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Hs3st5 heparan sulfate-glucosamine 3-sulfotransferase 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 294449, updated on 27-Nov-2024

Summary

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Official Symbol
Hs3st5provided by RGD
Official Full Name
heparan sulfate-glucosamine 3-sulfotransferase 5provided by RGD
Primary source
RGD:1306379
See related
EnsemblRapid:ENSRNOG00000000605 AllianceGenome:RGD:1306379
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity. Predicted to be involved in several processes, including heparan sulfate proteoglycan biosynthetic process, enzymatic modification; protein sulfation; and regulation of viral entry into host cell. Orthologous to human HS3ST5 (heparan sulfate-glucosamine 3-sulfotransferase 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 38.1), Brain (RPKM 23.9) and 4 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Hs3st5 in Genome Data Viewer
Location:
20q12
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (41661785..41972550)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (40106876..40417661)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (40236437..40545502)

Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S8, pseudogene 3 Neighboring gene peptidylprolyl isomerase D, pseudogene 15 Neighboring gene uncharacterized LOC134483815 Neighboring gene transfer RNA threonine (anticodon AGU) 35 Neighboring gene ribosomal protein L13A, pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Characterization of a heparan sulfate 3-O-sulfotransferase-5, an enzyme synthesizing a tetrasulfated disaccharide. Mochizuki H, et al. J Biol Chem, 2003 Jul 18. PMID 12740361
  2. Heparan sulfate 3-O-sulfotransferase isoform 5 generates both an antithrombin-binding site and an entry receptor for herpes simplex virus, type 1. Xia G, et al. J Biol Chem, 2002 Oct 4. PMID 12138164
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in heparan sulfate proteoglycan biosynthetic process, enzymatic modification ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of coagulation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein sulfation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of viral entry into host cell ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
heparan sulfate glucosamine 3-O-sulfotransferase 5
Names
heparan sulfate (glucosamine) 3-O-sulfotransferase 5
NP_001099862.1
XP_017457112.1
XP_017457114.1
XP_017457115.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106392.1 → NP_001099862.1  heparan sulfate glucosamine 3-O-sulfotransferase 5

    See identical proteins and their annotated locations for NP_001099862.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474051
    UniProtKB/TrEMBL
    A6KID5, D3ZDL1
    Conserved Domains (1) summary
    pfam00685
    Location:90 → 330
    Sulfotransfer_1; Sulfotransferase domain

  2. NM_001434620.1 → NP_001421549.1  heparan sulfate glucosamine 3-O-sulfotransferase 5

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000020

  3. NM_001434621.1 → NP_001421550.1  heparan sulfate glucosamine 3-O-sulfotransferase 5

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000020

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086038.1 Reference GRCr8

    Range
    41661785..41972550
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017601626.3 → XP_017457115.1  heparan sulfate glucosamine 3-O-sulfotransferase 5 isoform X1

    UniProtKB/TrEMBL
    A6KID5, D3ZDL1
    Conserved Domains (1) summary
    pfam00685
    Location:90 → 330
    Sulfotransfer_1; Sulfotransferase domain

  2. XM_017601623.3 → XP_017457112.1  heparan sulfate glucosamine 3-O-sulfotransferase 5 isoform X1

    UniProtKB/TrEMBL
    A6KID5, D3ZDL1
    Related
    ENSRNOP00000000743.2, ENSRNOT00000000743.5
    Conserved Domains (1) summary
    pfam00685
    Location:90 → 330
    Sulfotransfer_1; Sulfotransferase domain

  3. XM_017601625.3 → XP_017457114.1  heparan sulfate glucosamine 3-O-sulfotransferase 5 isoform X1

    UniProtKB/TrEMBL
    A6KID5, D3ZDL1
    Conserved Domains (1) summary
    pfam00685
    Location:90 → 330
    Sulfotransfer_1; Sulfotransferase domain
Nucleotide Protein Strain
Heading Accession and Version

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