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Mettl14 methyltransferase 14, N6-adenosine-methyltransferase non-catalytic subunit [ Rattus norvegicus (Norway rat) ]

Gene ID: 295428, updated on 4-Jan-2025

Summary

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Official Symbol
Mettl14provided by RGD
Official Full Name
methyltransferase 14, N6-adenosine-methyltransferase non-catalytic subunitprovided by RGD
Primary source
RGD:1304822
See related
EnsemblRapid:ENSRNOG00000015250 AllianceGenome:RGD:1304822
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1304822
Summary
Predicted to enable mRNA binding activity and mRNA m(6)A methyltransferase activity. Involved in response to nutrient levels. Predicted to be located in nucleoplasm. Predicted to be part of RNA N6-methyladenosine methyltransferase complex. Predicted to be active in nucleus. Biomarker of traumatic brain injury. Orthologous to human METTL14 (methyltransferase 14, N6-adenosine-methyltransferase non-catalytic subunit). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Thymus (RPKM 95.7), Kidney (RPKM 87.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mettl14 in Genome Data Viewer
Location:
2q42
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (214215165..214231412, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (211530598..211546845, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (227566811..227583047, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene synaptopodin 2 Neighboring gene uncharacterized LOC134485960 Neighboring gene SEC24 homolog D, COPII coat complex component Neighboring gene RNA, U6atac small nuclear Neighboring gene elongin B, pseduogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. METTL14 regulates microglia/macrophage polarization and NLRP3 inflammasome activation after ischemic stroke by the KAT3B-STING axis. Li Y, et al. Neurobiol Dis, 2023 Sep. PMID 37541353
  2. METTL14 promotes fibroblast-like synoviocytes activation via the LASP1/SRC/AKT axis in rheumatoid arthritis. Li X, et al. Am J Physiol Cell Physiol, 2023 May 1. PMID 36878846
  3. Upregulation of UBR1 m6A Methylation by METTL14 Inhibits Autophagy in Spinal Cord Injury. Wang C, et al. eNeuro, 2023 Jun. PMID 37094938, Free PMC Article
  4. METTL14 suppresses pyroptosis and diabetic cardiomyopathy by downregulating TINCR lncRNA. Meng L, et al. Cell Death Dis, 2022 Jan 10. PMID 35013106, Free PMC Article
  5. [Osteogenic Capacity and Mettl14 and Notch1 Expression of Adipose-Derived Stem Cells from Osteoporotic Rats]. Feng MG, et al. Sichuan Da Xue Xue Bao Yi Xue Ban, 2021 May. PMID 34018360, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. METTL14 promotes chondrocyte ferroptosis in osteoarthritis via m6A modification of GPX4.
    Title: METTL14 promotes chondrocyte ferroptosis in osteoarthritis via m6A modification of GPX4.
  2. METTL14 regulates microglia/macrophage polarization and NLRP3 inflammasome activation after ischemic stroke by the KAT3B-STING axis.
    Title: METTL14 regulates microglia/macrophage polarization and NLRP3 inflammasome activation after ischemic stroke by the KAT3B-STING axis.
  3. Upregulation of UBR1 m6A Methylation by METTL14 Inhibits Autophagy in Spinal Cord Injury.
    Title: Upregulation of UBR1 m6A Methylation by METTL14 Inhibits Autophagy in Spinal Cord Injury.
  4. METTL14 promotes fibroblast-like synoviocytes activation via the LASP1/SRC/AKT axis in rheumatoid arthritis.
    Title: METTL14 promotes fibroblast-like synoviocytes activation via the LASP1/SRC/AKT axis in rheumatoid arthritis.
  5. METTL14 suppresses pyroptosis and diabetic cardiomyopathy by downregulating TINCR lncRNA.
    Title: METTL14 suppresses pyroptosis and diabetic cardiomyopathy by downregulating TINCR lncRNA.
  6. [Osteogenic Capacity and Mettl14 and Notch1 Expression of Adipose-Derived Stem Cells from Osteoporotic Rats].
    Title: [Osteogenic Capacity and Mettl14 and Notch1 Expression of Adipose-Derived Stem Cells from Osteoporotic Rats].
  7. N6-methyladenosine methyltransferase plays a role in hypoxic preconditioning partially through the interaction with lncRNA H19.
    Title: N6-methyladenosine methyltransferase plays a role in hypoxic preconditioning partially through the interaction with lncRNA H19.
  8. our results demonstrated the functional importance of METTL14-dependent vascular m6A methylome in vascular functions during calcification and provided a novel mechanistic insight to the therapeutic mechanisms of METTL14
    Title: METTL14-dependent m6A regulates vascular calcification induced by indoxyl sulfate.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
NOT enables S-adenosyl-L-methionine binding ISO
Inferred from Sequence Orthology
more info
  
enables mRNA binding ISO
Inferred from Sequence Orthology
more info
  
NOT enables mRNA m(6)A methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables mRNA m(6)A methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in RNA methylation ISO
Inferred from Sequence Orthology
more info
  
involved_in forebrain radial glial cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in gliogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA destabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA modification ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA processing ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA stabilization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of negative regulation of hematopoietic progenitor cell differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of positive regulation of translation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in response to nutrient levels IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in spermatogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in stem cell population maintenance ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of RNA N6-methyladenosine methyltransferase complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
N6-adenosine-methyltransferase non-catalytic subunit
Names
N6-adenosine-methyltransferase subunit METTL14
methyltransferase 14, N6-adenosine-methyltransferase subunit
methyltransferase like 14
methyltransferase-like protein 14
NP_001386178.1
XP_038958022.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001399249.1 → NP_001386178.1  N6-adenosine-methyltransferase non-catalytic subunit

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    A6HVI9, A6HVJ1, B2RYI4, D4A701, F7F7M4
    Related
    ENSRNOP00000020574.5, ENSRNOT00000020574.9
    Conserved Domains (1) summary
    pfam05063
    Location:186 → 363
    MT-A70

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    214215165..214231412 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039102094.2 → XP_038958022.1  N6-adenosine-methyltransferase non-catalytic subunit isoform X1

    Conserved Domains (1) summary
    pfam05063
    Location:19 → 196
    MT-A70

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001106470.1: Suppressed sequence

    Description
    NM_001106470.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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