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Homer3 homer scaffold protein 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29548, updated on 2-Nov-2024

Summary

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Official Symbol
Homer3provided by RGD
Official Full Name
homer scaffold protein 3provided by RGD
Primary source
RGD:620706
See related
EnsemblRapid:ENSRNOG00000020229 AllianceGenome:RGD:620706
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Vesl-3
Summary
Predicted to enable G protein-coupled glutamate receptor binding activity; identical protein binding activity; and protein domain specific binding activity. Predicted to be involved in several processes, including G protein-coupled glutamate receptor signaling pathway; negative regulation of interleukin-2 production; and regulation of signal transduction. Predicted to be located in basal part of cell and cytosol. Predicted to be active in several cellular components, including dendrite; glutamatergic synapse; and postsynaptic density. Orthologous to human HOMER3 (homer scaffold protein 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 88.9), Adrenal (RPKM 88.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Homer3 in Genome Data Viewer
Location:
16p14
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (19166141..19176701, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (19132177..19142739, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (20880447..20890968, complement)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene UPF1, RNA helicase and ATPase Neighboring gene ceramide synthase 1 Neighboring gene growth differentiation factor 1 Neighboring gene COPI coat complex subunit epsilon Neighboring gene DEAD-box helicase 49 Neighboring gene SURP and G patch domain containing 2 Neighboring gene transmembrane protein 60-like Neighboring gene U6 spliceosomal RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Homer proteins regulate coupling of group I metabotropic glutamate receptors to N-type calcium and M-type potassium channels. Kammermeier PJ, et al. J Neurosci, 2000 Oct 1. PMID 11007880, Free PMC Article
  2. The expression of plasticity-related genes in an acute model of stress is modulated by chronic desipramine in a time-dependent manner within medial prefrontal cortex. Nava N, et al. Eur Neuropsychopharmacol, 2017 Jan. PMID 27890541
  3. Homer is concentrated at the postsynaptic density and does not redistribute after acute synaptic stimulation. Tao-Cheng JH, et al. Neuroscience, 2014 Apr 25. PMID 24530450, Free PMC Article
  4. Phosphorylation of Homer3 by calcium/calmodulin-dependent kinase II regulates a coupling state of its target molecules in Purkinje cells. Mizutani A, et al. J Neurosci, 2008 May 14. PMID 18480293, Free PMC Article
  5. Homer 2 tunes G protein-coupled receptors stimulus intensity by regulating RGS proteins and PLCbeta GAP activities. Shin DM, et al. J Cell Biol, 2003 Jul 21. PMID 12860966, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The acute foodshake-stress induced reduction of Homer3 mRNA levels compared to sham animals at the same time point that was prevented by chronic treatment with desipramine.
    Title: The expression of plasticity-related genes in an acute model of stress is modulated by chronic desipramine in a time-dependent manner within medial prefrontal cortex.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G protein-coupled glutamate receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled glutamate receptor binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled glutamate receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in G protein-coupled glutamate receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of calcineurin-NFAT signaling cascade IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of calcineurin-NFAT signaling cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of calcineurin-NFAT signaling cascade ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of interleukin-2 production IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of interleukin-2 production ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of interleukin-2 production ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of postsynaptic neurotransmitter receptor activity ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of store-operated calcium entry IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in basal part of cell ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in postsynaptic density IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in postsynaptic density IEA
Inferred from Electronic Annotation
more info
  
is_active_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
  
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
homer protein homolog 3
Names
VASP/Ena-related gene up-regulated during seizure and LTP 3
homer homolog 3
homer scaffolding protein 3
homer, neuronal immediate early gene, 3
homer-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053310.1 → NP_445762.1  homer protein homolog 3

    See identical proteins and their annotated locations for NP_445762.1

    Status: PROVISIONAL

    Source sequence(s)
    AB020879
    UniProtKB/Swiss-Prot
    Q9Z2X5
    UniProtKB/TrEMBL
    A6KA67
    Conserved Domains (1) summary
    cd01206
    Location:6 → 114
    EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    19166141..19176701 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006252890.5 → XP_006252952.1  homer protein homolog 3 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AJC0
    Related
    ENSRNOP00000093275.1, ENSRNOT00000108210.2
    Conserved Domains (1) summary
    cd01206
    Location:6 → 114
    EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain

  2. XM_039094433.2 → XP_038950361.1  homer protein homolog 3 isoform X7

    UniProtKB/TrEMBL
    A0A8L2QEN4
    Related
    ENSRNOP00000027428.5, ENSRNOT00000027428.7
    Conserved Domains (2) summary
    cd01206
    Location:6 → 114
    EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain
    TIGR02168
    Location:95 → 312
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  3. XM_006252891.5 → XP_006252953.1  homer protein homolog 3 isoform X4

    See identical proteins and their annotated locations for XP_006252953.1

    UniProtKB/Swiss-Prot
    Q9Z2X5
    UniProtKB/TrEMBL
    A6KA67
    Conserved Domains (1) summary
    cd01206
    Location:6 → 114
    EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain

  4. XM_039094432.2 → XP_038950360.1  homer protein homolog 3 isoform X6

    Conserved Domains (2) summary
    COG1196
    Location:150 → 322
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd01206
    Location:6 → 114
    EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain

  5. XM_008771095.4 → XP_008769317.1  homer protein homolog 3 isoform X3

    Conserved Domains (1) summary
    cd01206
    Location:6 → 114
    EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain

  6. XM_039094431.2 → XP_038950359.1  homer protein homolog 3 isoform X5

    Conserved Domains (2) summary
    COG1196
    Location:150 → 328
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd01206
    Location:6 → 114
    EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain

  7. XM_008771094.4 → XP_008769316.1  homer protein homolog 3 isoform X2

    UniProtKB/TrEMBL
    A0A8I6AH27
    Related
    ENSRNOP00000091926.1, ENSRNOT00000098457.2
    Conserved Domains (1) summary
    cd01206
    Location:6 → 114
    EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain

  8. XM_063275272.1 → XP_063131342.1  homer protein homolog 3 isoform X4

    UniProtKB/Swiss-Prot
    Q9Z2X5
    UniProtKB/TrEMBL
    A6KA67
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z2X5.2 GenPept UniProtKB/Swiss-Prot:Q9Z2X5

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