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Pknox1 PBX/knotted 1 homeobox 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 294322, updated on 4-Jan-2025

Summary

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Official Symbol
Pknox1provided by RGD
Official Full Name
PBX/knotted 1 homeobox 1provided by RGD
Primary source
RGD:1305003
See related
EnsemblRapid:ENSRNOG00000001184 AllianceGenome:RGD:1305003
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Predicted to be involved in angiogenesis. Predicted to act upstream of or within camera-type eye development; hemopoiesis; and positive regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm and nucleus. Predicted to be part of transcription regulator complex. Orthologous to human PKNOX1 (PBX/knotted 1 homeobox 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Muscle (RPKM 73.5), Thymus (RPKM 71.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pknox1 in Genome Data Viewer
Location:
20p12
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (9664120..9706328)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (9662866..9705030)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (10331608..10358922)

Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene NADH:ubiquinone oxidoreductase subunit V3 Neighboring gene small nucleolar RNA SNORA36 family Neighboring gene cystathionine beta synthase Neighboring gene U2 small nuclear RNA auxiliary factor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Involvement of Prep1 in the alphabeta T-cell receptor T-lymphocytic potential of hematopoietic precursors. Penkov D, et al. Mol Cell Biol, 2005 Dec. PMID 16314502, Free PMC Article
  2. MiR-17 family-mediated regulation of Pknox1 influences hepatic steatosis and insulin signaling. Ye D, et al. J Cell Mol Med, 2018 Dec. PMID 30338914, Free PMC Article
  3. The homeodomain transcription factor Prep1 (pKnox1) is required for hematopoietic stem and progenitor cell activity. Di Rosa P, et al. Dev Biol, 2007 Nov 15. PMID 17904118
  4. In vivo analysis of developmentally and evolutionarily dynamic protein-DNA interactions regulating transcription of the Pgk2 gene during mammalian spermatogenesis. Yoshioka H, et al. Mol Cell Biol, 2007 Nov. PMID 17875925, Free PMC Article
  5. Activin regulation of the follicle-stimulating hormone beta-subunit gene involves Smads and the TALE homeodomain proteins Pbx1 and Prep1. Bailey JS, et al. Mol Endocrinol, 2004 May. PMID 14764653, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC109503

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within T cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within angiogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within camera-type eye development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within erythrocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within hemopoiesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of transcription regulator complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
homeobox protein PKNOX1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013074.3 → NP_001013092.1  homeobox protein PKNOX1 isoform 1

    See identical proteins and their annotated locations for NP_001013092.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000020
    UniProtKB/TrEMBL
    A0A8I6AIY1, A0A8I6G373, Q5BJP1
    Conserved Domains (2) summary
    pfam05920
    Location:277 → 316
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:80 → 165
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

  2. NM_001434615.1 → NP_001421544.1  homeobox protein PKNOX1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000020
    UniProtKB/TrEMBL
    A0A8I6AIY1

  3. NM_001434616.1 → NP_001421545.1  homeobox protein PKNOX1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000020
    UniProtKB/TrEMBL
    A0A8I6AIY1, A0A8I6G373, Q5BJP1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086038.1 Reference GRCr8

    Range
    9664120..9706328
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039098545.2 → XP_038954473.1  homeobox protein PKNOX1 isoform X1

    Related
    ENSRNOP00000001566.7, ENSRNOT00000001566.8
    Conserved Domains (2) summary
    pfam05920
    Location:277 → 316
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:80 → 165
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

  2. XM_063279041.1 → XP_063135111.1  homeobox protein PKNOX1 isoform X2

  3. XM_039098547.2 → XP_038954475.1  homeobox protein PKNOX1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AIY1, A0A8I6G373, Q5BJP1
    Conserved Domains (2) summary
    pfam05920
    Location:277 → 316
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:80 → 165
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

  4. XM_039098544.2 → XP_038954472.1  homeobox protein PKNOX1 isoform X1

    Conserved Domains (2) summary
    pfam05920
    Location:277 → 316
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:80 → 165
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

  5. XM_039098546.2 → XP_038954474.1  homeobox protein PKNOX1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AIY1, A0A8I6G373, Q5BJP1
    Related
    ENSRNOP00000079378.1, ENSRNOT00000107714.2
    Conserved Domains (2) summary
    pfam05920
    Location:277 → 316
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:80 → 165
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

  6. XM_039098548.2 → XP_038954476.1  homeobox protein PKNOX1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AIY1, A0A8I6G373, Q5BJP1
    Conserved Domains (2) summary
    pfam05920
    Location:277 → 316
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:80 → 165
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

  7. XM_039098549.2 → XP_038954477.1  homeobox protein PKNOX1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AIY1, A0A8I6G373, Q5BJP1
    Conserved Domains (2) summary
    pfam05920
    Location:277 → 316
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:80 → 165
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

  8. XM_008772808.4 → XP_008771030.1  homeobox protein PKNOX1 isoform X1

    See identical proteins and their annotated locations for XP_008771030.1

    UniProtKB/TrEMBL
    A0A8I6AIY1, A0A8I6G373, Q5BJP1
    Conserved Domains (2) summary
    pfam05920
    Location:277 → 316
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:80 → 165
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
Nucleotide Protein Strain
Heading Accession and Version

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