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Igsf3 immunoglobulin superfamily, member 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 295325, updated on 4-Jan-2025

Summary

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Official Symbol
Igsf3provided by RGD
Official Full Name
immunoglobulin superfamily, member 3provided by RGD
Primary source
RGD:1307796
See related
EnsemblRapid:ENSRNOG00000023851 AllianceGenome:RGD:1307796
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in lacrimal gland development. Predicted to be active in membrane. Human ortholog(s) of this gene implicated in lacrimal duct obstruction. Orthologous to human IGSF3 (immunoglobulin superfamily member 3). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Heart (RPKM 47.9), Kidney (RPKM 32.1) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Igsf3 in Genome Data Viewer
Location:
2q34
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (191499972..191588249)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (188811394..188899645)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (203768364..203855573)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene Cd2 molecule Neighboring gene peptidylprolyl isomerase A, pseudogene 5 Neighboring gene uncharacterized LOC103691652 Neighboring gene ATPase Na+/K+ transporting subunit alpha 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification of an IGSF3 mutation in a family with congenital nasolacrimal duct obstruction. Foster J 2nd, et al. Clin Genet, 2014 Dec. PMID 24372406
  2. Quantitative proteomics identifies a Dab2/integrin module regulating cell migration. Teckchandani A, et al. J Cell Biol, 2009 Jul 13. PMID 19581412, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in lacrimal gland development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
immunoglobulin superfamily member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106455.2 → NP_001099925.1  immunoglobulin superfamily member 3 precursor

    See identical proteins and their annotated locations for NP_001099925.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    A6K3H6, F1LZ40
    Related
    ENSRNOP00000018894.6, ENSRNOT00000018895.8
    Conserved Domains (3) summary
    smart00410
    Location:561 → 684
    IG_like; Immunoglobulin like
    pfam07686
    Location:561 → 684
    V-set; Immunoglobulin V-set domain
    cl11960
    Location:29 → 120
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    191499972..191588249
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039102064.2 → XP_038957992.1  immunoglobulin superfamily member 3 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AJX2
    Related
    ENSRNOP00000093223.1, ENSRNOT00000112581.2
    Conserved Domains (4) summary
    pfam07686
    Location:707 → 804
    V-set; Immunoglobulin V-set domain
    cd00096
    Location:709 → 712
    Ig; Ig strand A' [structural motif]
    cd00099
    Location:152 → 251
    IgV; Immunoglobulin variable domain (IgV)
    cl11960
    Location:27 → 141
    Ig; Immunoglobulin domain

  2. XM_039102066.2 → XP_038957994.1  immunoglobulin superfamily member 3 isoform X2

    UniProtKB/TrEMBL
    A0A0G2K7L2
    Related
    ENSRNOP00000074253.1, ENSRNOT00000080176.3
    Conserved Domains (4) summary
    pfam07686
    Location:687 → 784
    V-set; Immunoglobulin V-set domain
    cd00096
    Location:689 → 692
    Ig; Ig strand A' [structural motif]
    cd00099
    Location:152 → 251
    IgV; Immunoglobulin variable domain (IgV)
    cl11960
    Location:27 → 141
    Ig; Immunoglobulin domain

  3. XM_063281633.1 → XP_063137703.1  immunoglobulin superfamily member 3 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AJX2
Nucleotide Protein Strain
Heading Accession and Version

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