Dnajb12 DnaJ heat shock protein family (Hsp40) member B12 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dnajb12provided by RGD
Official Full Name: DnaJ heat shock protein family (Hsp40) member B12provided by RGD
Primary source: RGD:1359677
See related: EnsemblRapid:ENSRNOG00000030408 AllianceGenome:RGD:1359677
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable Hsp70 protein binding activity. Predicted to be involved in several processes, including ERAD pathway; cellular response to misfolded protein; and chaperone cofactor-dependent protein refolding. Predicted to be located in endoplasmic reticulum and nuclear membrane. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human DNAJB12 (DnaJ heat shock protein family (Hsp40) member B12). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 167.8), Muscle (RPKM 147.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 20q11

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (28371180..28389390)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (27828216..27846428)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (29445510..29463739)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

UniSTS:236356 (e-PCR)
- UniSTS:236356

RH141822 (e-PCR)
- UniSTS:223814

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables Hsp70 protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables Hsp70 protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in ERAD pathway	ISO Inferred from Sequence Orthology more info
involved_in cellular response to misfolded protein	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to misfolded protein	ISO Inferred from Sequence Orthology more info
involved_in chaperone cofactor-dependent protein refolding	IBA Inferred from Biological aspect of Ancestor more info
involved_in chaperone cofactor-dependent protein refolding	ISO Inferred from Sequence Orthology more info
involved_in protein-containing complex assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: dnaJ homolog subfamily B member 12

Names: DnaJ (Hsp40) homolog, subfamily B, member 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001013907.3 → NP_001013929.1 dnaJ homolog subfamily B member 12

See identical proteins and their annotated locations for NP_001013929.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000020

UniProtKB/TrEMBL

Q5FVC4

Conserved Domains (2) summary

pfam00226
Location:111 → 172

DnaJ; DnaJ domain

pfam09320
Location:269 → 369

DUF1977; Domain of unknown function (DUF1977)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086038.1 Reference GRCr8

Range

28371180..28389390

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039098616.2 → XP_038954544.1 dnaJ homolog subfamily B member 12 isoform X1

UniProtKB/TrEMBL

A6K3V6, F7F4L4

Related

ENSRNOP00000049600.4, ENSRNOT00000044805.5

Conserved Domains (2) summary

TIGR02349
Location:111 → 237

DnaJ_bact; chaperone protein DnaJ

pfam09320
Location:269 → 369

DUF1977; Domain of unknown function (DUF1977)