Ralgdsl2 ral guanine nucleotide dissociation stimulator like 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ralgdsl2provided by RGD
Official Full Name: ral guanine nucleotide dissociation stimulator like 2provided by RGD
Primary source: RGD:1302985
See related: EnsemblRapid:ENSRNOG00000000474 AllianceGenome:RGD:1302985
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Rgl2; Ke1.5; Rab2l
Summary: Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in small GTPase-mediated signal transduction. Predicted to act upstream of or within negative regulation of cardiac muscle cell apoptotic process; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; and regulation of Ral protein signal transduction. Orthologous to human RGL2 (ral guanine nucleotide dissociation stimulator like 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Lung (RPKM 101.5), Thymus (RPKM 83.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 20p12

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (4950379..4958315, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (4948495..4956774, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (5458509..5466853, complement)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH138742 (e-PCR)
- UniSTS:220829

RH140614 (e-PCR)
- UniSTS:222683

RH129413 (e-PCR)
- UniSTS:212720

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of cardiac muscle cell apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of Ral protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in small GTPase-mediated signal transduction	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ral guanine nucleotide dissociation stimulator-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_212547.3 → NP_997712.1 ral guanine nucleotide dissociation stimulator-like 2

See identical proteins and their annotated locations for NP_997712.1

Status: VALIDATED

Source sequence(s)

BC107439, DY316563

UniProtKB/TrEMBL

A0A0U1RS29, A6JJI3, F7EQI7, Q6MGC5

Conserved Domains (3) summary

cd00153
Location:649 → 734

RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins

smart00229
Location:90 → 212

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

cd00155
Location:239 → 509

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086038.1 Reference GRCr8

Range

4950379..4958315 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063279023.1 → XP_063135093.1 ral guanine nucleotide dissociation stimulator-like 2 isoform X1

Related

ENSRNOP00000000554.5, ENSRNOT00000000554.8
XM_063279024.1 → XP_063135094.1 ral guanine nucleotide dissociation stimulator-like 2 isoform X2
XM_063279025.1 → XP_063135095.1 ral guanine nucleotide dissociation stimulator-like 2 isoform X3