771.1

EC 3.-.-.-

XP_038958046.1

EC 3.-.-.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001011953.1 → NP_001011953.1 GPI-anchor transamidase precursor

See identical proteins and their annotated locations for NP_001011953.1

Status: PROVISIONAL

Source sequence(s)

BC083636

UniProtKB/TrEMBL

A0A8I5Y6Z7, A0A8I6AH05, A6HWM4, F1M7W4, Q5XIP2

Related

ENSRNOP00000076726.1, ENSRNOT00000102861.2

Conserved Domains (1) summary

cl00042
Location:42 → 332

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

244289928..244375394

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039102118.2 → XP_038958046.1 GPI-anchor transamidase isoform X2

UniProtKB/TrEMBL

A6HWM5

Conserved Domains (1) summary

cl00042
Location:42 → 217

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
XM_008761549.3 → XP_008759771.1 GPI-anchor transamidase isoform X1

UniProtKB/TrEMBL

A0A8J8YK78

Related

ENSRNOP00000104768.1, ENSRNOT00000123981.1

Conserved Domains (1) summary

cl00042
Location:42 → 332

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...